diff --git a/setup.rst b/setup.rst
index a775f30ec..32dcfec2a 100644
--- a/setup.rst
+++ b/setup.rst
@@ -385,17 +385,20 @@ for the header and library files to your ``configure`` command. For example,
with **Homebrew**::
- $ brew install pkg-config openssl xz gdbm
+ $ brew install pkg-config openssl xz gdbm tcl-tk
-and ``configure`` Python versions >= 3.7::
+For Python 3.10 and newer::
- ./configure --with-pydebug --with-openssl=$(brew --prefix openssl)
+ $ PKG_CONFIG_PATH="$(brew --prefix tcl-tk)/lib/pkgconfig" \
+ ./configure --with-pydebug --with-openssl=$(brew --prefix openssl)
-or ``configure`` Python versions < 3.7::
+For Python versions 3.9 through 3.7::
- $ CPPFLAGS="-I$(brew --prefix openssl)/include" \
- LDFLAGS="-L$(brew --prefix openssl)/lib" \
- ./configure --with-pydebug
+ $ export PKG_CONFIG_PATH="$(brew --prefix tcl-tk)/lib/pkgconfig"
+ $ ./configure --with-pydebug \
+ --with-openssl=$(brew --prefix openssl) \
+ --with-tcltk-libs="$(pkg-config --libs tcl tk)" \
+ --with-tcltk-includes="$(pkg-config --cflags tcl tk)"
and ``make``::
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