40S ribosomal protein S15

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.

RPS15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4UJC, 4D5L, 4UJE, 3J7P, 4V5Z, 4UJD
Identifiers
Aliases	RPS15, RIG, S15, ribosomal protein S15
External IDs	OMIM: 180535; MGI: 98117; HomoloGene: 110643; GeneCards: RPS15; OMA:RPS15 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 1,438,358 bp End 1,440,495 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 C1 Start 80,128,287 bp End 80,129,948 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pituitary Gland anterior pituitary right hemisphere of cerebellum skin of abdomen skin of leg left ovary right ovary prostate right uterine tube Amygdala Top expressed in efferent ductule transitional epithelium of urinary bladder internal carotid artery abdominal wall medial ganglionic eminence mesenteric lymph nodes maxillary prominence migratory enteric neural crest cell dermis cervix More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding structural constituent of ribosome protein binding RNA binding Cellular component cytosol ribosome membrane focal adhesion cytosolic small ribosomal subunit small ribosomal subunit nucleus nucleoplasm Biological process ribosomal small subunit export from nucleus viral transcription SRP-dependent cotranslational protein targeting to membrane osteoblast differentiation translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ribosomal small subunit biogenesis ribosomal small subunit assembly protein biosynthesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6209 20054 Ensembl ENSG00000115268 ENSMUSG00000063457 UniProt P62841 P62843 RefSeq (mRNA) NM_001018 NM_001308226 NM_009091 NM_001310726 RefSeq (protein) NP_001009 NP_001295155 NP_001297655 NP_033117 Location (UCSC) Chr 19: 1.44 – 1.44 Mb Chr 10: 80.13 – 80.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Kitagawa M, Takasawa S, Kikuchi N, et al. (1991). "rig encodes ribosomal protein S15. The primary structure of mammalian ribosomal protein S15". FEBS Lett. 283 (2): 210–4. Bibcode:1991FEBSL.283..210K. doi:10.1016/0014-5793(91)80590-Y. PMID 2044758. S2CID 2687455.
• Inoue C, Shiga K, Takasawa S, et al. (1987). "Evolutionary conservation of the insulinoma gene rig and its possible function". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6659–62. Bibcode:1987PNAS...84.6659I. doi:10.1073/pnas.84.19.6659. PMC 299142. PMID 2821540.
• Marion MJ, Marion C (1988). "Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin". FEBS Lett. 232 (2): 281–5. Bibcode:1988FEBSL.232..281M. doi:10.1016/0014-5793(88)80753-1. PMID 3378620. S2CID 44333810.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human 40S ribosomal protein S15