Director John Fawcett refused to have CGI effects in the film, opting for all of the special creature effects to be done with prosthetics and makeup.

Along with the coincidence of stars Katharine Isabelle and Emily Perkins auditioning on the same day, the two actresses were also born in the same hospital, attended the same preschool, elementary school, and private school, and worked through the same talent agency.

Despite major success internationally in The UK and Australia, "Ginger Snaps" struggled to get noticed in the USA until HBO began airing it in the early 2000's, which was when the film started to pique the interest of North American Horror fans.

Katharine Isabelle's monster makeup would take three hours to apply and an additional 45 minutes to remove after shooting.

Due to the fact that the film features teenagers in violent situations the production had difficulty getting funding because the Columbine massacre and other school shootings had recently occurred.