Galmik

Galmik
Klinički podaci
Identifikatori
ATC kod	?
PubChem	11636593
ChEMBL	CHEMBL578918
Hemijski podaci
Formula	C51H60N10O11
Mol. masa	989,080
SMILES	eMolekuli & PubHem
InChI
	InChI=1S/C51H60N10O11/c1-26-36-41(64)61-51(6,45(68)55-38-32-21-13-11-19-30(32)31-20-12-14-22-33(31)38)48-58-37(28(3)72-48)40(63)60-50(5,44(67)54-34(42(65)69-7)23-15-16-24-52)47-57-35(27(2)71-47)39(62)59-49(4,46(56-36)70-26)43(66)53-25-29-17-9-8-10-18-29/h11-14,19-22,29,34,38H,8-10,15-18,23-25,52H2,1-7H3,(H,53,66)(H,54,67)(H,55,68)(H,59,62)(H,60,63)(H,61,64)/t34-,49-,50-,51-/m0/s1 ; Key: DOHGPSDHRIKTDB-UHFFFAOYSA-N
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Galmik je lek koji deluje kao selektivni, ne-peptidni agonist galaninskih receptora.^[4] On je pokazao antiepileptičke, antidepresivne i analgetske efekte u životinjskim studijama,^[5] ali isto tako inhibira memorijske funkcije.^[6]

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
↑ Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). „Synthesis of galmic: a nonpeptide galanin receptor agonist”. Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16727–32. DOI:10.1073/pnas.0407543101. PMC 534730. PMID 15557002.
↑ Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). „Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests”. Proceedings of the National Academy of Sciences of the United States of America 101 (28): 10470–5. DOI:10.1073/pnas.0403802101. PMC 478593. PMID 15240875.
↑ Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). „Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice”. Neuropeptides 39 (3): 249–51. DOI:10.1016/j.npep.2004.12.010. PMID 15944018.

Vanjske veze

	Portal Medicina
	Portal Hemija

Šablon:Neuropeptidni ligandi

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid15557002-4] Ceide SC, Trembleau L, Haberhauer G, Somogyi L, Lu X, Bartfai T, Rebek J (November 2004). „Synthesis of galmic: a nonpeptide galanin receptor agonist”. Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16727–32. DOI:10.1073/pnas.0407543101. PMC 534730. PMID 15557002.

[pmid15240875-5] Bartfai T, Lu X, Badie-Mahdavi H, Barr AM, Mazarati A, Hua XY, Yaksh T, Haberhauer G, Ceide SC, Trembleau L, Somogyi L, Kröck L, Rebek J (July 2004). „Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests”. Proceedings of the National Academy of Sciences of the United States of America 101 (28): 10470–5. DOI:10.1073/pnas.0403802101. PMC 478593. PMID 15240875.

[pmid15944018-6] Badie-Mahdavi H, Behrens MM, Rebek J, Bartfai T (June 2005). „Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice”. Neuropeptides 39 (3): 249–51. DOI:10.1016/j.npep.2004.12.010. PMID 15944018.

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Literatura

Vanjske veze

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