Mary Ann (Laura Linney) returns to present-day San Francisco and is reunited with her adopted daughter Shawna (Ellen Page) and ex-husband Brian (Paul Gross), twenty years after leaving them behind to pursue her career. Fleeing the midlife crisis that her picture-perfect Connecticut life created, Mary Ann is quickly drawn back into the orbit of Anna Madrigal (Olympia Dukakis), her chosen family and a new generation of queer young residents living at 28 Barbary Lane.