The studio initially suggested to the producers that John Denver reprise his role as Jerry Landers from the first film continuing the original's story, but the suggestion was ignored, as producers thought it would be funnier and more original if the sequel contained entirely different characters. With the exception of George Burns in the title role, none of the original film's characters appear in this movie or "Oh, God! You Devil" (1984).

When Tracy and her father are riding to the restaurant in his Jeep, they are not wearing seat belts. This is obvious when Tracey kisses her father on the cheek. In 1980, there were no mandatory seat-belt laws. The first mandatory seat-belt law was enacted in New York State in 1984.

At least three scenes appear in the commercial broadcast TV version that do not appear on the DVD or premium cable channel versions: 1) Tracy buys an ice cream cone from God, who is working as an ice-cream vendor in a park. 2) In the sequence of Tracy looking for God, she sees an ice cream vendor whom she mistakes for God, and the man asks her what flavor she wants. 3) Some dialogue between Tracy and God in which they discuss having a "business lunch". The first scene is referred to by Dr. Newall when he is discussing Tracy with her parents, and then later by Tracy herself at her hearing. The third scene is indirectly referenced by Tracy's father telling her that if he were to "sell the high qualities of a person, he would take that person to lunch."

Featured in Sneak Previews: In God We Trust, Coast to Coast, Somewhere in Time, Stardust Memories, Oh God! Book II (1980)