Tisca is known for carefully choosing to be part of stories that needed to be brought to the people. With the burning desire to act, every endeavor of hers has been respected and applauded. Tisca has acted in over 50 feature films in different languages with many eminent directors like Aamir Khan, Prakash Jha, Sudhir Mishra, Abhinay Deo and others.

As someone who's always refused to settle for the mediocre, Tisca's persistence and passion not only won her acclaim and fame, but also two Filmfare Awards for a film she wrote, produced and starred in, called "Chutney". Taare Zameen Par, one of her sterling performances, was Indian cinema's official entry to the League of Academy Awards. Another film where Tisca played a refugee, "Qissa", premiered at the Toronto Film Festival (TIFF) in 2013 and was featured in over 20 festivals.

Tisca was nominated at the New York Indian Film Festival in the Best Actress category for her work in '10Ml Love', a film based on "A Midsummer Night's Dream". Her intense performance in the Indian adaptation of the American series "24" was much lauded and made her a household name. "Hostages", her debut on the web, proved to be a runaway hit, endearing her even more to the audiences. "Good Newwz", where she played a key role as a doctor, was also one of the biggest hits of 2020.

Tisca also starred in the Pulitzer-winning play "Dinner with Friends", which deals with the state of the modern marriage. She's been on the jury of the prestigious MAMI Film Festival. Adding another feather to her illustrious hat, Tisca herself created a path to showcase the idea of rising above barriers through filmmaking. Each of her short films have been about breaking barriers: "Chutney" breaks the 'thought barriers' where youth and beauty are prime parameters of how women are perceived; "Chhuri" breaks barriers about preconceived notions of what an Indian housewife should be like; "Socha Na Tha", was a film made at the time when everyone was getting depressed and didn't know how to go about filming (Tisca created this last film by breaking barriers, directing it over the phone and creating it when everyone was in lockdown); "Rubaru", a short that she co-wrote, directed, acted in and produced, was set for release in November 2020.

Beyond her acting career, Tisca has worked with Sam Pitroda on the National Knowledge Commission, to help revamp the Education system. She works consistently with NGOs and small business to give a leg up to entrepreneurs. She authored a book called 'Acting Smart', which talks about the ingredients needed to make a successful career as an actor.