إبيرجولين

EREG
بنى متوفرة
بنك بيانات البروتين	Ortholog search: PDBe RCSB
قائمة رموز معرفات بنك بيانات البروتين
	1K36, 1K37, 5E8D
معرفات
أسماء بديلة	EREG, EPR, ER, Ep, epiregulin
معرفات خارجية	الوراثة المندلية البشرية عبر الإنترنت 602061 MGI: MGI:107508 HomoloGene: 1097 GeneCards: 2069
علم الوجود الجيني
وظائف جزيئية	• epidermal growth factor receptor binding; • ‏GO:0001948، ‏GO:0016582 ربط بروتيني; • growth factor activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
مكونات خلوية	• مكون تكاملي للغشاء; • غشاء; • غشاء خلوي; • integral component of plasma membrane; • الفراغ خارج الخلية; • داخل خلوي; • خارج خلوي; • clathrin-coated vesicle membrane;
عمليات حيوية	• luteinizing hormone signaling pathway; • positive regulation of epidermal growth factor-activated receptor activity; • تمايز خلوي; • ovarian cumulus expansion; • negative regulation of smooth muscle cell differentiation; • ‏GO:0032737 positive regulation of cytokine production; • cytokine-mediated signaling pathway; • positive regulation of fibroblast proliferation; • cell-cell signaling; • anatomical structure morphogenesis; • response to peptide hormone; • التئام الجروح; • mRNA transcription; • female meiotic nuclear division; • primary follicle stage; • keratinocyte differentiation; • MAPK cascade; • نمو متعدد الخلايا; • positive regulation of DNA replication; • keratinocyte proliferation; • oocyte maturation; • توليد الأوعية; • ضبط زيادي للتكاثر الخلوي; • positive regulation of innate immune response; • negative regulation of epithelial cell proliferation; • تشكل العضو الحيواني; • positive regulation of phosphorylation; • ‏GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of mitotic nuclear division; • إباضة; • positive regulation of cell division; • negative regulation of cell population proliferation; • positive regulation of smooth muscle cell proliferation; • positive regulation of protein kinase activity; • ERBB2 signaling pathway; • regulation of cell motility; • epidermal growth factor receptor signaling pathway; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol phosphate biosynthetic process; • positive regulation of protein kinase B signaling; • ‏GO:0072468 توصيل الإشارة; • negative regulation of epidermal growth factor receptor signaling pathway; • membrane organization;
	المصادر:Amigo / QuickGO
تماثلات متسلسلة
	O14944
	Q61521
	NM_001432
	NM_007950
	NP_001423
	NP_031976
	ويكي بيانات
اعرض/عدّل إنسان	اعرض/عدّل فأر

إبيرجولين‏ (Epiregulin) هوَ بروتين يُشَفر بواسطة جين Epiregulin في الإنسان.^[1]^[2]

الوظيفة

الأهمية السريرية

المراجع

^ Toyoda H، Komurasaki T، Uchida D، Morimoto S (أغسطس 1997). "Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family". Biochem. J. ج. 326 ع. 1: 69–75. PMC:1218638. PMID:9337852.
^ "Entrez Gene: epiregulin". مؤرشف من الأصل في 2010-12-05.

قراءة متعمقة

Yamamoto T، Akisue T، Marui T، وآخرون (2004). "Expression of betacellulin, heparin-binding epidermal growth factor and epiregulin in human malignant fibrous histiocytoma". Anticancer Res. ج. 24 ع. 3b: 2007–10. PMID:15274392.
Li S، Takeuchi F، Wang JA، وآخرون (2008). "Mesenchymal-epithelial interactions involving epiregulin in tuberous sclerosis complex hamartomas". Proc. Natl. Acad. Sci. U.S.A. ج. 105 ع. 9: 3539–44. DOI:10.1073/pnas.0712397105. PMC:2265180. PMID:18292222.
Cho MC، Choi HS، Lee S، وآخرون (2008). "Epiregulin expression by Ets-1 and ERK signaling pathway in Ki-ras-transformed cells". Biochem. Biophys. Res. Commun. ج. 377 ع. 3: 832–7. DOI:10.1016/j.bbrc.2008.10.053. PMID:18948081.
Lindvall C، Hou M، Komurasaki T، وآخرون (2003). "Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling: activation of the epiregulin gene". Cancer Res. ج. 63 ع. 8: 1743–7. PMID:12702554.
Morita S، Shirakata Y، Shiraishi A، وآخرون (2007). "Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members". Mol. Vis. ج. 13: 2119–28. PMID:18079685.
Freimann S، Ben-Ami I، Dantes A، وآخرون (2004). "EGF-like factor epiregulin and amphiregulin expression is regulated by gonadotropins/cAMP in human ovarian follicular cells". Biochem. Biophys. Res. Commun. ج. 324 ع. 2: 829–34. DOI:10.1016/j.bbrc.2004.09.129. PMID:15474502.
Ben-Ami I، Armon L، Freimann S، وآخرون (2009). "EGF-like growth factors as LH mediators in the human corpus luteum". Hum. Reprod. ج. 24 ع. 1: 176–84. DOI:10.1093/humrep/den359. PMID:18835871.
Shigeishi H، Higashikawa K، Hiraoka M، وآخرون (2008). "Expression of epiregulin, a novel epidermal growth factor ligand associated with prognosis in human oral squamous cell carcinomas". Oncol. Rep. ج. 19 ع. 6: 1557–64. DOI:10.3892/or.19.6.1557. PMID:18497965.
Taylor DS، Cheng X، Pawlowski JE، وآخرون (1999). "Epiregulin is a potent vascular smooth muscle cell-derived mitogen induced by angiotensin II, endothelin-1, and thrombin". Proc. Natl. Acad. Sci. U.S.A. ج. 96 ع. 4: 1633–8. DOI:10.1073/pnas.96.4.1633. PMC:15542. PMID:9990076.
Zhang J، Iwanaga K، Choi KC، وآخرون (2008). "Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells". Cancer Prev Res (Phila). ج. 1 ع. 3: 201–7. DOI:10.1158/1940-6207.CAPR-08-0014. PMC:3375599. PMID:19138957.
Draper BK، Komurasaki T، Davidson MK، Nanney LB (2003). "Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation". J. Cell. Biochem. ج. 89 ع. 6: 1126–37. DOI:10.1002/jcb.10584. PMID:12898511.
Révillion F، Lhotellier V، Hornez L، Bonneterre J، Peyrat JP (يناير 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and prognosis". Ann. Oncol. ج. 19 ع. 1: 73–80. DOI:10.1093/annonc/mdm431. PMID:17962208.
Ben-Ami I، Freimann S، Armon L، وآخرون (2006). "PGE2 up-regulates EGF-like growth factor biosynthesis in human granulosa cells: new insights into the coordination between PGE2 and LH in ovulation". Mol. Hum. Reprod. ج. 12 ع. 10: 593–9. DOI:10.1093/molehr/gal068. PMID:16888076.
Takahashi M، Hayashi K، Yoshida K، وآخرون (2003). "Epiregulin as a major autocrine/paracrine factor released from ERK- and p38MAPK-activated vascular smooth muscle cells". Circulation. ج. 108 ع. 20: 2524–9. DOI:10.1161/01.CIR.0000096482.02567.8C. PMID:14581411.
Lasky-Su J، Neale BM، Franke B، وآخرون (2008). "Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations". Am. J. Med. Genet. B Neuropsychiatr. Genet. ج. 147B ع. 8: 1345–54. DOI:10.1002/ajmg.b.30867. PMID:18821565.
Gupta GP، Nguyen DX، Chiang AC، وآخرون (2007). "Mediators of vascular remodelling co-opted for sequential steps in lung metastasis". Nature. ج. 446 ع. 7137: 765–70. DOI:10.1038/nature05760. PMID:17429393.
Shirakata Y، Komurasaki T، Toyoda H، وآخرون (2000). "Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes". J. Biol. Chem. ج. 275 ع. 8: 5748–53. DOI:10.1074/jbc.275.8.5748. PMID:10681561.{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link)