Human Health Risk Consideration of Nano-Enabled Pesticides for Industry and Regulators
Previous IUPAC Nanopesticides projects (e.g., projects 2012-020-3-600 and 2016-016-2-600) have developed risk assessment frameworks and key criteria that could help risk assessment processes for nano-enabled pesticides (especially for ecological risk assessments) [1, 2].
While the approach elucidated in the above IUPAC projects is now being considered by regulatory agencies internationally (e.g., US EPA, Environment Canada, APVMA Australia, EFSA Europe), there is a need to expand our thinking and provide more practical information to answer some key questions, such as those listed below:
When a new product is presented to regulators, what are the key questions that they would like to ask? This essentially defines the problem formulation step in the health risk assessment framework.
What are the key characterization and analytical requirements for the specific product that may be necessary to answer the questions posed as part of Question 1 for a specific product type?
What are the specific methods or approaches for human health effects that are readily available and appropriate to answer the questions for the specific product under consideration?
What are the current knowledge gaps and uncertainties that the regulators and industry need to consider for a pragmatic approach to decision making?
This project would consist of three phases.
Phase I – Bring together a core group of task members to define the scope of the project, identify specific active ingredients and product types, and undertake problem formulation from the risk assessment perspective.
Phase II – Organize a workshop bringing together expertise from industry, regulatory bodies, and researchers on human health effects and the risk assessment of nano-enabled pesticides, as well as the characterization of nanomaterials that have been identified in phase I.
Phase III – Recommend a sound methodological approach for generating data that is likely to be needed by the regulators. Identify research priorities where current knowledge or methodology are found to be inadequate.
The overall objective is to assist industry, contract research organizations (CROs), and regulators in determining an acceptable and practicable approach for generating the data relevant to human health risk assessment required for the registration of nano-enabled pesticide formulations. Broadly speaking, a nano-enabled pesticide represents a product where nanotechnology is employed (e.g. delivery via a nano-carrier) to enhance efficacy, reduce the environmental footprint, or the enhance usability of a pesticide active ingredient.
For further information, contact the Task Group Chair Linda Johnston <linda.johnston@nrc-cnrc.gc.ca> or Rai Kookana <rai.kookana@csiro.au>
References
1. Rai Kookana et al. Nanopesticides: Guiding Principles for Regulatory Evaluation of Environmental Risks. J. Ag Food Chem 62:4227-4240. 2014. http://doi.org/10.1021/jf500232f)10.1021/jf500232fSearch in Google Scholar PubMed
2. Glen W. Walker et al. Ecological Risk Assessment of Nano-enabled Pesticides: A Perspective on Problem Formulation. J. Ag Food Chem. 2017. http://doi.org/10.1021/acs.jafc.7b0237310.1021/acs.jafc.7b02373Search in Google Scholar PubMed PubMed Central
©2018 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles in the same Issue
- Masthead - Full issue pdf
- Past President's Column
- A Good Beginning Makes a Good Ending
- Features
- Jamaican Chemists in Early Global Communication
- Everything Flows: Continuous Micro-Flow for Pharmaceutical Production
- Health for All in Dhaka: CHEMRAWN helps establish an International Centre for Natural Product Research
- Chemistry and Cultural Heritage*
- IUPAC Offers an Open Door to Chemists of the World*—A Program Revisited
- IUPAC Wire
- Sixth Polymer International–IUPAC Award goes to Cyrille Boyer
- Peter D.J. Grootenhuis is Awarded the 2018 IUPAC-Richter Prize
- The United Nations Proclaims the International Year of the Periodic Table of Chemical Elements
- World Metrology Day, 20 May 2018
- Science for Peace
- Resolution on the Water Crisis in Gaza
- The Chemical Weapons Convention: From Disarmament to Sustainable Development
- Project Place
- Interdivisional Discussion of Critical Evaluation of Chemistry Data
- Middle east regional cooperation and sustainable water management of transboundary water
- Chemical and Biochemical Thermodynamics Reunification
- Chemistry Teacher International
- Human Health Risk Consideration of Nano-Enabled Pesticides for Industry and Regulators
- IUPAC100 Periodic Table Challenge
- Making an imPACt
- Definition of the mole (IUPAC Recommendation 2017)
- On the future revision of the SI
- Reactions/comments to the new definition of the mole
- Terminology of separation methods (IUPAC Recommendations 2017)
- Interpreting and propagating the uncertainty of the standard atomic weights (IUPAC Technical Report)
- Mass and volume in analytical chemistry (IUPAC Technical Report)
- Risk assessment of effects of cadmium on human health (IUPAC Technical Report)
- Vocabulary on nominal property, examination, and related concepts for clinical laboratory sciences (IFCC-IUPAC Recommendations 2017)
- Bookworm
- “Speciation” Chemistry: Overdue for a Resurgence
- IUPAC Silver book—corrigendum
- Conference Call
- Chemistry and the Environment
- Advanced Materials (POLYCHAR2017)
- Bioorganic Chemistry in an Interdisciplinary Context
- Where 2B & Y
- Stamps International
- Cultural Heritage Chemistry
- Mark Your Calendar
Articles in the same Issue
- Masthead - Full issue pdf
- Past President's Column
- A Good Beginning Makes a Good Ending
- Features
- Jamaican Chemists in Early Global Communication
- Everything Flows: Continuous Micro-Flow for Pharmaceutical Production
- Health for All in Dhaka: CHEMRAWN helps establish an International Centre for Natural Product Research
- Chemistry and Cultural Heritage*
- IUPAC Offers an Open Door to Chemists of the World*—A Program Revisited
- IUPAC Wire
- Sixth Polymer International–IUPAC Award goes to Cyrille Boyer
- Peter D.J. Grootenhuis is Awarded the 2018 IUPAC-Richter Prize
- The United Nations Proclaims the International Year of the Periodic Table of Chemical Elements
- World Metrology Day, 20 May 2018
- Science for Peace
- Resolution on the Water Crisis in Gaza
- The Chemical Weapons Convention: From Disarmament to Sustainable Development
- Project Place
- Interdivisional Discussion of Critical Evaluation of Chemistry Data
- Middle east regional cooperation and sustainable water management of transboundary water
- Chemical and Biochemical Thermodynamics Reunification
- Chemistry Teacher International
- Human Health Risk Consideration of Nano-Enabled Pesticides for Industry and Regulators
- IUPAC100 Periodic Table Challenge
- Making an imPACt
- Definition of the mole (IUPAC Recommendation 2017)
- On the future revision of the SI
- Reactions/comments to the new definition of the mole
- Terminology of separation methods (IUPAC Recommendations 2017)
- Interpreting and propagating the uncertainty of the standard atomic weights (IUPAC Technical Report)
- Mass and volume in analytical chemistry (IUPAC Technical Report)
- Risk assessment of effects of cadmium on human health (IUPAC Technical Report)
- Vocabulary on nominal property, examination, and related concepts for clinical laboratory sciences (IFCC-IUPAC Recommendations 2017)
- Bookworm
- “Speciation” Chemistry: Overdue for a Resurgence
- IUPAC Silver book—corrigendum
- Conference Call
- Chemistry and the Environment
- Advanced Materials (POLYCHAR2017)
- Bioorganic Chemistry in an Interdisciplinary Context
- Where 2B & Y
- Stamps International
- Cultural Heritage Chemistry
- Mark Your Calendar
