Papillomaviridae: Difference between revisions

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The papillomavirus capsid also contains a viral protein known as L2, which is less abundant. Although not clear how L2 is arranged within the virion, it is known to perform several important functions, including facilitating the packaging of the viral genome into nascent virions as well as the infectious entry of the virus into new host cells. L2 is of interest as a possible target for more broadly protective [[HPV vaccine]]s.
 
The viral capsid consists of 72 capsomeres of which 12 are five-coordinated and 60 are six-coordinated capsomeres, arranged on a T = 7d icosahedral surface lattice.<ref>{{cite journal |vauthors=Rayment I, Baker TS, Caspar DL, Murakami WT |title=Polyoma virus capsid structure at 22.5 A resolution |journal=Nature |volume=295 |issue=5845 |pages=110–5 |date=January 1982 |pmid=6276752 |pmc=4144041 |doi=10.1038/295110a0 |bibcode=1982Natur.295..110R }}</ref>
 
==Tissue specificity==
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