Equus asinus (ass): 106838100 Help Entry 106838100         CDS       T04645                                  Symbol PIK3CB Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism eai  Equus asinus (ass) Pathway eai00562   Inositol phosphate metabolism eai01100   Metabolic pathways eai01521   EGFR tyrosine kinase inhibitor resistance eai01522   Endocrine resistance eai01524   Platinum drug resistance eai04012   ErbB signaling pathway eai04014   Ras signaling pathway eai04015   Rap1 signaling pathway eai04024   cAMP signaling pathway eai04062   Chemokine signaling pathway eai04066   HIF-1 signaling pathway eai04068   FoxO signaling pathway eai04070   Phosphatidylinositol signaling system eai04071   Sphingolipid signaling pathway eai04072   Phospholipase D signaling pathway eai04081   Hormone signaling eai04140   Autophagy - animal eai04150   mTOR signaling pathway eai04151   PI3K-Akt signaling pathway eai04152   AMPK signaling pathway eai04210   Apoptosis eai04211   Longevity regulating pathway eai04213   Longevity regulating pathway - multiple species eai04218   Cellular senescence eai04360   Axon guidance eai04370   VEGF signaling pathway eai04380   Osteoclast differentiation eai04510   Focal adhesion eai04550   Signaling pathways regulating pluripotency of stem cells eai04611   Platelet activation eai04613   Neutrophil extracellular trap formation eai04620   Toll-like receptor signaling pathway eai04625   C-type lectin receptor signaling pathway eai04630   JAK-STAT signaling pathway eai04650   Natural killer cell mediated cytotoxicity eai04660   T cell receptor signaling pathway eai04662   B cell receptor signaling pathway eai04664   Fc epsilon RI signaling pathway eai04666   Fc gamma R-mediated phagocytosis eai04668   TNF signaling pathway eai04670   Leukocyte transendothelial migration eai04722   Neurotrophin signaling pathway eai04725   Cholinergic synapse eai04750   Inflammatory mediator regulation of TRP channels eai04810   Regulation of actin cytoskeleton eai04910   Insulin signaling pathway eai04914   Progesterone-mediated oocyte maturation eai04915   Estrogen signaling pathway eai04917   Prolactin signaling pathway eai04919   Thyroid hormone signaling pathway eai04923   Regulation of lipolysis in adipocytes eai04926   Relaxin signaling pathway eai04929   GnRH secretion eai04930   Type II diabetes mellitus eai04931   Insulin resistance eai04932   Non-alcoholic fatty liver disease eai04933   AGE-RAGE signaling pathway in diabetic complications eai04935   Growth hormone synthesis, secretion and action eai04960   Aldosterone-regulated sodium reabsorption eai04973   Carbohydrate digestion and absorption eai05010   Alzheimer disease eai05017   Spinocerebellar ataxia eai05020   Prion disease eai05100   Bacterial invasion of epithelial cells eai05132   Salmonella infection eai05135   Yersinia infection eai05142   Chagas disease eai05146   Amoebiasis eai05160   Hepatitis C eai05161   Hepatitis B eai05162   Measles eai05163   Human cytomegalovirus infection eai05164   Influenza A eai05165   Human papillomavirus infection eai05166   Human T-cell leukemia virus 1 infection eai05167   Kaposi sarcoma-associated herpesvirus infection eai05168   Herpes simplex virus 1 infection eai05169   Epstein-Barr virus infection eai05170   Human immunodeficiency virus 1 infection eai05171   Coronavirus disease - COVID-19 eai05200   Pathways in cancer eai05203   Viral carcinogenesis eai05205   Proteoglycans in cancer eai05206   MicroRNAs in cancer eai05207   Chemical carcinogenesis - receptor activation eai05208   Chemical carcinogenesis - reactive oxygen species eai05210   Colorectal cancer eai05211   Renal cell carcinoma eai05212   Pancreatic cancer eai05213   Endometrial cancer eai05214   Glioma eai05215   Prostate cancer eai05218   Melanoma eai05220   Chronic myeloid leukemia eai05221   Acute myeloid leukemia eai05222   Small cell lung cancer eai05223   Non-small cell lung cancer eai05224   Breast cancer eai05225   Hepatocellular carcinoma eai05226   Gastric cancer eai05230   Central carbon metabolism in cancer eai05231   Choline metabolism in cancer eai05235   PD-L1 expression and PD-1 checkpoint pathway in cancer eai05415   Diabetic cardiomyopathy eai05417   Lipid and atherosclerosis eai05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:eai00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     106838100 (PIK3CB)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     106838100 (PIK3CB)    04015 Rap1 signaling pathway     106838100 (PIK3CB)    04630 JAK-STAT signaling pathway     106838100 (PIK3CB)    04668 TNF signaling pathway     106838100 (PIK3CB)    04066 HIF-1 signaling pathway     106838100 (PIK3CB)    04068 FoxO signaling pathway     106838100 (PIK3CB)    04070 Phosphatidylinositol signaling system     106838100 (PIK3CB)    04072 Phospholipase D signaling pathway     106838100 (PIK3CB)    04071 Sphingolipid signaling pathway     106838100 (PIK3CB)    04024 cAMP signaling pathway     106838100 (PIK3CB)    04151 PI3K-Akt signaling pathway     106838100 (PIK3CB)    04152 AMPK signaling pathway     106838100 (PIK3CB)    04150 mTOR signaling pathway     106838100 (PIK3CB)   09133 Signaling molecules and interaction    04081 Hormone signaling     106838100 (PIK3CB)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     106838100 (PIK3CB)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     106838100 (PIK3CB)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     106838100 (PIK3CB)    04613 Neutrophil extracellular trap formation     106838100 (PIK3CB)    04620 Toll-like receptor signaling pathway     106838100 (PIK3CB)    04650 Natural killer cell mediated cytotoxicity     106838100 (PIK3CB)    04660 T cell receptor signaling pathway     106838100 (PIK3CB)    04662 B cell receptor signaling pathway     106838100 (PIK3CB)    04664 Fc epsilon RI signaling pathway     106838100 (PIK3CB)    04666 Fc gamma R-mediated phagocytosis     106838100 (PIK3CB)    04670 Leukocyte transendothelial migration     106838100 (PIK3CB)    04062 Chemokine signaling pathway     106838100 (PIK3CB)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     106838100 (PIK3CB)    04929 GnRH secretion     106838100 (PIK3CB)    04915 Estrogen signaling pathway     106838100 (PIK3CB)    04917 Prolactin signaling pathway     106838100 (PIK3CB)    04926 Relaxin signaling pathway     106838100 (PIK3CB)    04935 Growth hormone synthesis, secretion and action     106838100 (PIK3CB)    04919 Thyroid hormone signaling pathway     106838100 (PIK3CB)   09154 Digestive system    04973 Carbohydrate digestion and absorption     106838100 (PIK3CB)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     106838100 (PIK3CB)   09156 Nervous system    04725 Cholinergic synapse     106838100 (PIK3CB)    04722 Neurotrophin signaling pathway     106838100 (PIK3CB)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     106838100 (PIK3CB)   09158 Development and regeneration    04360 Axon guidance     106838100 (PIK3CB)    04380 Osteoclast differentiation     106838100 (PIK3CB)   09149 Aging    04211 Longevity regulating pathway     106838100 (PIK3CB)    04213 Longevity regulating pathway - multiple species     106838100 (PIK3CB)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     106838100 (PIK3CB)    05206 MicroRNAs in cancer     106838100 (PIK3CB)    05205 Proteoglycans in cancer     106838100 (PIK3CB)    05207 Chemical carcinogenesis - receptor activation     106838100 (PIK3CB)    05208 Chemical carcinogenesis - reactive oxygen species     106838100 (PIK3CB)    05203 Viral carcinogenesis     106838100 (PIK3CB)    05230 Central carbon metabolism in cancer     106838100 (PIK3CB)    05231 Choline metabolism in cancer     106838100 (PIK3CB)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     106838100 (PIK3CB)   09162 Cancer: specific types    05210 Colorectal cancer     106838100 (PIK3CB)    05212 Pancreatic cancer     106838100 (PIK3CB)    05225 Hepatocellular carcinoma     106838100 (PIK3CB)    05226 Gastric cancer     106838100 (PIK3CB)    05214 Glioma     106838100 (PIK3CB)    05221 Acute myeloid leukemia     106838100 (PIK3CB)    05220 Chronic myeloid leukemia     106838100 (PIK3CB)    05218 Melanoma     106838100 (PIK3CB)    05211 Renal cell carcinoma     106838100 (PIK3CB)    05215 Prostate cancer     106838100 (PIK3CB)    05213 Endometrial cancer     106838100 (PIK3CB)    05224 Breast cancer     106838100 (PIK3CB)    05222 Small cell lung cancer     106838100 (PIK3CB)    05223 Non-small cell lung cancer     106838100 (PIK3CB)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     106838100 (PIK3CB)    05170 Human immunodeficiency virus 1 infection     106838100 (PIK3CB)    05161 Hepatitis B     106838100 (PIK3CB)    05160 Hepatitis C     106838100 (PIK3CB)    05171 Coronavirus disease - COVID-19     106838100 (PIK3CB)    05164 Influenza A     106838100 (PIK3CB)    05162 Measles     106838100 (PIK3CB)    05163 Human cytomegalovirus infection     106838100 (PIK3CB)    05167 Kaposi sarcoma-associated herpesvirus infection     106838100 (PIK3CB)    05169 Epstein-Barr virus infection     106838100 (PIK3CB)    05165 Human papillomavirus infection     106838100 (PIK3CB)   09171 Infectious disease: bacterial    05135 Yersinia infection     106838100 (PIK3CB)    05100 Bacterial invasion of epithelial cells     106838100 (PIK3CB)   09174 Infectious disease: parasitic    05146 Amoebiasis     106838100 (PIK3CB)    05142 Chagas disease     106838100 (PIK3CB)   09164 Neurodegenerative disease    05010 Alzheimer disease     106838100 (PIK3CB)    05017 Spinocerebellar ataxia     106838100 (PIK3CB)    05020 Prion disease     106838100 (PIK3CB)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     106838100 (PIK3CB)    05418 Fluid shear stress and atherosclerosis     106838100 (PIK3CB)    05415 Diabetic cardiomyopathy     106838100 (PIK3CB)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     106838100 (PIK3CB)    04932 Non-alcoholic fatty liver disease     106838100 (PIK3CB)    04931 Insulin resistance     106838100 (PIK3CB)    04933 AGE-RAGE signaling pathway in diabetic complications     106838100 (PIK3CB)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     106838100 (PIK3CB)    01524 Platinum drug resistance     106838100 (PIK3CB)    01522 Endocrine resistance     106838100 (PIK3CB)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:eai04131]     106838100 (PIK3CB) Enzymes [BR:eai01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      106838100 (PIK3CB) Membrane trafficking [BR:eai04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     106838100 (PIK3CB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Motif Other DBs NCBI-GeneID:  106838100 NCBI-ProteinID:  XP_014707486 LinkDB All DBs Position 21:23356121..23525964 Genome browser AA seq 1070 aa AA seqDB search MCFNFMMPPAMADSLDIWSVDSQIVSDGSIRVDFLLPTGIYIQLDVPREAPISYIKQMLW KQVCDYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE KLDSKIGVLIGKGLHEFDALKDPEVNEFRVKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH EPSNLENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIRGKEDE VSPCDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI EAAINRNSSNLPLPLPPKKTRVISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG TELLCKTIVSSEIAGKNDHIWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDVILHSWSSFPDELEEMLNPMGTVQ TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK LPPREALELLDFNYPDQYVREYAVNCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD SKMKPLWLVYTNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt atgtgcttcaacttcatgatgcctcctgctatggcagacagccttgacatctggtcagtg gattcacagatagtatctgatggctccatacgtgtggatttccttttacccactgggatt tatatccagttggacgtacctcgggaagctcccatttcctatattaaacagatgttatgg aagcaagtttgcgattacccaatgtttaaccttcttatggaaattgactcctatatgttt gcatgtgtgaatcaaactgctgtgtatgaggagcttgaagatgaaacaagaagactgtgt gatgtccgaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgatgccttg aaggatcctgaggtgaatgaattccgagtaaaaatgcgaaaattcagtgaggaaaagatt cagtcgcttgtgggattgtcttggatggattggctaaagcagacatatccaccagagcat gaaccctctaaccttgaaaacttagaagataaactttatggaggaaagctcattgtggct gttcattttgaaaattgtcaggatgtgtttagctttcaagtatctcctaatatgaatcct atcaaaataaatgaattggcaatccaaaaacgtttgactattcgtgggaaagaagatgaa gtcagcccttgtgactatgtgctgcaagtcagtgggagagtagaatatgtgtttggtgac cacccattaattcagttccagtatatccggaactgtgtaatgaacaggaccttgccccat tttatacttgtggaatgttgcaagatcaaaaagatgtatgaacaggaaatgattgccata gaggctgccataaatcgaaattcatctaaccttccccttcctttaccaccaaagaaaacg cgagttatttctcacgtttgggaaaataacaaccctttccaaattgtcttggttaaggga aataaacttaacacagaagaaactgtaaaagttcacgtcagagctggcctttttcatggt actgaacttctgtgtaaaaccatcgtaagctcagagatagcagggaaaaatgatcacatt tggaatgaaccactggaatttgatattaatacttgtgacctgccacgaatggctcgatta tgttttgcagtttatgcagttttggataaagtgaaaacaaagaaatcaactaaaactatt aatccctctaaatatcagaccatcaggaaatctgggaaagtgcattatccagtagcatgg gtaaatacgatggtttttgactttaaaggacaattgagatctggagacgtaatattgcac agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa acaaatccatatactgaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa caaccttattattaccctcccttcgataagattatcgaaaaggcagctgagattgcaagc agtgatagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactcaaagaa atcttggacagggatcccttgtctcaactgtgtgagaatgaaatggatcttatttggact ttgagacaagactgcagagagaatttcccacagtcactgccaaaattattgctgtcaatc aagtggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaa ctacccccccgggaggccctggagcttctagatttcaactatccagatcagtacgtgcgg gaatatgctgtgaactgcctgcgacagatgagcgatgaagaactctctcaatatctttta caactggtgcaagttttaaaatacgagccttttttggattgtgccctctctagattccta ttagaaagagcacttgctaatcggaggatagggcagtttctattttggcacctcaggtca gaagtgcacattcctgctgtctctgtgcaatttggtgtcattcttgaagcatactgccgg gggagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataagttaaaa actttaaatagtttaatcaaactgaatgcagtgaagctaaacagagccaaagggaaagag gccatgcacacctgtttaaaacagaatgcttaccgggaggccctctctgacctgcagtca cctctgaacccgtgtgtcatcctctcagaactctatgttgaaaagtgtaaatacatggat tccaaaatgaagcctttgtggctggtgtacaccaacaaggtgtttggggaagattcagtt ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccagatgctg cgcttgatggatttgctctggaaagaagctggtctggatcttcggatgctgccttatggc tgtttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt gctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaataaagatgcc cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaagag tttaccctgtcctgtgccggctactgtgtagcttcttatgtccttggaattggtgacaga catagcgacaacatcatggtcaaaaaaactggccagctcttccacattgactttggacat attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagtttggc cggttccgccaatgttgtgaggatgcgtatctgattttacgacgacatgggaatctcttc atcactctctttgccctgatgttgactgcagggcttcctgagctcacatcagtcaaggat atacagtatcttaaggactctcttgccctagggaagagtgaagaagaagcactcaagcaa tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtaaactggatg gcccacacagtccggaaagactaccgatcttaa

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