Lois Chiles is a former supermodel-turned-actress who gave elegant performances in a variety of films throughout the 1970s and 1980s. Her motion picture debut role was as Robert Redford's sexual endeavor in the old-fashioned Hollywood melodrama, The Way We Were (1973). Shortly after, she starred opposite Clifton Davis in the indie blaxploitation film, Together for Days (1972); they portrayed a mixed-race couple enduring societal disapproval and political pandemonium. She also appeared as the irreverent socialite Jordan Baker in The Great Gatsby (1974), in which she starred alongside Mia Farrow and, again, Robert Redford.

Chiles delivered a series of pivotal characters particularly as a woman who mysteriously falls into a state of unconsciousness after entering the hospital for an early term abortion in Coma (1978), and as an impudent heiress and murder victim in the center of Death on the Nile (1978).

Chiles' most recognized role is the sophisticated NASA astronaut, scientist, and "Bond girl", Dr. Holly Goodhead opposite Roger Moore's James Bond in Moonraker (1979). It is worth noting that Goodhead was different than any previous "Bond girl", in that she was dignified and not so much sexualized. Sadly, that same year, just as Chiles' career was at its height, she lost her youngest brother to non-Hodgkin's lymphoma which resulted in her three-year hiatus from acting. Her career never fully recovered and she struggled to find roles that necessitated her individuality but she persevered and received positive reviews for her continued performances in film and television, particularly in Sweet Liberty (1986), Broadcast News (1987), Creepshow 2 (1987), Diary of a Hitman (1991) and Curdled (1996).

In recent years, she's appeared in a few television sitcoms, participated in interviews recalling her experience as a "Bond girl", and taught an acting class at the University of Houston.