Equus przewalskii (Przewalski's horse): 103549076 Help Entry 103549076         CDS       T04644                                  Symbol PIK3CD Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism epz  Equus przewalskii (Przewalski's horse) Pathway epz00562   Inositol phosphate metabolism epz01100   Metabolic pathways epz01521   EGFR tyrosine kinase inhibitor resistance epz01522   Endocrine resistance epz01524   Platinum drug resistance epz04012   ErbB signaling pathway epz04014   Ras signaling pathway epz04015   Rap1 signaling pathway epz04024   cAMP signaling pathway epz04062   Chemokine signaling pathway epz04066   HIF-1 signaling pathway epz04068   FoxO signaling pathway epz04070   Phosphatidylinositol signaling system epz04071   Sphingolipid signaling pathway epz04072   Phospholipase D signaling pathway epz04081   Hormone signaling epz04140   Autophagy - animal epz04150   mTOR signaling pathway epz04151   PI3K-Akt signaling pathway epz04152   AMPK signaling pathway epz04210   Apoptosis epz04211   Longevity regulating pathway epz04213   Longevity regulating pathway - multiple species epz04218   Cellular senescence epz04360   Axon guidance epz04370   VEGF signaling pathway epz04380   Osteoclast differentiation epz04510   Focal adhesion epz04550   Signaling pathways regulating pluripotency of stem cells epz04611   Platelet activation epz04613   Neutrophil extracellular trap formation epz04620   Toll-like receptor signaling pathway epz04625   C-type lectin receptor signaling pathway epz04630   JAK-STAT signaling pathway epz04650   Natural killer cell mediated cytotoxicity epz04660   T cell receptor signaling pathway epz04662   B cell receptor signaling pathway epz04664   Fc epsilon RI signaling pathway epz04666   Fc gamma R-mediated phagocytosis epz04668   TNF signaling pathway epz04670   Leukocyte transendothelial migration epz04722   Neurotrophin signaling pathway epz04725   Cholinergic synapse epz04750   Inflammatory mediator regulation of TRP channels epz04810   Regulation of actin cytoskeleton epz04910   Insulin signaling pathway epz04914   Progesterone-mediated oocyte maturation epz04915   Estrogen signaling pathway epz04917   Prolactin signaling pathway epz04919   Thyroid hormone signaling pathway epz04923   Regulation of lipolysis in adipocytes epz04926   Relaxin signaling pathway epz04929   GnRH secretion epz04930   Type II diabetes mellitus epz04931   Insulin resistance epz04932   Non-alcoholic fatty liver disease epz04933   AGE-RAGE signaling pathway in diabetic complications epz04935   Growth hormone synthesis, secretion and action epz04960   Aldosterone-regulated sodium reabsorption epz04973   Carbohydrate digestion and absorption epz05010   Alzheimer disease epz05017   Spinocerebellar ataxia epz05020   Prion disease epz05100   Bacterial invasion of epithelial cells epz05132   Salmonella infection epz05135   Yersinia infection epz05142   Chagas disease epz05146   Amoebiasis epz05160   Hepatitis C epz05161   Hepatitis B epz05162   Measles epz05163   Human cytomegalovirus infection epz05164   Influenza A epz05165   Human papillomavirus infection epz05166   Human T-cell leukemia virus 1 infection epz05167   Kaposi sarcoma-associated herpesvirus infection epz05168   Herpes simplex virus 1 infection epz05169   Epstein-Barr virus infection epz05170   Human immunodeficiency virus 1 infection epz05171   Coronavirus disease - COVID-19 epz05200   Pathways in cancer epz05203   Viral carcinogenesis epz05205   Proteoglycans in cancer epz05206   MicroRNAs in cancer epz05207   Chemical carcinogenesis - receptor activation epz05208   Chemical carcinogenesis - reactive oxygen species epz05210   Colorectal cancer epz05211   Renal cell carcinoma epz05212   Pancreatic cancer epz05213   Endometrial cancer epz05214   Glioma epz05215   Prostate cancer epz05218   Melanoma epz05220   Chronic myeloid leukemia epz05221   Acute myeloid leukemia epz05222   Small cell lung cancer epz05223   Non-small cell lung cancer epz05224   Breast cancer epz05225   Hepatocellular carcinoma epz05226   Gastric cancer epz05230   Central carbon metabolism in cancer epz05231   Choline metabolism in cancer epz05235   PD-L1 expression and PD-1 checkpoint pathway in cancer epz05415   Diabetic cardiomyopathy epz05417   Lipid and atherosclerosis epz05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:epz00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     103549076 (PIK3CD)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     103549076 (PIK3CD)    04015 Rap1 signaling pathway     103549076 (PIK3CD)    04630 JAK-STAT signaling pathway     103549076 (PIK3CD)    04668 TNF signaling pathway     103549076 (PIK3CD)    04066 HIF-1 signaling pathway     103549076 (PIK3CD)    04068 FoxO signaling pathway     103549076 (PIK3CD)    04070 Phosphatidylinositol signaling system     103549076 (PIK3CD)    04072 Phospholipase D signaling pathway     103549076 (PIK3CD)    04071 Sphingolipid signaling pathway     103549076 (PIK3CD)    04024 cAMP signaling pathway     103549076 (PIK3CD)    04151 PI3K-Akt signaling pathway     103549076 (PIK3CD)    04152 AMPK signaling pathway     103549076 (PIK3CD)    04150 mTOR signaling pathway     103549076 (PIK3CD)   09133 Signaling molecules and interaction    04081 Hormone signaling     103549076 (PIK3CD)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     103549076 (PIK3CD)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     103549076 (PIK3CD)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103549076 (PIK3CD)    04613 Neutrophil extracellular trap formation     103549076 (PIK3CD)    04620 Toll-like receptor signaling pathway     103549076 (PIK3CD)    04650 Natural killer cell mediated cytotoxicity     103549076 (PIK3CD)    04660 T cell receptor signaling pathway     103549076 (PIK3CD)    04662 B cell receptor signaling pathway     103549076 (PIK3CD)    04664 Fc epsilon RI signaling pathway     103549076 (PIK3CD)    04666 Fc gamma R-mediated phagocytosis     103549076 (PIK3CD)    04670 Leukocyte transendothelial migration     103549076 (PIK3CD)    04062 Chemokine signaling pathway     103549076 (PIK3CD)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     103549076 (PIK3CD)    04929 GnRH secretion     103549076 (PIK3CD)    04915 Estrogen signaling pathway     103549076 (PIK3CD)    04917 Prolactin signaling pathway     103549076 (PIK3CD)    04926 Relaxin signaling pathway     103549076 (PIK3CD)    04935 Growth hormone synthesis, secretion and action     103549076 (PIK3CD)    04919 Thyroid hormone signaling pathway     103549076 (PIK3CD)   09154 Digestive system    04973 Carbohydrate digestion and absorption     103549076 (PIK3CD)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     103549076 (PIK3CD)   09156 Nervous system    04725 Cholinergic synapse     103549076 (PIK3CD)    04722 Neurotrophin signaling pathway     103549076 (PIK3CD)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     103549076 (PIK3CD)   09158 Development and regeneration    04360 Axon guidance     103549076 (PIK3CD)    04380 Osteoclast differentiation     103549076 (PIK3CD)   09149 Aging    04211 Longevity regulating pathway     103549076 (PIK3CD)    04213 Longevity regulating pathway - multiple species     103549076 (PIK3CD)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103549076 (PIK3CD)    05206 MicroRNAs in cancer     103549076 (PIK3CD)    05205 Proteoglycans in cancer     103549076 (PIK3CD)    05207 Chemical carcinogenesis - receptor activation     103549076 (PIK3CD)    05208 Chemical carcinogenesis - reactive oxygen species     103549076 (PIK3CD)    05203 Viral carcinogenesis     103549076 (PIK3CD)    05230 Central carbon metabolism in cancer     103549076 (PIK3CD)    05231 Choline metabolism in cancer     103549076 (PIK3CD)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103549076 (PIK3CD)   09162 Cancer: specific types    05210 Colorectal cancer     103549076 (PIK3CD)    05212 Pancreatic cancer     103549076 (PIK3CD)    05225 Hepatocellular carcinoma     103549076 (PIK3CD)    05226 Gastric cancer     103549076 (PIK3CD)    05214 Glioma     103549076 (PIK3CD)    05221 Acute myeloid leukemia     103549076 (PIK3CD)    05220 Chronic myeloid leukemia     103549076 (PIK3CD)    05218 Melanoma     103549076 (PIK3CD)    05211 Renal cell carcinoma     103549076 (PIK3CD)    05215 Prostate cancer     103549076 (PIK3CD)    05213 Endometrial cancer     103549076 (PIK3CD)    05224 Breast cancer     103549076 (PIK3CD)    05222 Small cell lung cancer     103549076 (PIK3CD)    05223 Non-small cell lung cancer     103549076 (PIK3CD)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103549076 (PIK3CD)    05170 Human immunodeficiency virus 1 infection     103549076 (PIK3CD)    05161 Hepatitis B     103549076 (PIK3CD)    05160 Hepatitis C     103549076 (PIK3CD)    05171 Coronavirus disease - COVID-19     103549076 (PIK3CD)    05164 Influenza A     103549076 (PIK3CD)    05162 Measles     103549076 (PIK3CD)    05163 Human cytomegalovirus infection     103549076 (PIK3CD)    05167 Kaposi sarcoma-associated herpesvirus infection     103549076 (PIK3CD)    05169 Epstein-Barr virus infection     103549076 (PIK3CD)    05165 Human papillomavirus infection     103549076 (PIK3CD)   09171 Infectious disease: bacterial    05135 Yersinia infection     103549076 (PIK3CD)    05100 Bacterial invasion of epithelial cells     103549076 (PIK3CD)   09174 Infectious disease: parasitic    05146 Amoebiasis     103549076 (PIK3CD)    05142 Chagas disease     103549076 (PIK3CD)   09164 Neurodegenerative disease    05010 Alzheimer disease     103549076 (PIK3CD)    05017 Spinocerebellar ataxia     103549076 (PIK3CD)    05020 Prion disease     103549076 (PIK3CD)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     103549076 (PIK3CD)    05418 Fluid shear stress and atherosclerosis     103549076 (PIK3CD)    05415 Diabetic cardiomyopathy     103549076 (PIK3CD)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     103549076 (PIK3CD)    04932 Non-alcoholic fatty liver disease     103549076 (PIK3CD)    04931 Insulin resistance     103549076 (PIK3CD)    04933 AGE-RAGE signaling pathway in diabetic complications     103549076 (PIK3CD)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103549076 (PIK3CD)    01524 Platinum drug resistance     103549076 (PIK3CD)    01522 Endocrine resistance     103549076 (PIK3CD)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:epz04131]     103549076 (PIK3CD) Enzymes [BR:epz01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      103549076 (PIK3CD) Membrane trafficking [BR:epz04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     103549076 (PIK3CD) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI3_PI4_kinase PI3Ka PI3K_p85B PI3K_rbd PI3K_C2 Motif Other DBs NCBI-GeneID:  103549076 NCBI-ProteinID:  XP_070466989 LinkDB All DBs Position 2:complement(41456494..41511515) Genome browser AA seq 1044 aa AA seqDB search MPPGVDCPMEFWTKEENQSVAVDFLLPTGVYLNFPVSRNANLSTIKKVLWHRAQYEPLFH MLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPFLPVLRLVAREGDRVKKLINSQISLV IGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAARRQQLGWEAWLQYSFPLQLEPLAGNWGA STLRFPSRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT LQVNGRLEYLYGSYPLCRFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPTPQVQKPR TKPPPIPVKKPSSVSLWSLEQPFCVELIQGSKVNADERMKLVVQAGLFHGNETLCKTVSS SEVSVCSEPVWKQRLEFDINVCDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW ANLMLFDYKDQLKTGECCLYMWPSVPDEKGELLNPTGTVRNNPNTESAAALVISLPEVAP HPVYYPALDKILELGRPGEHGRFTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDRHVGSFAIKSL RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV ALRFGLIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKATKPHTKELMHLCMR QETYLEALSHLQSPLDPSILLAEVCVEQCTFMDSKMKPLWVMYSNEEAGSDGSVGIIFKN GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLSTGDRTGLIEVVLHSDTIANIQLN KSNMAATAAFNKDALLNWLKSKNPGEALERAIEEFTLSCAGYCVATYVLGIGDRHSDNIM IRENGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN EALRESWKTKVNWLAHNVSKDNRQ NT seq 3135 nt NT seq  +upstreamnt  +downstreamnt atgccccctggggttgactgccccatggaattctggaccaaggaggagaatcagagcgtg gctgttgacttcctgctgcccacgggggtctatctgaacttccctgtgtcccgaaatgcc aacctcagcaccatcaagaaggtgttgtggcaccgagcccagtatgagccactcttccac atgctcagtgaccccgaggcctatgtgttcacctgcgtcaaccagactgcggagcagcag gagctggaggacgagcagcggcggctgtgtgacatccagcccttcctgccggttctgcgc ctggtggcccgcgagggcgacagggtgaagaagctcatcaactcgcagatcagccttgtc atcggcaaaggcctccatgagtttgactccttgcgtgacccagaagtgaatgactttcgc accaagatgcgccagttctgtgaggaggccgctgcccgccggcaacagctgggctgggag gcctggctacagtacagctttcccctgcagctggagcccttggcgggaaactggggagcc agcaccctacggttccccagccgggcccttctggtcaacgtcaagttcgagggcagtgag gagagcttcaccttccaggtgtccaccaaggacgtgcccctggcactgatggcctgtgcc ctccggaagaaggccacggtgttccggcagcccctggtggagcagcccgaggactacacg ctgcaggtgaacgggagactcgagtacctgtacggcagctaccccctctgccgcttccag tacatctgcagctgcctgcacagcgggctgacccctcatctgaccatggtgcactcctcc tccatcctcgccatgcgggacgaacagagcaaccccaccccccaagtccaaaaaccgcgc accaaaccgccccccattcccgtgaagaagccctcctctgtgtccctgtggtccctggag cagccgttctgcgtcgagctcatccagggcagcaaagtgaacgcagatgagcggatgaag ctggtggtgcaggctgggcttttccatggtaatgagacgctctgcaagacggtgtccagc tcggaggtgagcgtgtgctcagagcctgtgtggaaacagcggctggagtttgacatcaac gtctgcgatctgccgcgcatggcccgtctctgctttgcactttacgccgtgattgagaag gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg gccaacctcatgctgtttgactacaaggaccagctcaagactggggaatgctgcctctac atgtggccctccgtcccagatgagaaaggggagctgctgaaccccacgggaaccgtgcgc aataaccccaacactgagagcgctgccgccctggtcatctccctccccgaggtggccccc caccccgtgtactaccctgcccttgacaagatcttggagctggggcggcccggggagcat gggcgcttcaccgaggaggagcagctgcagctgcgggagatcctggagcggcgggggtcc ggggagctgtatgagcatgagaaggacctggtgtggaagatgcgacacgaggtccaggag cacttccccgaggcactggcccggctgctgctggtcaccaagtggaacaagcatgaggac gtggcccagatgctctacctgctgtgctcctggcctgagctgcctgtgctgagcgccctg gagctgctggacttcagcttccccgaccgccacgtgggctccttcgccatcaagtccctg cggaaactgacggacgacgagcttttccagtacctgctgcagctggtgcaggtgcttaag tacgagtcctacctcgactgtgagctgaccaaattcctgctggaccgggccctggccaac cgcaagatcggccacttcctcttctggcacctccggtccgagatgcacgtgccgtcggtg gccctgcgcttcggcctcatcatggaggcgtactgcaggggcagcacccaccacatgaag gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaacgactttgtcaaa gtgagctcccagaaggccaccaagccccacaccaaggagctgatgcacctgtgcatgcgc caggagacctacctggaggccctctcccacctgcagtcgccgctcgaccccagcatcctg ctggctgaagtctgtgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg gtcatgtacagcaacgaggaggcgggcagcgatggcagcgtgggcatcatatttaagaac ggggatgacctccgccaggacatgctgactctgcagatgatccagctcatggacgttctg tggaagcaggaggggttggacctgaggatgaccccctatggctgcctctccactggggac cgcacgggcctcatcgaggtggtgcttcactcagacaccattgccaacatccagctgaac aagagcaacatggcagccacggccgccttcaacaaggatgccctgctcaactggctcaag tctaagaaccctggggaggccctggaacgagctattgaggagttcaccctctcctgcgct ggctactgtgtggccacatacgtgctgggcatcggtgatcggcacagcgacaacatcatg atccgcgagaatgggcagctgttccacattgattttggccactttctggggaatttcaag accaagtttggaatcaaccgtgagcgagtcccattcatcctcacctatgactttgtccat gtgatccagcaggggaagactaataatagtgagaaattcgaaaggttccggggctactgt gagagggcctacaccatcctgcggcgccacgggctgctcttcctgcacctcttcgccctg atgcgggcggccggcctgcctgagctcagctgctctaaagacatccaatatctcaaggac tctctggccttgggaaaaacggaggaggaggctctgaagcacttccgagtgaagtttaac gaagcgctccgggagagctggaagaccaaagtgaattggctggcccacaacgtgtccaaa gacaacaggcaatag

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