diff --git a/.semaphore/semaphore.yml b/.semaphore/semaphore.yml
index 0b194c7f9..3a6b27126 100644
--- a/.semaphore/semaphore.yml
+++ b/.semaphore/semaphore.yml
@@ -8,7 +8,7 @@ execution_time_limit:
 global_job_config:
   env_vars:
     - name: LIBRDKAFKA_VERSION
-      value: v2.10.1-RC1
+      value: v2.10.1
   prologue:
     commands:
       - checkout
diff --git a/CHANGELOG.md b/CHANGELOG.md
index a0338d1bf..634b1f7a9 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -2,11 +2,16 @@
 
 ## v2.10.1
 
-v2.10.0 is a fix release with the following fixes
+v2.10.1 is a maintenance release with the following fixes
 
 - Handled `None` value for optional `ctx` parameter in  `ProtobufDeserializer` (#1939)
 - Handled `None` value for optional `ctx` parameter in  `AvroDeserializer` (#1973)
 
+confluent-kafka-python v2.10.1 is based on librdkafka v2.10.1, see the
+[librdkafka release notes](https://github.com/confluentinc/librdkafka/releases/tag/v2.10.1)
+for a complete list of changes, enhancements, fixes and upgrade considerations.
+
+
 ## v2.10.0
 
 v2.10.0 is a feature release with the following fixes and enhancements:
diff --git a/docs/conf.py b/docs/conf.py
index 474ccea34..d5e0f3ccc 100644
--- a/docs/conf.py
+++ b/docs/conf.py
@@ -27,7 +27,7 @@
 # built documents.
 #
 # The short X.Y version.
-version = '2.10.1rc1'
+version = '2.10.1'
 # The full version, including alpha/beta/rc tags.
 release = version
 ######################################################################
diff --git a/examples/docker/Dockerfile.alpine b/examples/docker/Dockerfile.alpine
index 1c4b36c48..a6bce3907 100644
--- a/examples/docker/Dockerfile.alpine
+++ b/examples/docker/Dockerfile.alpine
@@ -30,7 +30,7 @@ FROM alpine:3.12
 
 COPY . /usr/src/confluent-kafka-python
 
-ENV LIBRDKAFKA_VERSION="v2.10.1-RC1"
+ENV LIBRDKAFKA_VERSION="v2.10.1"
 ENV KCAT_VERSION="master"
 ENV CKP_VERSION="master"
 
diff --git a/pyproject.toml b/pyproject.toml
index 049a77c4e..cd6106ff3 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -4,7 +4,7 @@ build-backend = "setuptools.build_meta"
 
 [project]
 name = "confluent-kafka"
-version = "2.10.1rc1"
+version = "2.10.1"
 description = "Confluent's Python client for Apache Kafka"
 classifiers = [
     "Development Status :: 5 - Production/Stable",
diff --git a/src/confluent_kafka/src/confluent_kafka.h b/src/confluent_kafka/src/confluent_kafka.h
index 712bf0008..213bba7dc 100644
--- a/src/confluent_kafka/src/confluent_kafka.h
+++ b/src/confluent_kafka/src/confluent_kafka.h
@@ -43,7 +43,7 @@
  *  MM=major, mm=minor, RR=revision, PP=patchlevel (not used)
  */
 #define CFL_VERSION     0x020a0100
-#define CFL_VERSION_STR "2.10.1rc1"
+#define CFL_VERSION_STR "2.10.1"
 
 /**
  * Minimum required librdkafka version. This is checked both during
@@ -51,19 +51,19 @@
  * Make sure to keep the MIN_RD_KAFKA_VERSION, MIN_VER_ERRSTR and #error
  * defines and strings in sync.
  */
-#define MIN_RD_KAFKA_VERSION 0x020a00ff
+#define MIN_RD_KAFKA_VERSION 0x020a01ff
 
 #ifdef __APPLE__
-#define MIN_VER_ERRSTR "confluent-kafka-python requires librdkafka v2.10.0 or later. Install the latest version of librdkafka from Homebrew by running `brew install librdkafka` or `brew upgrade librdkafka`"
+#define MIN_VER_ERRSTR "confluent-kafka-python requires librdkafka v2.10.1 or later. Install the latest version of librdkafka from Homebrew by running `brew install librdkafka` or `brew upgrade librdkafka`"
 #else
-#define MIN_VER_ERRSTR "confluent-kafka-python requires librdkafka v2.10.0 or later. Install the latest version of librdkafka from the Confluent repositories, see http://docs.confluent.io/current/installation.html"
+#define MIN_VER_ERRSTR "confluent-kafka-python requires librdkafka v2.10.1 or later. Install the latest version of librdkafka from the Confluent repositories, see http://docs.confluent.io/current/installation.html"
 #endif
 
 #if RD_KAFKA_VERSION < MIN_RD_KAFKA_VERSION
 #ifdef __APPLE__
-#error "confluent-kafka-python requires librdkafka v2.10.0 or later. Install the latest version of librdkafka from Homebrew by running `brew install librdkafka` or `brew upgrade librdkafka`"
+#error "confluent-kafka-python requires librdkafka v2.10.1 or later. Install the latest version of librdkafka from Homebrew by running `brew install librdkafka` or `brew upgrade librdkafka`"
 #else
-#error "confluent-kafka-python requires librdkafka v2.10.0 or later. Install the latest version of librdkafka from the Confluent repositories, see http://docs.confluent.io/current/installation.html"
+#error "confluent-kafka-python requires librdkafka v2.10.1 or later. Install the latest version of librdkafka from the Confluent repositories, see http://docs.confluent.io/current/installation.html"
 #endif
 #endif
 

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