Delphinapterus leucas (beluga whale): 111179235 Help Entry 111179235         CDS       T05885                                  Symbol PIK3CB Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism dle  Delphinapterus leucas (beluga whale) Pathway dle00562   Inositol phosphate metabolism dle01100   Metabolic pathways dle01521   EGFR tyrosine kinase inhibitor resistance dle01522   Endocrine resistance dle01524   Platinum drug resistance dle04012   ErbB signaling pathway dle04014   Ras signaling pathway dle04015   Rap1 signaling pathway dle04024   cAMP signaling pathway dle04062   Chemokine signaling pathway dle04066   HIF-1 signaling pathway dle04068   FoxO signaling pathway dle04070   Phosphatidylinositol signaling system dle04071   Sphingolipid signaling pathway dle04072   Phospholipase D signaling pathway dle04081   Hormone signaling dle04140   Autophagy - animal dle04150   mTOR signaling pathway dle04151   PI3K-Akt signaling pathway dle04152   AMPK signaling pathway dle04210   Apoptosis dle04211   Longevity regulating pathway dle04213   Longevity regulating pathway - multiple species dle04218   Cellular senescence dle04360   Axon guidance dle04370   VEGF signaling pathway dle04380   Osteoclast differentiation dle04510   Focal adhesion dle04550   Signaling pathways regulating pluripotency of stem cells dle04611   Platelet activation dle04613   Neutrophil extracellular trap formation dle04620   Toll-like receptor signaling pathway dle04625   C-type lectin receptor signaling pathway dle04630   JAK-STAT signaling pathway dle04650   Natural killer cell mediated cytotoxicity dle04660   T cell receptor signaling pathway dle04662   B cell receptor signaling pathway dle04664   Fc epsilon RI signaling pathway dle04666   Fc gamma R-mediated phagocytosis dle04668   TNF signaling pathway dle04670   Leukocyte transendothelial migration dle04722   Neurotrophin signaling pathway dle04725   Cholinergic synapse dle04750   Inflammatory mediator regulation of TRP channels dle04810   Regulation of actin cytoskeleton dle04910   Insulin signaling pathway dle04914   Progesterone-mediated oocyte maturation dle04915   Estrogen signaling pathway dle04917   Prolactin signaling pathway dle04919   Thyroid hormone signaling pathway dle04923   Regulation of lipolysis in adipocytes dle04926   Relaxin signaling pathway dle04929   GnRH secretion dle04930   Type II diabetes mellitus dle04931   Insulin resistance dle04932   Non-alcoholic fatty liver disease dle04933   AGE-RAGE signaling pathway in diabetic complications dle04935   Growth hormone synthesis, secretion and action dle04960   Aldosterone-regulated sodium reabsorption dle04973   Carbohydrate digestion and absorption dle05010   Alzheimer disease dle05017   Spinocerebellar ataxia dle05020   Prion disease dle05100   Bacterial invasion of epithelial cells dle05132   Salmonella infection dle05135   Yersinia infection dle05142   Chagas disease dle05146   Amoebiasis dle05160   Hepatitis C dle05161   Hepatitis B dle05162   Measles dle05163   Human cytomegalovirus infection dle05164   Influenza A dle05165   Human papillomavirus infection dle05166   Human T-cell leukemia virus 1 infection dle05167   Kaposi sarcoma-associated herpesvirus infection dle05168   Herpes simplex virus 1 infection dle05169   Epstein-Barr virus infection dle05170   Human immunodeficiency virus 1 infection dle05171   Coronavirus disease - COVID-19 dle05200   Pathways in cancer dle05203   Viral carcinogenesis dle05205   Proteoglycans in cancer dle05206   MicroRNAs in cancer dle05207   Chemical carcinogenesis - receptor activation dle05208   Chemical carcinogenesis - reactive oxygen species dle05210   Colorectal cancer dle05211   Renal cell carcinoma dle05212   Pancreatic cancer dle05213   Endometrial cancer dle05214   Glioma dle05215   Prostate cancer dle05218   Melanoma dle05220   Chronic myeloid leukemia dle05221   Acute myeloid leukemia dle05222   Small cell lung cancer dle05223   Non-small cell lung cancer dle05224   Breast cancer dle05225   Hepatocellular carcinoma dle05226   Gastric cancer dle05230   Central carbon metabolism in cancer dle05231   Choline metabolism in cancer dle05235   PD-L1 expression and PD-1 checkpoint pathway in cancer dle05415   Diabetic cardiomyopathy dle05417   Lipid and atherosclerosis dle05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:dle00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     111179235 (PIK3CB)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     111179235 (PIK3CB)    04015 Rap1 signaling pathway     111179235 (PIK3CB)    04630 JAK-STAT signaling pathway     111179235 (PIK3CB)    04668 TNF signaling pathway     111179235 (PIK3CB)    04066 HIF-1 signaling pathway     111179235 (PIK3CB)    04068 FoxO signaling pathway     111179235 (PIK3CB)    04070 Phosphatidylinositol signaling system     111179235 (PIK3CB)    04072 Phospholipase D signaling pathway     111179235 (PIK3CB)    04071 Sphingolipid signaling pathway     111179235 (PIK3CB)    04024 cAMP signaling pathway     111179235 (PIK3CB)    04151 PI3K-Akt signaling pathway     111179235 (PIK3CB)    04152 AMPK signaling pathway     111179235 (PIK3CB)    04150 mTOR signaling pathway     111179235 (PIK3CB)   09133 Signaling molecules and interaction    04081 Hormone signaling     111179235 (PIK3CB)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     111179235 (PIK3CB)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     111179235 (PIK3CB)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     111179235 (PIK3CB)    04613 Neutrophil extracellular trap formation     111179235 (PIK3CB)    04620 Toll-like receptor signaling pathway     111179235 (PIK3CB)    04650 Natural killer cell mediated cytotoxicity     111179235 (PIK3CB)    04660 T cell receptor signaling pathway     111179235 (PIK3CB)    04662 B cell receptor signaling pathway     111179235 (PIK3CB)    04664 Fc epsilon RI signaling pathway     111179235 (PIK3CB)    04666 Fc gamma R-mediated phagocytosis     111179235 (PIK3CB)    04670 Leukocyte transendothelial migration     111179235 (PIK3CB)    04062 Chemokine signaling pathway     111179235 (PIK3CB)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     111179235 (PIK3CB)    04929 GnRH secretion     111179235 (PIK3CB)    04915 Estrogen signaling pathway     111179235 (PIK3CB)    04917 Prolactin signaling pathway     111179235 (PIK3CB)    04926 Relaxin signaling pathway     111179235 (PIK3CB)    04935 Growth hormone synthesis, secretion and action     111179235 (PIK3CB)    04919 Thyroid hormone signaling pathway     111179235 (PIK3CB)   09154 Digestive system    04973 Carbohydrate digestion and absorption     111179235 (PIK3CB)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     111179235 (PIK3CB)   09156 Nervous system    04725 Cholinergic synapse     111179235 (PIK3CB)    04722 Neurotrophin signaling pathway     111179235 (PIK3CB)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     111179235 (PIK3CB)   09158 Development and regeneration    04360 Axon guidance     111179235 (PIK3CB)    04380 Osteoclast differentiation     111179235 (PIK3CB)   09149 Aging    04211 Longevity regulating pathway     111179235 (PIK3CB)    04213 Longevity regulating pathway - multiple species     111179235 (PIK3CB)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     111179235 (PIK3CB)    05206 MicroRNAs in cancer     111179235 (PIK3CB)    05205 Proteoglycans in cancer     111179235 (PIK3CB)    05207 Chemical carcinogenesis - receptor activation     111179235 (PIK3CB)    05208 Chemical carcinogenesis - reactive oxygen species     111179235 (PIK3CB)    05203 Viral carcinogenesis     111179235 (PIK3CB)    05230 Central carbon metabolism in cancer     111179235 (PIK3CB)    05231 Choline metabolism in cancer     111179235 (PIK3CB)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     111179235 (PIK3CB)   09162 Cancer: specific types    05210 Colorectal cancer     111179235 (PIK3CB)    05212 Pancreatic cancer     111179235 (PIK3CB)    05225 Hepatocellular carcinoma     111179235 (PIK3CB)    05226 Gastric cancer     111179235 (PIK3CB)    05214 Glioma     111179235 (PIK3CB)    05221 Acute myeloid leukemia     111179235 (PIK3CB)    05220 Chronic myeloid leukemia     111179235 (PIK3CB)    05218 Melanoma     111179235 (PIK3CB)    05211 Renal cell carcinoma     111179235 (PIK3CB)    05215 Prostate cancer     111179235 (PIK3CB)    05213 Endometrial cancer     111179235 (PIK3CB)    05224 Breast cancer     111179235 (PIK3CB)    05222 Small cell lung cancer     111179235 (PIK3CB)    05223 Non-small cell lung cancer     111179235 (PIK3CB)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     111179235 (PIK3CB)    05170 Human immunodeficiency virus 1 infection     111179235 (PIK3CB)    05161 Hepatitis B     111179235 (PIK3CB)    05160 Hepatitis C     111179235 (PIK3CB)    05171 Coronavirus disease - COVID-19     111179235 (PIK3CB)    05164 Influenza A     111179235 (PIK3CB)    05162 Measles     111179235 (PIK3CB)    05163 Human cytomegalovirus infection     111179235 (PIK3CB)    05167 Kaposi sarcoma-associated herpesvirus infection     111179235 (PIK3CB)    05169 Epstein-Barr virus infection     111179235 (PIK3CB)    05165 Human papillomavirus infection     111179235 (PIK3CB)   09171 Infectious disease: bacterial    05135 Yersinia infection     111179235 (PIK3CB)    05100 Bacterial invasion of epithelial cells     111179235 (PIK3CB)   09174 Infectious disease: parasitic    05146 Amoebiasis     111179235 (PIK3CB)    05142 Chagas disease     111179235 (PIK3CB)   09164 Neurodegenerative disease    05010 Alzheimer disease     111179235 (PIK3CB)    05017 Spinocerebellar ataxia     111179235 (PIK3CB)    05020 Prion disease     111179235 (PIK3CB)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     111179235 (PIK3CB)    05418 Fluid shear stress and atherosclerosis     111179235 (PIK3CB)    05415 Diabetic cardiomyopathy     111179235 (PIK3CB)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     111179235 (PIK3CB)    04932 Non-alcoholic fatty liver disease     111179235 (PIK3CB)    04931 Insulin resistance     111179235 (PIK3CB)    04933 AGE-RAGE signaling pathway in diabetic complications     111179235 (PIK3CB)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     111179235 (PIK3CB)    01524 Platinum drug resistance     111179235 (PIK3CB)    01522 Endocrine resistance     111179235 (PIK3CB)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:dle04131]     111179235 (PIK3CB) Enzymes [BR:dle01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      111179235 (PIK3CB) Membrane trafficking [BR:dle04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     111179235 (PIK3CB) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C Motif Other DBs NCBI-GeneID:  111179235 NCBI-ProteinID:  XP_022438316 UniProt:  A0A2Y9NZC3 LinkDB All DBs Position Unknown AA seq 1064 aa AA seqDB search MPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLWKQVHNY PMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGEKLDSKI GVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKQTYPPEHEPSIPE NLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHGKEDEVSPYDY VLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMIAIEAAINR NSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCK TVVSSEISGKNDHIWNEPLEFDISTCDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQ TIRKSGKVDYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQTNPYTE NATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKEILDRDP LSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKLPPREA LELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALA NRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLKTLNSLI KLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYIEKCKYMDSKMKPL WLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGD HSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEEFTLSCA GYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFILTYDFIH VIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKDIQYLKD SLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS NT seq 3195 nt NT seq  +upstreamnt  +downstreamnt atgcctcctgctatggcagacatccttgacatctgggcagtggattcacagatagcatct gatggctccatacctgtggatttccttttgcccactgggatttatatccagttggaggta cctcgggaagctaccatttcctatattaaacagatgttatggaaacaagttcataattac ccaatgtttaacctccttatggaaattgactcctatatgtttgcatgtgtgaatcaaact gctgtatatgaggagcttgaagatgaaacaagaagactctgtgatgtcagaccttttctt ccagttctcaaattagtgacaagaagttgtgacccaggggaaaaattagactcaaaaatt ggagtccttataggaagaggtttgcatgaatttgatgccttgaaggatcctgaggtgaat gaattccgaataaaaatgcgcagattcagtgaggaaaagattcagtcgcttgtgggattg tcttggatggattggctaaagcaaacctatccaccagagcatgaaccatccattcctgaa aatttagaagataaactttacggaggaaagctcattgtggctgttcattttgaaaattgt caggatgtgtttagctttcaagtatctcctaatatgaatcctatcaaaataaatgaattg gcaatccaaaaacgtttgactattcatgggaaagaagatgaagttagcccctatgactat gtgttgcaagtcagtgggagagtagaatatgtgtttggtgatcacccactaattcagttc cagtatatccggaactgtgtaatgaataggaccttgccccattttatacttgtggaatgt tgcaagatcaagaagctgtatgaacaggaaatgattgccatagaggctgccataaatcga aattcatctaaccttcctcttcctttaccaccaaagaaaactcgaattatttctcatgtt tgggaaaataacaaccctttccaaattgtcttggttaagggaaataaacttaacacagaa gaaactgtaaaagttcatgtcagggctggcctttttcatggtaccgaactcctgtgtaaa accgtcgtaagctcagagatatcagggaaaaacgatcatatttggaatgaaccactggaa tttgatatcagtacttgtgacctgccacgaatggctcgattatgtttcgctgtttatgca gttttggataaagtgaaaacgaagaaatcaactaaaactattaatccctctaaatatcag accatcaggaaatctggaaaagtggattatcctgtagcctgggtaaatacgatggttttt gactttaaaggacagttgagatctggagatataatattgcacagctggtcttcatttcct gatgaacttgaagaaatgttgaatccaatgggaactgttcaaacaaatccatatactgaa aatgcaacagctttgcacatcagattcccagagaataaaaaacaaccttattactatcct ccctttgataagattattgaaaaggcagctgagattgcaagcagtgatagtgctaatgta tcaagtcgaggtggaaagaagtttcttgctgtactgaaagaaatcttggacagggatccg ttgtctcaactgtgtgagaatgaaatggatcttatttggactttgcgacaagactgcaga gagaatttcccacagtcattgccaaaattactgctgtcaatcaagtggaataaacttgag gatgttgctcagcttcaggcactacttcagatttggcctaaactgcccccccgggaggcc ctggagcttctagatttcaactatccagatcagtacgtgcgagaatatgctgtgggctgt ctgcaacagatgagtgatgaagaactctctcagtatcttttacagttggtgcaagtttta aaatatgagccttttcttgattgtgccctctctagattcctactagaaagagcacttgct aatcggaggatagggcagtttttattttggcaccttaggtcagaagtgcacattcctgct gtttcagtacaatttggtgtcatccttgaagcatactgccggggaagcgtaggtcacatg aaagcgctttccaagcaggttgaagcactcaataagttaaaaactttaaatagtttaatc aaactgaatgcaatgaagctaaatagagccaaagggaaagaagcaatgcacacttgttta aaacagaatgcttatcgggaagccctctctgacctgcaatcacctctgaacccatgtgtt atcctctcagaactctatattgaaaagtgtaaatacatggattccaaaatgaagcctttg tggctggtgtacaacaacaaggtgtttggtgaggattcagttggagtgatttttaaaaat ggtgatgatttacggcaggatatgttgacactccaaatgctgcgcttgatggatttactc tggaaagaagctggtctggatcttaggatgctgccttatggctgtttagcaacaggagac cactctggcctcattgaagttgtgagcacctctgaaacaattgctgacattcagctgaac agtagcaatgtggctgcagcagcagccttcaacaaagatgcccttctgaactggcttaaa gaatacaattctggggatgacctggaccgagccattgaggagtttaccctgtcctgtgcc ggctactgtgtagcttcttatgtccttgggattggtgacagacatagtgataacatcatg gtcaaaaaaactggccagctcttccacattgactttggacatattcttggaaatttcaag tctaaatttggcattaaaagggagagagtgccttttattcttacctatgatttcattcat gtgattcaacaaggaaaaacaggaaacacggaaaagtttggccggttccgccagtgttgt gaggatgcatatctgattttacgacggcatgggaatctcttcatcactctctttgcactg atgttgactgcagggcttcctgagctcacatcagtcaaggatatacagtatcttaaggac tctcttgccttagggaagagtgaagaagaagcactcaagcaatttaagcaaaaatttgat gaggcactcagggaaagctggactactaaagtgaactggatggcccacacagttcggaaa gactacagatcttaa

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