Stanley Sheff's first feature film, Sinister Flesh (1976), was a black-and-white horror spoof that received critical acclaim among horror and science fiction fans. Sheff and writing partner Bob Greenberg wrote their first screenplay, Revenge Of The Saucermen, which sold to American-International Pictures.

Soon Sheff ventured into network television. He directed/edited an NBC-TV special, "TV - The Fabulous Fifties" with Lucille Ball, Red Skelton, Dinah Shore, Mary Martin, Michael Landon and David Janssen, Hollywood Out-Takes (1978) with George Burns, Amos 'n' Andy: Anatomy of a Controversy (1983), Motown Returns to the Apollo (1985) (Emmy winner for editing), a Chevy Chase "On Location" comedy special for HBO and a one-hour interview with Vincent Price, _Vincent Price: The Sinister Image (1987)_ that aired on the A&E Network as part of the Biography (1987) series. He has also worked for Antenne 2 French Television, directing and editing documentaries.

Sheff founded a video post-production company in Hollywood, where he was soon to meet 'Orson Welles (I)'. Sheff worked exclusively for Welles on his last completed work The Orson Welles Show (1979), with Burt Reynolds, Angie Dickinson and The Muppets. Welles inspired the title for the screenplay Lobster Man from Mars (1989), written by Greenberg and Sheff, with Sheff directing this science-fiction comedy tale of a voracious flesh-eating crustacean from Mars that starred Tony Curtis, Billy Barty and Patrick Macnee. The film had its world premiere at the Sundance Film Festival.

Motion pictures and television are not the only area of interest for Stanley Sheff. He produced, directed and performed a popular comedy radio show that aired on KROQ-FM Los Angeles called "The Young Marquis And Stanley".

Sheff has also applied his talents to directing and performing for the stage. This work includes the comedy improvisational group The Plush Life Players in The Plush Life, a sitcom serial soap opera, and as Professor Klystron in Queen Of Outer Space: The Musical. Other stage shows directed by Sheff include Dancing Cavalcade - Swing of the 1920s and 1930s, Vaudeville Comes Home, The Black Pirate Musical Spectacular and Broadway Confidential for the Los Angeles Conservancy. These stage productions were performed before sold out audiences of over two thousand at the historic Orpheum Theater in downtown Los Angeles.

Sheff resides in Los Angeles where he continues to write, produce and direct feature motion pictures.