Science Signaling
- Volume 15
- Issue 730
- 19 Apr 2022
ONLINE COVER This week, Coulis et al. report that oxidation of the protein tyrosine phosphatase PTP1B alters microRNA processing to promote thyroid hormone–induced cardiac hypertrophy. The image shows how cardiomyocyte-specific deficiency of PTP1B exacerbates cardiac hypertrophy triggered by pressure overload.
Credit: Coulis et al./Science SignalingResearch ArticlesBy
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Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment
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- et al.
Protein tyrosine phosphatase 1B regulates miR-208b-argonaute 2 association and thyroid hormone responsiveness in cardiac hypertrophy
FocusBy
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Science Signaling is a weekly, online journal for the life sciences. We publish studies that uncover basic mechanisms underlying biological processes in all organisms. We are particularly interested in studies that provide new insights into physiology, delineate mechanisms that cause disease, identify potential therapeutic targets and strategies, and characterize the effects of drugs.
mission & scopeEditors’ Choice
19 Apr 2022
Shining a light on rhodopsin signaling
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Brain aging by gut AGE
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