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Molecular virology

Was the 1918 flu avian in origin?

Abstract

Arising from: J. K. Taubenberger et al. Nature 437, 889–893 (2005); see also communication from Gibbs and Gibbs; Taubenberger et al. reply

Taubenberger et al.1 claim that the 1918 influenza virus was derived from an avian source and adapted to humans shortly before the pandemic. However, we do not believe that this conclusion, which has been widely disseminated in the popular press and in scientific journals2,3,4, is supported by their phylogenetic evidence.

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Figure 1: Neighbour-joining analysis of the PB1 subunit of the influenza virus A polymerase heterotrimer and of the peptide PB1–F2.

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References

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Correspondence to Janis Antonovics.

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Antonovics, J., Hood, M. & Baker, C. Was the 1918 flu avian in origin?. Nature 440, E9 (2006). https://doi.org/10.1038/nature04824

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