Originally, Kevin Smith announced in 2017 that Clerks 3 was off the table after a falling-out with his friend Jeff Anderson who had played Randal Graves in Clerks (1994) and Clerks II (2006). Anderson had read the script but chose not to be involved; Smith canceled the project and made Jay and Silent Bob Reboot (2019) instead. Two weeks before Jay and Silent Bob Reboot was released, however, Smith revealed that he had spent an entire day signing Clerks movie memorabilia together with Anderson and Jason Mewes (Jay). This reunion allowed them to patch things up, and provided him with so much inspiration that he immediately threw away the old script, and started working on a new one with ideas that Anderson was receptive to. According to Smith, it will be "a movie that concludes a saga [...] about how you're never too old to completely change your life [...] about how a decades-spanning friendship finally confronts the future."

In one scene Jay says that he and Silent Bob watched a movie by holding the tape up to the light. Cassette tape doesn't work like film. Holding the tape up to the light wouldn't show anything.

During the last 3 1/2 minutes of credits, Kevin Smith is heard thanking the viewer for 'coming back to the store a third time' & reading an alternate voiceover ending written for the film.

The UK release was cut, this film had a compulsory cut made. A cut was required to remove a misleading non-BBFC rating symbol, in order to obtain a 15 classification. Cut made in accordance with BBFC policy. An uncut classification was not available.

Featured in Half in the Bag: 2022 Catch-up Part 2 (2023)