diff --git a/Misc/NEWS.d/next/Core and Builtins/2021-05-06-10-53-47.bpo-44060.ScfYXD.rst b/Misc/NEWS.d/next/Core and Builtins/2021-05-06-10-53-47.bpo-44060.ScfYXD.rst
new file mode 100644
index 00000000000000..7114d929225f75
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2021-05-06-10-53-47.bpo-44060.ScfYXD.rst
@@ -0,0 +1,2 @@
+The TARGET_#op label is now available even when computed gotos aren't
+enabled.
diff --git a/Python/ceval.c b/Python/ceval.c
index 25548e34db246b..e2c5a381f03fa3 100644
--- a/Python/ceval.c
+++ b/Python/ceval.c
@@ -1296,11 +1296,15 @@ eval_frame_handle_pending(PyThreadState *tstate)
#define USE_COMPUTED_GOTOS 0
#endif
-#if USE_COMPUTED_GOTOS
+#if USE_COMPUTED_GOTOS || defined(Py_DEBUG)
#define TARGET(op) op: TARGET_##op
-#define DISPATCH_GOTO() goto *opcode_targets[opcode]
#else
#define TARGET(op) op
+#endif
+
+#if USE_COMPUTED_GOTOS
+#define DISPATCH_GOTO() goto *opcode_targets[opcode]
+#else
#define DISPATCH_GOTO() goto dispatch_opcode
#endif
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