Abstract.
We discuss a biophysical model of synaptic plasticity that provides a unified view of the outcomes of synaptic modification protocols, including: (1) prescribed time courses of postsynaptic intracellular Ca2+ release, (2) postsynaptic voltage clamping with presentation of presynaptic spike trains at various frequencies, (3) direct postsynaptic response to presynaptic spike trains at various frequencies, and (4) LTP/LTD as a response to precisely timed presynaptic and postsynaptic spikes.
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Acknowledgments.
We are very grateful to A. Selverston, D. Feldman, and C. Stevens for conversations about this work. This work was partially supported by the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Engineering and Geosciences, under Grant No. DE-FG03-90ER14138 and No. DE-FG03-96ER14592, by Grant NSF PHY0097134 from the National Science Foundation, by Grant DAAD19-01-1-0026 from the Army Research Office, by Grant N00014-00-1-0181 from the Office of Naval Research, and by Grant NIH R01 NS40110-01A2 from the National Institutes of Health. Also, this work was partially supported by M. Ciencia y Tecnología BFI2000-0157 (R. H.).
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Abarbanel, H., Gibb, L., Huerta, R. et al. Biophysical model of synaptic plasticity dynamics. Biol. Cybern. 89, 214–226 (2003). https://doi.org/10.1007/s00422-003-0422-x
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DOI: https://doi.org/10.1007/s00422-003-0422-x