Content-Length: 21350 | pFad | https://www.ncbi.nlm.nih.gov/pubmed/4682131?dopt=Abstract

000 Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone

Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone

Science. 1973 Jan 5;179(4068):77-9. doi: 10.1126/science.179.4068.77.

Abstract

A peptide has been isolated from ovine hypothalamus which, at 1 x 10(-9)M, inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH The synthetic replicate is biologically active.

MeSH terms

  • Amino Acid Sequence
  • Amino Acids / analysis
  • Animals
  • Antigens
  • Cerebellum / analysis
  • Growth Hormone / blood
  • Growth Hormone / metabolism*
  • Hypothalamus / analysis*
  • Peptides / administration & dosage
  • Peptides / analysis
  • Peptides / isolation & purification
  • Peptides / pharmacology*
  • Pituitary Gland / drug effects*
  • Pituitary Gland / physiology
  • Radioimmunoassay
  • Rats
  • Sheep
  • Tissue Extracts / administration & dosage
  • Tissue Extracts / analysis
  • Tissue Extracts / isolation & purification
  • Tissue Extracts / pharmacology*

Substances

  • Amino Acids
  • Antigens
  • Peptides
  • Tissue Extracts
  • Growth Hormone








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