diff --git a/Objects/listobject.c b/Objects/listobject.c
index 904bea317c9da8..37fadca129ac02 100644
--- a/Objects/listobject.c
+++ b/Objects/listobject.c
@@ -98,8 +98,15 @@ list_preallocate_exact(PyListObject *self, Py_ssize_t size)
/* Empty list reuse scheme to save calls to malloc and free */
#ifndef PyList_MAXFREELIST
-#define PyList_MAXFREELIST 80
+# define PyList_MAXFREELIST 80
#endif
+
+/* bpo-40521: list free lists are shared by all interpreters. */
+#ifdef EXPERIMENTAL_ISOLATED_SUBINTERPRETERS
+# undef PyList_MAXFREELIST
+# define PyList_MAXFREELIST 0
+#endif
+
static PyListObject *free_list[PyList_MAXFREELIST];
static int numfree = 0;
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