Andre was born in Chicago, but grew up in Arizona, where the dark night skies encouraged his love of astronomy and space science. He holds a B.S. in physics, and a Master's in science, technology and space policy, earned under a NASA Space Grant Fellowship at The George Washington University. He became the science consultant for the Star Trek TV and film franchise in 1993, and was soon writing episodes of Star Trek: Voyager. He became a full-time writer and eventually co-producer on Star Trek: Enterprise. He then served as a writer-producer on the CBS TV series Threshold and Eleventh Hour, the syndicated series Legend of the Seeker, and Disney XD's Tron: Uprising. He worked as a writer and consulting producer on the FOX / National Geographic production of Cosmos, and as a writer and co-executive producer of the National Geographic miniseries Mars. He is a writer and co-executive producer on the Hulu series The Orville, and a writer and co-executive producer on the NBCU / Peacock series The End is Nye. He also serves on the board of directors of the Griffith Observatory fund-raising nonprofit organization, Friends Of The Observatory.