Bob and Margaret was the second adult animated series after Family Dog (a failed CBS sitcom) to be produced by Nelvana, who originally had made their name in children's properties, such as Grossology, Stickin' Around, Maggie and the Ferocious Beast, and Eek! The Cat. The series also served as Nelvana's first adult animated project since 1983's Rock & Rule. Most of the production was done in the Toronto-based Nelvana studio, including people who worked on other Nelvana shows, such as Clone High, The Magic School Bus, and Tales from the Cryptkeeper, with the character design supervisor being Todd Kauffman, who would later be well-known for his work on shows like 6teen, Yin Yang Yo!, and Total Drama, and would later be known for creating Sidekick, Grojband, and Looped. Sound editor Ryan Araki would later do audio work for The Bob's Burgers Movie.
