Eptesicus fuscus (big brown bat): 103296140 Help Entry 103296140         CDS       T09083                                  Symbol PIK3CB Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism efus  Eptesicus fuscus (big brown bat) Pathway efus00562   Inositol phosphate metabolism efus01100   Metabolic pathways efus01521   EGFR tyrosine kinase inhibitor resistance efus01522   Endocrine resistance efus01524   Platinum drug resistance efus04012   ErbB signaling pathway efus04014   Ras signaling pathway efus04015   Rap1 signaling pathway efus04024   cAMP signaling pathway efus04062   Chemokine signaling pathway efus04066   HIF-1 signaling pathway efus04068   FoxO signaling pathway efus04070   Phosphatidylinositol signaling system efus04071   Sphingolipid signaling pathway efus04072   Phospholipase D signaling pathway efus04081   Hormone signaling efus04140   Autophagy - animal efus04150   mTOR signaling pathway efus04151   PI3K-Akt signaling pathway efus04152   AMPK signaling pathway efus04210   Apoptosis efus04211   Longevity regulating pathway efus04213   Longevity regulating pathway - multiple species efus04218   Cellular senescence efus04360   Axon guidance efus04370   VEGF signaling pathway efus04380   Osteoclast differentiation efus04510   Focal adhesion efus04550   Signaling pathways regulating pluripotency of stem cells efus04611   Platelet activation efus04613   Neutrophil extracellular trap formation efus04620   Toll-like receptor signaling pathway efus04625   C-type lectin receptor signaling pathway efus04630   JAK-STAT signaling pathway efus04650   Natural killer cell mediated cytotoxicity efus04660   T cell receptor signaling pathway efus04662   B cell receptor signaling pathway efus04664   Fc epsilon RI signaling pathway efus04666   Fc gamma R-mediated phagocytosis efus04668   TNF signaling pathway efus04670   Leukocyte transendothelial migration efus04722   Neurotrophin signaling pathway efus04725   Cholinergic synapse efus04750   Inflammatory mediator regulation of TRP channels efus04810   Regulation of actin cytoskeleton efus04910   Insulin signaling pathway efus04914   Progesterone-mediated oocyte maturation efus04915   Estrogen signaling pathway efus04917   Prolactin signaling pathway efus04919   Thyroid hormone signaling pathway efus04923   Regulation of lipolysis in adipocytes efus04926   Relaxin signaling pathway efus04929   GnRH secretion efus04930   Type II diabetes mellitus efus04931   Insulin resistance efus04932   Non-alcoholic fatty liver disease efus04933   AGE-RAGE signaling pathway in diabetic complications efus04935   Growth hormone synthesis, secretion and action efus04960   Aldosterone-regulated sodium reabsorption efus04973   Carbohydrate digestion and absorption efus05010   Alzheimer disease efus05017   Spinocerebellar ataxia efus05020   Prion disease efus05100   Bacterial invasion of epithelial cells efus05132   Salmonella infection efus05135   Yersinia infection efus05142   Chagas disease efus05146   Amoebiasis efus05160   Hepatitis C efus05161   Hepatitis B efus05162   Measles efus05163   Human cytomegalovirus infection efus05164   Influenza A efus05165   Human papillomavirus infection efus05166   Human T-cell leukemia virus 1 infection efus05167   Kaposi sarcoma-associated herpesvirus infection efus05168   Herpes simplex virus 1 infection efus05169   Epstein-Barr virus infection efus05170   Human immunodeficiency virus 1 infection efus05171   Coronavirus disease - COVID-19 efus05200   Pathways in cancer efus05203   Viral carcinogenesis efus05205   Proteoglycans in cancer efus05206   MicroRNAs in cancer efus05207   Chemical carcinogenesis - receptor activation efus05208   Chemical carcinogenesis - reactive oxygen species efus05210   Colorectal cancer efus05211   Renal cell carcinoma efus05212   Pancreatic cancer efus05213   Endometrial cancer efus05214   Glioma efus05215   Prostate cancer efus05218   Melanoma efus05220   Chronic myeloid leukemia efus05221   Acute myeloid leukemia efus05222   Small cell lung cancer efus05223   Non-small cell lung cancer efus05224   Breast cancer efus05225   Hepatocellular carcinoma efus05226   Gastric cancer efus05230   Central carbon metabolism in cancer efus05231   Choline metabolism in cancer efus05235   PD-L1 expression and PD-1 checkpoint pathway in cancer efus05415   Diabetic cardiomyopathy efus05417   Lipid and atherosclerosis efus05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:efus00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103296140 (PIK3CB)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     103296140 (PIK3CB)    04015 Rap1 signaling pathway     103296140 (PIK3CB)    04630 JAK-STAT signaling pathway     103296140 (PIK3CB)    04668 TNF signaling pathway     103296140 (PIK3CB)    04066 HIF-1 signaling pathway     103296140 (PIK3CB)    04068 FoxO signaling pathway     103296140 (PIK3CB)    04070 Phosphatidylinositol signaling system     103296140 (PIK3CB)    04072 Phospholipase D signaling pathway     103296140 (PIK3CB)    04071 Sphingolipid signaling pathway     103296140 (PIK3CB)    04024 cAMP signaling pathway     103296140 (PIK3CB)    04151 PI3K-Akt signaling pathway     103296140 (PIK3CB)    04152 AMPK signaling pathway     103296140 (PIK3CB)    04150 mTOR signaling pathway     103296140 (PIK3CB)   09133 Signaling molecules and interaction    04081 Hormone signaling     103296140 (PIK3CB)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103296140 (PIK3CB)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     103296140 (PIK3CB)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103296140 (PIK3CB)    04613 Neutrophil extracellular trap formation     103296140 (PIK3CB)    04620 Toll-like receptor signaling pathway     103296140 (PIK3CB)    04650 Natural killer cell mediated cytotoxicity     103296140 (PIK3CB)    04660 T cell receptor signaling pathway     103296140 (PIK3CB)    04662 B cell receptor signaling pathway     103296140 (PIK3CB)    04664 Fc epsilon RI signaling pathway     103296140 (PIK3CB)    04666 Fc gamma R-mediated phagocytosis     103296140 (PIK3CB)    04670 Leukocyte transendothelial migration     103296140 (PIK3CB)    04062 Chemokine signaling pathway     103296140 (PIK3CB)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     103296140 (PIK3CB)    04929 GnRH secretion     103296140 (PIK3CB)    04915 Estrogen signaling pathway     103296140 (PIK3CB)    04917 Prolactin signaling pathway     103296140 (PIK3CB)    04926 Relaxin signaling pathway     103296140 (PIK3CB)    04935 Growth hormone synthesis, secretion and action     103296140 (PIK3CB)    04919 Thyroid hormone signaling pathway     103296140 (PIK3CB)   09154 Digestive system    04973 Carbohydrate digestion and absorption     103296140 (PIK3CB)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103296140 (PIK3CB)   09156 Nervous system    04725 Cholinergic synapse     103296140 (PIK3CB)    04722 Neurotrophin signaling pathway     103296140 (PIK3CB)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103296140 (PIK3CB)   09158 Development and regeneration    04360 Axon guidance     103296140 (PIK3CB)    04380 Osteoclast differentiation     103296140 (PIK3CB)   09149 Aging    04211 Longevity regulating pathway     103296140 (PIK3CB)    04213 Longevity regulating pathway - multiple species     103296140 (PIK3CB)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103296140 (PIK3CB)    05206 MicroRNAs in cancer     103296140 (PIK3CB)    05205 Proteoglycans in cancer     103296140 (PIK3CB)    05207 Chemical carcinogenesis - receptor activation     103296140 (PIK3CB)    05208 Chemical carcinogenesis - reactive oxygen species     103296140 (PIK3CB)    05203 Viral carcinogenesis     103296140 (PIK3CB)    05230 Central carbon metabolism in cancer     103296140 (PIK3CB)    05231 Choline metabolism in cancer     103296140 (PIK3CB)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103296140 (PIK3CB)   09162 Cancer: specific types    05210 Colorectal cancer     103296140 (PIK3CB)    05212 Pancreatic cancer     103296140 (PIK3CB)    05225 Hepatocellular carcinoma     103296140 (PIK3CB)    05226 Gastric cancer     103296140 (PIK3CB)    05214 Glioma     103296140 (PIK3CB)    05221 Acute myeloid leukemia     103296140 (PIK3CB)    05220 Chronic myeloid leukemia     103296140 (PIK3CB)    05218 Melanoma     103296140 (PIK3CB)    05211 Renal cell carcinoma     103296140 (PIK3CB)    05215 Prostate cancer     103296140 (PIK3CB)    05213 Endometrial cancer     103296140 (PIK3CB)    05224 Breast cancer     103296140 (PIK3CB)    05222 Small cell lung cancer     103296140 (PIK3CB)    05223 Non-small cell lung cancer     103296140 (PIK3CB)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103296140 (PIK3CB)    05170 Human immunodeficiency virus 1 infection     103296140 (PIK3CB)    05161 Hepatitis B     103296140 (PIK3CB)    05160 Hepatitis C     103296140 (PIK3CB)    05171 Coronavirus disease - COVID-19     103296140 (PIK3CB)    05164 Influenza A     103296140 (PIK3CB)    05162 Measles     103296140 (PIK3CB)    05163 Human cytomegalovirus infection     103296140 (PIK3CB)    05167 Kaposi sarcoma-associated herpesvirus infection     103296140 (PIK3CB)    05169 Epstein-Barr virus infection     103296140 (PIK3CB)    05165 Human papillomavirus infection     103296140 (PIK3CB)   09171 Infectious disease: bacterial    05135 Yersinia infection     103296140 (PIK3CB)    05100 Bacterial invasion of epithelial cells     103296140 (PIK3CB)   09174 Infectious disease: parasitic    05146 Amoebiasis     103296140 (PIK3CB)    05142 Chagas disease     103296140 (PIK3CB)   09164 Neurodegenerative disease    05010 Alzheimer disease     103296140 (PIK3CB)    05017 Spinocerebellar ataxia     103296140 (PIK3CB)    05020 Prion disease     103296140 (PIK3CB)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103296140 (PIK3CB)    05418 Fluid shear stress and atherosclerosis     103296140 (PIK3CB)    05415 Diabetic cardiomyopathy     103296140 (PIK3CB)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103296140 (PIK3CB)    04932 Non-alcoholic fatty liver disease     103296140 (PIK3CB)    04931 Insulin resistance     103296140 (PIK3CB)    04933 AGE-RAGE signaling pathway in diabetic complications     103296140 (PIK3CB)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103296140 (PIK3CB)    01524 Platinum drug resistance     103296140 (PIK3CB)    01522 Endocrine resistance     103296140 (PIK3CB)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:efus04131]     103296140 (PIK3CB) Enzymes [BR:efus01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      103296140 (PIK3CB) Membrane trafficking [BR:efus04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     103296140 (PIK3CB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 DUF4381 Tom37_C Motif Other DBs NCBI-GeneID:  103296140 NCBI-ProteinID:  XP_054564152 LinkDB All DBs Position 18:complement(30754795..30894465) Genome browser AA seq 1091 aa AA seqDB search MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISNIKQMLW TQIHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH ESSILENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKINELAIQKRLTIHWKEDE VSPYDYVLQISGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAI EAAINRNSSNLPLPLPPKKRIISHVWENNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGT ELLCKTIVSSEISGKNDHVWNEPLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTIN ASKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQT NPYTENATALHIRFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKEI LDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPKL PPREALELLDFNYPDQYVREYAVGCLRQMSKRIQSRIGKGKRFMGQSLEETSDEELSQYL LQLVQVLKYEPFLDCALSRFLLERALANRRIGQFLFWHLRSEVHIPAISIQFGVILEAYC RGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQ SPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQM LRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKD ALLNWLKEYNSGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKNGQLFHIDFG HILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNL FITLFALMLTAGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNW MAHTVRKDYRS NT seq 3276 nt NT seq  +upstreamnt  +downstreamnt atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagtg gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt tatatccagttggaggtacctcgggaagctaccatttctaatattaaacagatgttgtgg acacagattcataattacccaatgtttaacctccttatggaaattgactcctatatgttt gcatgtgtgaatcaaactgctgtatatgaggagctcgaagatgaaacaagaagactctgt gatgtcagaccttttcttccagttctcaaattagtgactagaagttgtgacccaggggaa aaattagactcaaaaattggagtccttataggaaaaggtttgcatgaatttgatgccttg aaggatcctgaagtgaatgaattccgaataaaaatgcgtaaatttagtgaggaaaaaatt cagtcgcttgtgggattgtcttggatggactggctaaagcagacatatccaccagagcat gaatcatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct gtgcattttgaaaattgtcaggatgtgtttagctttcaagtatctcctaatatgaatcct ataaaaataaatgaattggcaatccaaaaacgtttgactattcattggaaagaggatgaa gttagcccctatgactatgtgctgcaaatcagtgggagagtagaatatgtatttggtgat cacccactaatccaattccagtatatccggaactgtgtcatgaacaggaccttgccccat tttatacttgtggaatgttgcaagatcaaaaagatgtatgaacaggaaatgattgccata gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaacga attatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaagggaaat aaacttaacacagaagaaactgtaaaagttcatgtcagggctggcctttttcatggtact gaactcctgtgtaaaaccatcgtaagctcagagatatcaggaaaaaatgatcatgtttgg aatgaaccactggaatttgatattaatacttgtgacctgccacgaatggctagattatgt tttgctgtttatgcagttttggataaagtgaaaacaaagaaatcaactaaaacaattaat gcctctaaatatcagaccatcaggaaatctgggaaagtgcattatcctgtagcatgggta aatacgatggtttttgactttaaaggacagttgagatctggagacataatattgcacagc tggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaaaca aatccatatactgagaatgcaacagctttgcatatcagattcccagagaataaaaaacaa ccttattattaccctccctttgataagattatcgaaaaggcagctgagattgcaagcagc gatagtgctaatgtgtcaagtcggggtggaaaaaagtttcttgctgtactgaaggaaatc ttggacagggatcccttgtctcaactgtgtgagaatgaaatggatcttatttggactttg cgacaagactgcagagagaacttcccacagtcactgccaaagttattactgtcgatcaag tggaataaacttgaggatgttgctcagcttcaggcactacttcagatttggcctaaacta cctcctcgggaggccctggagcttctagatttcaactatccagatcagtacgttcgggaa tatgctgtaggctgcctgcgacagatgagcaaaaggatacagagcagaattggcaaagga aaaagattcatggggcaaagtctggaggaaaccagcgatgaagaactctcgcaatatctt ttacaactggtgcaagttttaaaatatgagccttttcttgattgtgccctctctagattc ctgttagaaagagcacttgctaatcggaggatagggcagtttctattttggcaccttaga tcagaagtgcacattcctgctatctccatacagtttggtgtcatccttgaagcgtactgc cggggaagcgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataaatta aaaactttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaaggcaaa gaggccatgcacacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcag tcccctctgaacccatgtgtcatcctctcggaactctatgttgaaaagtgtaaatacatg gattctaaaatgaagccgttgtggctggtatacaacaacaaggtatttggtgaggattca gtcggcgtgatttttaaaaatggtgatgatttacgacaggatatgttgacactccaaatg ctgcgcttgatggatttactctggaaagaagccggtctggatcttcggatgttgccttat ggctgtttagcgacaggagatcgctcaggcctcattgaagttgtgagcacctctgaaaca attgctgacattcagctgaacagtagcaatgtggctgctgcagcagccttcaataaagat gcccttctgaactggcttaaagaatacaattctggggatgacttggaccgagccattgag gagtttaccctgtcctgtgctggctactgtgtagcttcttatgtccttggaattggtgac agacatagtgacaacatcatggtaaaaaaaaatggccagctcttccacattgactttgga catattcttggaaattttaagtctaaatttggcattaaaagggagcgagtgccttttatt cttacctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaagttt ggcaggttccgccagtgttgtgaggatgcctatctgattttacgacggcacgggaacctc ttcatcactctctttgcactgatgttgactgcagggcttcctgagctcacatcagtcaag gatatacagtatcttaaggactcacttgccttagggaagagtgaagaagaagcactcaag caatttaagcaaaaatttgatgaggcactcagggaaagctggactactaaggtgaactgg atggcccacacggttcggaaagactacagatcttaa

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