The filming of the alley scene was very troublesome for the filmmakers, due to the rough neighborhood. The alley was littered with garbage, most of which was used in the film, and plagued with large rats. Local residents angered by the noise created by the film crew would throw bottles and paper bags filled with feces from windows at the crew in the alley below. Worst of all, the film crew found a dead body hidden among the garbage. "The most horrible places I've ever had to film in were the alleys in downtown Los Angeles," Shane Mahan commented, "and Predator 2 was shot in a lot of those disgusting alleys. They were dirty and depressing and gross, with people peeing on walls. We'd be rigging something, and there would be rats there."

When the Predator regains consciousness at the slaughter house resuming his chase after Harrigan, he sees Harrigan in infrared scope, a major bloop, as the Predator didn't put his mask back on. Anyone who watched the 1st installment must remember: without the mask the Predator can only see in red, with only minor distinctions (i.e. hand-to-hand combat with Schwarzenegger). The Predator didn't put his mask back on all throughout till the very end, occasionally using his respirator seen on the rooftop sequence etc. Inside the Predator's spaceship, again, he sees Harrigan down on the floor in infrared.

The Australian Special Edition DVD released in 2005 is rated MA, but is uncut like the previous R rated version. It is not to be confused with the cut M rated version available on video.

Featured in Siskel & Ebert: 3 Men and a Little Lady/The Nutcracker Prince/Predator 2/Mr. And Mrs. Bridge (1990)