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Protein-coding gene in humans
Carboxypeptidase A5 is an enzyme that in humans is encoded by the CPA5 gene .[ 5] [ 6]
Carboxypeptidases have functions ranging from digestion of food to selective biosynthesis of neuroendocrine peptides. Members of the A/B subfamily of carboxypeptidases, such as CPA5, contain an approximately 90-amino acid pro region that assists in the folding of the active carboxypeptidase domain. Cleavage of the pro region activates the enzyme (Wei et al., 2002).[supplied by OMIM][ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000158525 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029788 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wei S, Segura S, Vendrell J, Aviles FX, Lanoue E, Day R, Feng Y, Fricker LD (Apr 2002). "Identification and characterization of three members of the human metallocarboxypeptidase gene family" . J Biol Chem . 277 (17): 14954– 64. doi :10.1074/jbc.M112254200 PMID 11836249 . ^ a b "Entrez Gene: CPA5 carboxypeptidase A5" .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40– 5. doi :10.1038/ng1285 PMID 14702039 . Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7" . Nature . 424 (6945): 157– 64. Bibcode :2003Natur.424..157H . doi :10.1038/nature01782 PMID 12853948 . Bentley L, Nakabayashi K, Monk D, et al. (2003). "The imprinted region on human chromosome 7q32 extends to the carboxypeptidase A gene cluster: an imprinted candidate for Silver-Russell syndrome" . J. Med. Genet . 40 (4): 249– 56. doi :10.1136/jmg.40.4.249 . PMC 1735416 PMID 12676894 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Bonora E, Bacchelli E, Levy ER, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Mol. Psychiatry . 7 (3): 289– 301. doi :10.1038/sj.mp.4001004 . PMID 11920156 . S2CID 13282515 . "A full genome screen for autism with evidence for linkage to a region on chromosome 7q. International Molecular Genetic Study of Autism Consortium" . Hum. Mol. Genet . 7 (3): 571– 8. 1998. doi :10.1093/hmg/7.3.571 hdl :11858/00-001M-0000-0012-C9D8-C PMID 9546821 .
