Day 4 of our five day Fall TV Premiere includes the return of FOX's animation lineup, while the network goes big with a time travel-based, dinosaur-packed adventure. We've also got the return of Miami's busiest serial killer, one very cranky doctor, 1920s gangsters and much more. So check out what's premiering from September 25th though October 2nd!

Network: FOX
Airs: Sundays at 8:00pm ET/PT
Season Premiere:9/25/11
The Simpsons' landmark 23rd season will take the iconic animated series to episode 500 and beyond! So what can we expect from the big 5-0-0? "There's a big town meeting that the Simpsons don't know about," producer/showrunner Al Jean told us, "but when they go in they discover that the rest of the town is saying, 'We're going to get rid of The Simpsons! We're sick of them.'" And what guest voices will pop up this year? Well, Kiefer Sutherland, Andy Garcia, John Rivers, Jane Lynch, Jonah Hill, Tim & Eric, Neil Gaiman and Gordon Ramsay to name a few.

Check out what else Al Jean had to say about Season 23 when IGN toured the Simpsons' animation studio over the summer!

Network: FOX
Airs: Sundays at 9:00pm ET/PT
Season Premiere: 9/25/11
Having most recently landed on IGN's Top 25 Funniest TV Shows of All Time, Family Guy returns for Season 10 this year with episodes that will feature Peter becoming friends with Ryan Reynolds (as himself), the Griffins winning the lottery, Meg falling in love with an Amish boy, Stewie driving the family car, Meg dating Quagmire on her 18th birthday, Peter befriending a dolphin (voiced by Ricky Gervais) and Brian and Stewie traveling back in time to the very first episode of the series. Network: ABC
Airs: Sundays at 10:00pm ET/PT
Series Premiere: 9/25/11
Much like NBC and The Playboy Club, ABC is trying its own hand with a retro-60's show – possibly mistaking the gimmick for surefire acclaim. Both shows are definitely inspired by all the buzz that surrounds AMC's Mad Men, but since ABC can't afford to get the meager ratings that Mad Men actually gets, they have to go broader with this tale about a group of Pan Am stewardesses who slip-slide their way through global espionage, radical political movements and love amongst the "mile high club." Kelli Garner, Margot Robbie, Karine Vanasse and "Usually from Movies" Christina Ricci star in this Cold War-era primetime soap. Network: HBO
Airs: Sundays at 9:00pm ET/PT
Season Premiere: 9/25/11
HBO's bloody historical bootleg gangster drama returns to find Steve Buscemi's Nucky ducking attacks from just about everyone around him. After the events from last season, there's really no one left for Nucky to trust, but the question will be will he be able to see his enemies coming? As Dabney Coleman's Commodore and Michael Pitt's Jimmy plot for Nucky's downfall, will it be Kelly Macdonald's Margaret who Nucky turns to as an ally? Network: FOX
Airs: Mondays at 8:00pm ET/PT
Series Premiere: 9/26/11
This ambitious and much-hyped series finally sees its debut, after a couple of delays due to the scope, scale and effects that come tied to a show about a group of humans from the future who time travel to the prehistoric age, after their world becomes unlivable. Jason O'Mara plays the father of the family the show centers on, with Avatar's Stephen Lang portraying the leader of Terra Nova, the colony the humans live in. But watch out, because if you live in the prehistoric era, the weather might be nice, but those dinosaurs can be hell!

Network: The CW
Airs: Mondays at 9:00pm ET/PT
Series Premiere: 9/26/11
Josh Schwartz (Chuck, The OC) is one of the producers behind this series, which stars his former OC actress (and Chuck guest star) Rachel Bilson as a recent NYC med school graduate who reluctantly begins her career as a doctor in a small Southern town. Okay, this is not exactly an IGN-type series, but we love the ever-charming Bilson and she's joined by a likable cast that includes Scott Porter (Friday Night Lights) and Jaime King (Sin City).