At the age of twelve, Tygo was seen on television for the first time in a promotion video to get the Olympic Games to the Netherlands. His role in the youth series Fort Alpha (1996) made him famous in the Netherlands. After that, many guest appearances followed, as well as leading parts in television series like De garage (2000), Van Speijk (2006) and Schnitzelparadijs - De serie (2008). Tygo starred in feature films Wasted! (1996), De dominee (2004), A Thousand Kisses (2006) and Dunya & Desie (2008). For his leading role in the feature film Godforsaken (2003), Tygo was granted with a Golden Calf (the Dutch Oscars) for Best Actor in 2003. In 2005 he won a Golden Calf for his role in the feature film Het schnitzelparadijs (2005), but this time he shared the award with his four co-stars.

On stage, he is starring the leading role in the successful theatre production RAAF (2009).

Tygo is a professional voice actor, giving sound to many Disney animation characters.