In one episode, Ted Knight wore a sweatshirt with the name and logo of an actual university on it. Soon, college and university students who were fans of the show began sending logo sweatshirts for Knight to wear on the air. From then on, Knight began wearing as many different sweatshirts as possible in each episode to please the fans.

The first university sweatshirt that Ted Knight wore on the show was University of Michigan.

The show was an American adaptation of Brian Cooke's British TV sitcom Keep It in the Family (1980). Another of his successful transatlantic adaptations was the UK show Man About the House (1973) becoming the US show Three's Company (1976).

Monroe was only intended for one episode, but became popular enough to be brought back for more, and eventually became a regular character on the series.

In an infamous episode on this show Monroe gets raped by two women. An article in AV Club describes this in detail:' "For Every Man, There's Two Women" was shot as part of Too Close For Comfort's fourth season, in 1984, though it didn't air until July 20, 1985. The episode gets right down to business. Henry, Muriel, Jackie, and Sara worry when they get a call from Monroe's boss, saying that he didn't show up for his shift as a security guard at the mall. Just then Monroe stumbles through the front door, disheveled, and tells Henry that he'd been kidnapped. Henry assumes Monroe was snatched by a gang of brawny men, but Monroe abashedly says that he was nabbed by two women. [Laughs.] "The little one" drove the van while "the big one" sat on him. [Laughs.] They demanded he cooperate, and Monroe "cooperated all night." [Laughs.] Jackie and Sara are confused by what this could mean, but Henry explains that these women desired Monroe and... "helped themselves." [Laughs.] While Monroe goes upstairs to clean up and change into his high-waisted, neatly pressed blue jeans, Henry argues with his wife and daughters, who don't think a man can be raped, per se, given the physiological response required for a man to have sex. (Apparently these women are unaware of any kind of intercourse in which an erection isn't involved.) As for Monroe, he'd rather forget the whole thing. He doesn't want to call the cops. He's "intimidated by justice" because of what happens to rape victims on TV movies. Henry says he shouldn't watch those kinds of movies, but Monroe says, "That's the only kind they make!" [Laughs.] Henry insists on calling the police, and when the detective arrives, Monroe complains that the women "broke his beeper" [Laughs.] and that while his assailants did remove his blindfold, once he got a look at them he asked for the blindfold back. [Laughs.] He also says that the women threw him into a bathtub full of Jell-O, which the detective says isn't that uncommon ("some of the real sickos go for shredded wheat"). Ultimately, the detective recommends that Monroe forget about pressing charges, since there's no way a court of law would believe that he wasn't a willing participant. Exploring rape in sitcoms was not new territory at this point; shows like "All in the Family," "One Day at a Time" and "The Facts of Life" had already gone there. And showing a man being victimized by females has been showcased on shows like "Law and Order: SVU." But having one of the leads on a sitcom raped by female characters was unique; this might be the only time in television history this ever happened.