diff --git a/Misc/NEWS.d/next/Build/2025-03-15-12-32-56.gh-issue-131278.1nd0mJ.rst b/Misc/NEWS.d/next/Build/2025-03-15-12-32-56.gh-issue-131278.1nd0mJ.rst
new file mode 100644
index 00000000000000..56e698383aa1ef
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2025-03-15-12-32-56.gh-issue-131278.1nd0mJ.rst
@@ -0,0 +1,2 @@
+Add optimizing flag ``WITH_COMPUTED_GOTOS`` to Windows builds for when
+using a compiler that supports it (currently clang-cl). Patch by Chris Eibl.
diff --git a/PCbuild/pythoncore.vcxproj b/PCbuild/pythoncore.vcxproj
index cef0e81e11972c..045d109d2820a1 100644
--- a/PCbuild/pythoncore.vcxproj
+++ b/PCbuild/pythoncore.vcxproj
@@ -107,6 +107,7 @@
_Py_JIT;%(PreprocessorDefinitions)_Py_TIER2=$(UseTIER2);%(PreprocessorDefinitions)Py_TAIL_CALL_INTERP=1;%(PreprocessorDefinitions)
+ HAVE_COMPUTED_GOTOS;%(PreprocessorDefinitions)version.lib;ws2_32.lib;pathcch.lib;bcrypt.lib;%(AdditionalDependencies)
diff --git a/PCbuild/readme.txt b/PCbuild/readme.txt
index 33952d31681cbc..8e82d4ea840fe1 100644
--- a/PCbuild/readme.txt
+++ b/PCbuild/readme.txt
@@ -310,6 +310,27 @@ See
for more on this topic.
+Optimization flags
+------------------
+
+You can set optimization flags either via
+
+* environment variables, for example:
+
+ set WITH_COMPUTED_GOTOS=true
+
+* or pass them as parameters to `build.bat`, for example:
+
+ build.bat "/p:WITH_COMPUTED_GOTOS=true"
+
+* or put them in `msbuild.rsp` in the `PCbuild` directory, one flag per line.
+
+Supported flags are:
+
+* WITH_COMPUTED_GOTOS: build the interpreter using "computed gotos".
+ Currently only supported by clang-cl.
+
+
Static library
--------------
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