The vanity card at the end of the first episode (the producer has added a long text, visible for only a second, at the end of every episode, called a "vanity card") starts with "Thank you for videotaping "Dharma & Greg" and freeze-framing on my vanity card." Near the end, it says, "I believe that when ABC reads this, I'm gonna be in biiiig trouble."

Not only did the producer add a vanity card at the end of episode one, but at the end of every episode (visible for about two seconds, readable when freeze-framed). The main text included various "beliefs" of the producer, as well as various outlooks on life. One in particular simply read, "All work and no play makes Chuck a dull boy" over and over, except for the very middle of the screen, where it says, "If you have stuck with this and read this far you are an exceptional person." Another said, "the meaning of life might be "Sit, UBU, sit."

In a rarity for a series that ran 5 full seasons, all the principal characters (Darma, Greg & both sets of parents) appear in all 119 episodes.

Jenna Elfman's real-life husband Bodhi Elfman appeared in 2.6: A Closet Full of Hell and 3.11: Lawyers, Beer and Money, and as performance artist "Terry" in episode 5.8, "Home Is Where the Art Is".

As of 2019, only seasons one and two are available on DVD while the other seasons have yet to be released.