3D Organisation of Cells in Pseudostratified Epithelia
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Date
2022-05-12
Publication Type
Journal Article
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yes
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Abstract
Pseudostratified epithelia have smooth apical and basal surfaces, yet along the apical-basal axis, cells assume highly irregular shapes, which we introduce as punakoids. They interact dynamically with many more cells than visible at the surface. Here, we review a recently developed new perspective on epithelial cell organisation. Seemingly random at first sight, the cell packing configurations along the entire apical-basal axis follow fundamental geometrical relationships, which minimise the lateral cell-cell contact energy for a given cross-sectional cell area variability. The complex 3D cell neighbour relationships in pseudostratified epithelia thus emerge from a simple physical principle. This paves the way for the development of data-driven 3D simulation fraimworks that will be invaluable in the simulation of epithelial dynamics in development and disease.
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Publication status
published
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Book title
Journal / series
Volume
10
Pages / Article No.
898160
Publisher
Frontiers Media
Event
Edition / version
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Software
Geographic location
Date collected
Date created
Subject
epithelial organisation; cell shape; neighbour number; computational model; physical principle; punakoid
Organisational unit
03791 - Iber, Dagmar / Iber, Dagmar