- Alice: [from trailer] We fought the infection. We survived the apocalypse. And now, we face extinction.
- Chase: Climb the Eiffel Tower with a high-powered rifle. A few years ago, that would've caused a stir. Well... Let the good times roll!
- [last lines]
- Alice: You won't have to wait that long, boys. Because I'm coming for you. And I'm gonna be bringing a few of my friends.
- Dr. Isaacs: [as the Tyrant] For so long, I thought you were the future; I was wrong. I am the future.
- Alice: [laughs] No. You're just another asshole, and we're both gonna die down here.
- [laser grid turns on and slices the Tyrant into pieces]
- [narration beginning at title sequence]
- Alice: The Umbrella Corporation thought they'd contained the infection. Well, they were wrong. Raccoon City was just the beginning. Within weeks, the T-virus had consumed the United States. Within months, the world. The virus didn't just wipe out human life. Lakes and rivers dried up, forests became deserts and whole continents were reduced to nothing more than barren wastelands. Slowly but surely, the Earth began to wither and die. What few survivors there were learned to keep on the move. We avoided major cities. If we stopped anyplace too long, they would be drawn to us. Only a few at first, but then more and more. A never-ending army of undead. For those of us left, staying on the road seemed the only way to stay alive.
- Slater: [upon seeing 5 to 6 empty anti-virus vials that Isaacs had injected himself with] How much of this have you used?
- Dr. Isaacs: [while injecting himself with the anti-virus] Her blood increased the creatures' power. It also increased the strength of the infection. I needed it.
- Slater: You have no idea what this will do to you.
- Dr. Isaacs: [sarcastically] Oh, I have an idea.
- Slater: You're out of control. Well, this ends here. Under Executive Order 1345, issued by Chairman Wesker for insubordination and gross misconduct in the field, I sentence you to summary liquidation.
- Dr. Isaacs: Liquidation?
- Slater: [before shooting Isaacs in the heart with his handgun] No, just die.
- [after finding a joint tucked away in the crashed oil truck]
- Carlos Olivera: Well, I'll be damned, L.J., you sneaky son of a bitch.
- White Queen: I'm sorry, I didn't mean to startle you. I am the artificial intelligence which...
- Alice: Yeah, I know what you are. I knew your sister. She was a homicidal bitch.
- White Queen: My sister computer was merely following the most logical path of preservation of human life.
- Alice: Yeah. Kill a few, save a lot.
- [Dr. Issacs, in Tyrant form, has been sliced by the laser grid and a clone of Alice reacts to Issacs explaining to the real Alice that he is the future as the Alice clone deactivates the grid]
- Alice: [watching as Issacs is sliced into bits and falls to the floor] Yeah, you're the future all right!
- L.J.: [he and Carlos have entered an abandoned motel] I'm gonna get me a room. I'll take a waterbed, a jacuzzi, and I'm gonna rent me a porno.
- Albert Wesker: [to Dr. Isaacs] Continue with your research, Doctor... while is is still *your* research.
- Dr. Isaacs: When she's dead make sure you move in fast. I want a sample of her blood while it's still warm.
- Lab Tech: That won't be a problem.
- Betty: [nursing L.J.'s wounds] You like playing rough, huh?
- L.J.: Oh, I've had worse.
- Betty: I'm sure.
- L.J.: But you've always been gentle with me, Betty.
- Carlos Olivera: Oh, God. I'm leaving.
- Dr. Isaacs: For so long, I thought you were the future. I was wrong. I am the future.
- Alice: No. You're just... another asshole.