diff --git a/lib/matplotlib/backends/backend_qt5agg.py b/lib/matplotlib/backends/backend_qt5agg.py
index 826156e67843..d2166d58c88f 100644
--- a/lib/matplotlib/backends/backend_qt5agg.py
+++ b/lib/matplotlib/backends/backend_qt5agg.py
@@ -68,7 +68,7 @@ def paintEvent(self, e):
             if hasattr(qimage, 'setDevicePixelRatio'):
                 # Not available on Qt4 or some older Qt5.
                 qimage.setDevicePixelRatio(self._dpi_ratio)
-            origin = QtCore.QPoint(l, self.renderer.height - t)
+            origin = QtCore.QPoint(int(l), int(self.renderer.height - t))
             painter.drawImage(origin / self._dpi_ratio, qimage)
 
         self._draw_rect_callback(painter)
diff --git a/lib/matplotlib/backends/qt_editor/figureoptions.py b/lib/matplotlib/backends/qt_editor/figureoptions.py
index 40572c8bd827..f0050d367502 100644
--- a/lib/matplotlib/backends/qt_editor/figureoptions.py
+++ b/lib/matplotlib/backends/qt_editor/figureoptions.py
@@ -222,7 +222,7 @@ def apply_callback(data):
             rgba = mcolors.to_rgba(color)
             line.set_alpha(None)
             line.set_color(rgba)
-            if marker is not 'none':
+            if marker != 'none':
                 line.set_marker(marker)
                 line.set_markersize(markersize)
                 line.set_markerfacecolor(markerfacecolor)
diff --git a/lib/matplotlib/contour.py b/lib/matplotlib/contour.py
index b2ebfc11eb53..e03bdaeae657 100644
--- a/lib/matplotlib/contour.py
+++ b/lib/matplotlib/contour.py
@@ -870,7 +870,7 @@ def __init__(self, ax, *args, **kwargs):
             self.logscale = True
             if norm is None:
                 norm = colors.LogNorm()
-            if self.extend is not 'neither':
+            if self.extend != 'neither':
                 raise ValueError('extend kwarg does not work yet with log '
                                  ' scale')
         else:
diff --git a/lib/matplotlib/font_manager.py b/lib/matplotlib/font_manager.py
index 5900fc9b1841..2ba1a50638ee 100644
--- a/lib/matplotlib/font_manager.py
+++ b/lib/matplotlib/font_manager.py
@@ -43,8 +43,10 @@
             The font directory code is from ttfquery,
             see license/LICENSE_TTFQUERY.
 """
-
-from collections import Iterable
+try:
+    from collections.abc import Iterable
+except ImportError:
+    from collections import Iterable
 import json
 import os
 import sys
diff --git a/lib/matplotlib/pyplot.py b/lib/matplotlib/pyplot.py
index fb5928dc65ff..22411701c98e 100644
--- a/lib/matplotlib/pyplot.py
+++ b/lib/matplotlib/pyplot.py
@@ -2419,7 +2419,7 @@ def matshow(A, fignum=None, **kwargs):
 
     """
     A = np.asanyarray(A)
-    if fignum is False or fignum is 0:
+    if fignum is False or fignum == 0:
         ax = gca()
     else:
         # Extract actual aspect ratio of array and make appropriately sized figure
diff --git a/src/_macosx.m b/src/_macosx.m
index 8f44f1eb0c54..0d337e7e0d17 100644
--- a/src/_macosx.m
+++ b/src/_macosx.m
@@ -1,3 +1,4 @@
+#define PY_SSIZE_T_CLEAN
 #include <Cocoa/Cocoa.h>
 #include <ApplicationServices/ApplicationServices.h>
 #include <sys/socket.h>
diff --git a/src/_png.cpp b/src/_png.cpp
index 547e6b026699..ea7bf32efee3 100644
--- a/src/_png.cpp
+++ b/src/_png.cpp
@@ -5,7 +5,7 @@
    Undefining _POSIX_C_SOURCE and _XOPEN_SOURCE stops a couple
    of harmless warnings.
 */
-
+#define PY_SSIZE_T_CLEAN
 
 extern "C" {
 #   include <png.h>
diff --git a/src/_tkagg.cpp b/src/_tkagg.cpp
index ad5289b3d6eb..106f1398b306 100644
--- a/src/_tkagg.cpp
+++ b/src/_tkagg.cpp
@@ -7,7 +7,7 @@
  * See LICENSE/LICENSE.PIL for details.
  *
  */
-
+#define PY_SSIZE_T_CLEAN
 #include <Python.h>
 #include <cstdlib>
 #include <cstdio>
diff --git a/src/_ttconv.cpp b/src/_ttconv.cpp
index e0aa4611d28d..e18c8a53cab8 100644
--- a/src/_ttconv.cpp
+++ b/src/_ttconv.cpp
@@ -5,7 +5,7 @@
 
   Python wrapper for TrueType conversion library in ../ttconv.
  */
-
+#define PY_SSIZE_T_CLEAN
 #include "mplutils.h"
 
 #include <Python.h>
diff --git a/src/file_compat.h b/src/file_compat.h
index 691133dcbb7f..114279fb1a14 100644
--- a/src/file_compat.h
+++ b/src/file_compat.h
@@ -1,6 +1,6 @@
 #ifndef __FILE_COMPAT_H__
 #define __FILE_COMPAT_H__
-
+#define PY_SSIZE_T_CLEAN
 #include <Python.h>
 #include <stdio.h>
 #include "numpy/npy_common.h"
diff --git a/src/ft2font.h b/src/ft2font.h
index c60d5432cff6..072428ceedbe 100644
--- a/src/ft2font.h
+++ b/src/ft2font.h
@@ -18,8 +18,8 @@ extern "C" {
 /*
  By definition, FT_FIXED as 2 16bit values stored in a single long.
  */
-#define FIXED_MAJOR(val) (long)((val & 0xffff000) >> 16)
-#define FIXED_MINOR(val) (long)(val & 0xffff)
+#define FIXED_MAJOR(val) (signed short)((val & 0xffff0000) >> 16)
+#define FIXED_MINOR(val) (unsigned short)(val & 0xffff)
 
 // the FreeType string rendered into a width, height buffer
 class FT2Image
diff --git a/src/ft2font_wrapper.cpp b/src/ft2font_wrapper.cpp
index 49c33b794357..d0e516ad0252 100644
--- a/src/ft2font_wrapper.cpp
+++ b/src/ft2font_wrapper.cpp
@@ -276,7 +276,7 @@ static void PyGlyph_dealloc(PyGlyph *self)
 static PyObject *PyGlyph_get_bbox(PyGlyph *self, void *closure)
 {
     return Py_BuildValue(
-        "iiii", self->bbox.xMin, self->bbox.yMin, self->bbox.xMax, self->bbox.yMax);
+        "llll", self->bbox.xMin, self->bbox.yMin, self->bbox.xMax, self->bbox.yMax);
 }
 
 static PyTypeObject *PyGlyph_init_type(PyObject *m, PyTypeObject *type)
@@ -1026,7 +1026,7 @@ static PyObject *PyFT2Font_get_sfnt(PyFT2Font *self, PyObject *args, PyObject *k
         }
 
         PyObject *key = Py_BuildValue(
-            "iiii", sfnt.platform_id, sfnt.encoding_id, sfnt.language_id, sfnt.name_id);
+            "HHHH", sfnt.platform_id, sfnt.encoding_id, sfnt.language_id, sfnt.name_id);
         if (key == NULL) {
             Py_DECREF(names);
             return NULL;
@@ -1090,7 +1090,7 @@ static PyObject *PyFT2Font_get_ps_font_info(PyFT2Font *self, PyObject *args, PyO
         return NULL;
     }
 
-    return Py_BuildValue("sssssliii",
+    return Py_BuildValue("ssssslbhH",
                          fontinfo.version ? fontinfo.version : "",
                          fontinfo.notice ? fontinfo.notice : "",
                          fontinfo.full_name ? fontinfo.full_name : "",
@@ -1135,8 +1135,8 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
     switch (tag) {
     case 0: {
         char head_dict[] =
-            "{s:(h,h), s:(h,h), s:l, s:l, s:i, s:i,"
-            "s:(l,l), s:(l,l), s:h, s:h, s:h, s:h, s:i, s:i, s:h, s:h, s:h}";
+            "{s:(h,H), s:(h,H), s:l, s:l, s:H, s:H,"
+            "s:(l,l), s:(l,l), s:h, s:h, s:h, s:h, s:H, s:H, s:h, s:h, s:h}";
         TT_Header *t = (TT_Header *)table;
         return Py_BuildValue(head_dict,
                              "version",
@@ -1150,9 +1150,9 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "magicNumber",
                              t->Magic_Number,
                              "flags",
-                             (unsigned)t->Flags,
+                             t->Flags,
                              "unitsPerEm",
-                             (unsigned)t->Units_Per_EM,
+                             t->Units_Per_EM,
                              "created",
                              t->Created[0],
                              t->Created[1],
@@ -1168,9 +1168,9 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "yMax",
                              t->yMax,
                              "macStyle",
-                             (unsigned)t->Mac_Style,
+                             t->Mac_Style,
                              "lowestRecPPEM",
-                             (unsigned)t->Lowest_Rec_PPEM,
+                             t->Lowest_Rec_PPEM,
                              "fontDirectionHint",
                              t->Font_Direction,
                              "indexToLocFormat",
@@ -1180,64 +1180,64 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
     }
     case 1: {
         char maxp_dict[] =
-            "{s:(h,h), s:i, s:i, s:i, s:i, s:i, s:i,"
-            "s:i, s:i, s:i, s:i, s:i, s:i, s:i, s:i}";
+            "{s:(h,H), s:H, s:H, s:H, s:H, s:H, s:H,"
+            "s:H, s:H, s:H, s:H, s:H, s:H, s:H, s:H}";
         TT_MaxProfile *t = (TT_MaxProfile *)table;
         return Py_BuildValue(maxp_dict,
                              "version",
                              FIXED_MAJOR(t->version),
                              FIXED_MINOR(t->version),
                              "numGlyphs",
-                             (unsigned)t->numGlyphs,
+                             t->numGlyphs,
                              "maxPoints",
-                             (unsigned)t->maxPoints,
+                             t->maxPoints,
                              "maxContours",
-                             (unsigned)t->maxContours,
+                             t->maxContours,
                              "maxComponentPoints",
-                             (unsigned)t->maxCompositePoints,
+                             t->maxCompositePoints,
                              "maxComponentContours",
-                             (unsigned)t->maxCompositeContours,
+                             t->maxCompositeContours,
                              "maxZones",
-                             (unsigned)t->maxZones,
+                             t->maxZones,
                              "maxTwilightPoints",
-                             (unsigned)t->maxTwilightPoints,
+                             t->maxTwilightPoints,
                              "maxStorage",
-                             (unsigned)t->maxStorage,
+                             t->maxStorage,
                              "maxFunctionDefs",
-                             (unsigned)t->maxFunctionDefs,
+                             t->maxFunctionDefs,
                              "maxInstructionDefs",
-                             (unsigned)t->maxInstructionDefs,
+                             t->maxInstructionDefs,
                              "maxStackElements",
-                             (unsigned)t->maxStackElements,
+                             t->maxStackElements,
                              "maxSizeOfInstructions",
-                             (unsigned)t->maxSizeOfInstructions,
+                             t->maxSizeOfInstructions,
                              "maxComponentElements",
-                             (unsigned)t->maxComponentElements,
+                             t->maxComponentElements,
                              "maxComponentDepth",
-                             (unsigned)t->maxComponentDepth);
+                             t->maxComponentDepth);
     }
     case 2: {
 #if PY3K
         char os_2_dict[] =
-            "{s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h,"
-            "s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:y#, s:(llll),"
-            "s:y#, s:h, s:h, s:h}";
+            "{s:H, s:h, s:H, s:H, s:H, s:h, s:h, s:h,"
+            "s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:y#, s:(kkkk),"
+            "s:y#, s:H, s:H, s:H}";
 #else
         char os_2_dict[] =
-            "{s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h,"
-            "s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:s#, s:(llll),"
-            "s:s#, s:h, s:h, s:h}";
+            "{s:H, s:h, s:H, s:H, s:H, s:h, s:h, s:h,"
+            "s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:h, s:s#, s:(kkkk),"
+            "s:s#, s:H, s:H, s:H}";
 #endif
         TT_OS2 *t = (TT_OS2 *)table;
         return Py_BuildValue(os_2_dict,
                              "version",
-                             (unsigned)t->version,
+                             t->version,
                              "xAvgCharWidth",
                              t->xAvgCharWidth,
                              "usWeightClass",
-                             (unsigned)t->usWeightClass,
+                             t->usWeightClass,
                              "usWidthClass",
-                             (unsigned)t->usWidthClass,
+                             t->usWidthClass,
                              "fsType",
                              t->fsType,
                              "ySubscriptXSize",
@@ -1264,26 +1264,26 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              t->sFamilyClass,
                              "panose",
                              t->panose,
-                             10,
+                             Py_ssize_t(10),
                              "ulCharRange",
-                             (unsigned long)t->ulUnicodeRange1,
-                             (unsigned long)t->ulUnicodeRange2,
-                             (unsigned long)t->ulUnicodeRange3,
-                             (unsigned long)t->ulUnicodeRange4,
+                             t->ulUnicodeRange1,
+                             t->ulUnicodeRange2,
+                             t->ulUnicodeRange3,
+                             t->ulUnicodeRange4,
                              "achVendID",
                              t->achVendID,
-                             4,
+                             Py_ssize_t(4),
                              "fsSelection",
-                             (unsigned)t->fsSelection,
+                             t->fsSelection,
                              "fsFirstCharIndex",
-                             (unsigned)t->usFirstCharIndex,
+                             t->usFirstCharIndex,
                              "fsLastCharIndex",
-                             (unsigned)t->usLastCharIndex);
+                             t->usLastCharIndex);
     }
     case 3: {
         char hhea_dict[] =
-            "{s:(h,h), s:h, s:h, s:h, s:i, s:h, s:h, s:h,"
-            "s:h, s:h, s:h, s:h, s:i}";
+            "{s:(h,H), s:h, s:h, s:h, s:H, s:h, s:h, s:h,"
+            "s:h, s:h, s:h, s:h, s:H}";
         TT_HoriHeader *t = (TT_HoriHeader *)table;
         return Py_BuildValue(hhea_dict,
                              "version",
@@ -1296,7 +1296,7 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "lineGap",
                              t->Line_Gap,
                              "advanceWidthMax",
-                             (unsigned)t->advance_Width_Max,
+                             t->advance_Width_Max,
                              "minLeftBearing",
                              t->min_Left_Side_Bearing,
                              "minRightBearing",
@@ -1312,12 +1312,12 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "metricDataFormat",
                              t->metric_Data_Format,
                              "numOfLongHorMetrics",
-                             (unsigned)t->number_Of_HMetrics);
+                             t->number_Of_HMetrics);
     }
     case 4: {
         char vhea_dict[] =
-            "{s:(h,h), s:h, s:h, s:h, s:i, s:h, s:h, s:h,"
-            "s:h, s:h, s:h, s:h, s:i}";
+            "{s:(h,H), s:h, s:h, s:h, s:H, s:h, s:h, s:h,"
+            "s:h, s:h, s:h, s:h, s:H}";
         TT_VertHeader *t = (TT_VertHeader *)table;
         return Py_BuildValue(vhea_dict,
                              "version",
@@ -1330,7 +1330,7 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "vertTypoLineGap",
                              t->Line_Gap,
                              "advanceHeightMax",
-                             (unsigned)t->advance_Height_Max,
+                             t->advance_Height_Max,
                              "minTopSideBearing",
                              t->min_Top_Side_Bearing,
                              "minBottomSizeBearing",
@@ -1346,10 +1346,10 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              "metricDataFormat",
                              t->metric_Data_Format,
                              "numOfLongVerMetrics",
-                             (unsigned)t->number_Of_VMetrics);
+                             t->number_Of_VMetrics);
     }
     case 5: {
-        char post_dict[] = "{s:(h,h), s:(h,h), s:h, s:h, s:k, s:k, s:k, s:k, s:k}";
+        char post_dict[] = "{s:(h,H), s:(h,H), s:h, s:h, s:k, s:k, s:k, s:k, s:k}";
         TT_Postscript *t = (TT_Postscript *)table;
         return Py_BuildValue(post_dict,
                              "format",
@@ -1376,12 +1376,12 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
     case 6: {
         #if PY3K
         char pclt_dict[] =
-            "{s:(h,h), s:k, s:H, s:H, s:H, s:H, s:H, s:H, s:y, s:y, s:b, s:b, "
-            "s:b}";
+            "{s:(h,H), s:k, s:H, s:H, s:H, s:H, s:H, s:H, s:y#, s:y#, s:b, "
+            "s:b, s:b}";
         #else
         char pclt_dict[] =
-            "{s:(h,h), s:k, s:H, s:H, s:H, s:H, s:H, s:H, s:s, s:s, s:b, s:b, "
-            "s:b}";
+            "{s:(h,H), s:k, s:H, s:H, s:H, s:H, s:H, s:H, s:s#, s:s#, s:b, "
+            "s:b, s:b}";
         #endif
         TT_PCLT *t = (TT_PCLT *)table;
         return Py_BuildValue(pclt_dict,
@@ -1404,8 +1404,10 @@ static PyObject *PyFT2Font_get_sfnt_table(PyFT2Font *self, PyObject *args, PyObj
                              t->SymbolSet,
                              "typeFace",
                              t->TypeFace,
+                             Py_ssize_t(16),
                              "characterComplement",
                              t->CharacterComplement,
+                             Py_ssize_t(8),
                              "strokeWeight",
                              t->StrokeWeight,
                              "widthType",
@@ -1528,7 +1530,8 @@ static PyObject *PyFT2Font_get_bbox(PyFT2Font *self, void *closure)
 {
     FT_BBox *bbox = &(self->x->get_face()->bbox);
 
-    return Py_BuildValue("iiii", bbox->xMin, bbox->yMin, bbox->xMax, bbox->yMax);
+    return Py_BuildValue("llll",
+                         bbox->xMin, bbox->yMin, bbox->xMax, bbox->yMax);
 }
 
 static PyObject *PyFT2Font_ascender(PyFT2Font *self, void *closure)
diff --git a/src/mplutils.h b/src/mplutils.h
index 140a81563478..4b59e08bbd4b 100644
--- a/src/mplutils.h
+++ b/src/mplutils.h
@@ -4,6 +4,7 @@
 
 #ifndef _MPLUTILS_H
 #define _MPLUTILS_H
+#define PY_SSIZE_T_CLEAN
 
 #if defined(_MSC_VER) && _MSC_VER <= 1600
 typedef unsigned __int8   uint8_t;
diff --git a/src/numpy_cpp.h b/src/numpy_cpp.h
index 03b4a695d188..75f773ee58e2 100644
--- a/src/numpy_cpp.h
+++ b/src/numpy_cpp.h
@@ -2,7 +2,7 @@
 
 #ifndef _NUMPY_CPP_H_
 #define _NUMPY_CPP_H_
-
+#define PY_SSIZE_T_CLEAN
 /***************************************************************************
  * This file is based on original work by Mark Wiebe, available at:
  *
diff --git a/src/py_adaptors.h b/src/py_adaptors.h
index 8eaa7ad6c71d..3d0dbdab45b7 100644
--- a/src/py_adaptors.h
+++ b/src/py_adaptors.h
@@ -2,7 +2,7 @@
 
 #ifndef __PY_ADAPTORS_H__
 #define __PY_ADAPTORS_H__
-
+#define PY_SSIZE_T_CLEAN
 /***************************************************************************
  * This module contains a number of C++ classes that adapt Python data
  * structures to C++ and Agg-friendly interfaces.
diff --git a/src/py_converters.cpp b/src/py_converters.cpp
index c36fc59f59d9..2d5d415a2c9e 100644
--- a/src/py_converters.cpp
+++ b/src/py_converters.cpp
@@ -1,5 +1,5 @@
 #define NO_IMPORT_ARRAY
-
+#define PY_SSIZE_T_CLEAN
 #include "py_converters.h"
 #include "numpy_cpp.h"
 
diff --git a/src/qhull_wrap.c b/src/qhull_wrap.c
index e71afc7e3700..177e19fab0d9 100644
--- a/src/qhull_wrap.c
+++ b/src/qhull_wrap.c
@@ -5,6 +5,7 @@
  * triangulation, construct an instance of the matplotlib.tri.Triangulation
  * class without specifying a triangles array.
  */
+#define PY_SSIZE_T_CLEAN
 #include "Python.h"
 #include "numpy/noprefix.h"
 #include "libqhull/qhull_a.h"

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