Template:PBB The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.[1][2][3]
The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization.
Diseases associated with ADI1 include Klebsiella, and refsum disease.
References
- ^ Uekita T, Gotoh I, Kinoshita T, Itoh Y, Sato H, Shiomi T, Okada Y, Seiki M (Mar 2004). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors". J Biol Chem. 279 (13): 12734–43. doi:10.1074/jbc.M309957200. PMID 14718544.
{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Hirano W, Gotoh I, Uekita T, Seiki M (Jun 2005). "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway". Genes Cells. 10 (6): 565–74. doi:10.1111/j.1365-2443.2005.00859.x. PMID 15938715.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: ADI1 acireductone dioxygenase 1".
Further reading
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