Nomascus leucogenys (northern white-cheeked gibbon): 100580872 Help Entry 100580872         CDS       T03265                                  Symbol PIK3CD Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism nle  Nomascus leucogenys (northern white-cheeked gibbon) Pathway nle00562   Inositol phosphate metabolism nle01100   Metabolic pathways nle01521   EGFR tyrosine kinase inhibitor resistance nle01522   Endocrine resistance nle01524   Platinum drug resistance nle04012   ErbB signaling pathway nle04014   Ras signaling pathway nle04015   Rap1 signaling pathway nle04024   cAMP signaling pathway nle04062   Chemokine signaling pathway nle04066   HIF-1 signaling pathway nle04068   FoxO signaling pathway nle04070   Phosphatidylinositol signaling system nle04071   Sphingolipid signaling pathway nle04072   Phospholipase D signaling pathway nle04081   Hormone signaling nle04140   Autophagy - animal nle04150   mTOR signaling pathway nle04151   PI3K-Akt signaling pathway nle04152   AMPK signaling pathway nle04210   Apoptosis nle04211   Longevity regulating pathway nle04213   Longevity regulating pathway - multiple species nle04218   Cellular senescence nle04360   Axon guidance nle04370   VEGF signaling pathway nle04380   Osteoclast differentiation nle04510   Focal adhesion nle04550   Signaling pathways regulating pluripotency of stem cells nle04611   Platelet activation nle04613   Neutrophil extracellular trap formation nle04620   Toll-like receptor signaling pathway nle04625   C-type lectin receptor signaling pathway nle04630   JAK-STAT signaling pathway nle04650   Natural killer cell mediated cytotoxicity nle04660   T cell receptor signaling pathway nle04662   B cell receptor signaling pathway nle04664   Fc epsilon RI signaling pathway nle04666   Fc gamma R-mediated phagocytosis nle04668   TNF signaling pathway nle04670   Leukocyte transendothelial migration nle04722   Neurotrophin signaling pathway nle04725   Cholinergic synapse nle04750   Inflammatory mediator regulation of TRP channels nle04810   Regulation of actin cytoskeleton nle04910   Insulin signaling pathway nle04914   Progesterone-mediated oocyte maturation nle04915   Estrogen signaling pathway nle04917   Prolactin signaling pathway nle04919   Thyroid hormone signaling pathway nle04923   Regulation of lipolysis in adipocytes nle04926   Relaxin signaling pathway nle04929   GnRH secretion nle04930   Type II diabetes mellitus nle04931   Insulin resistance nle04932   Non-alcoholic fatty liver disease nle04933   AGE-RAGE signaling pathway in diabetic complications nle04935   Growth hormone synthesis, secretion and action nle04960   Aldosterone-regulated sodium reabsorption nle04973   Carbohydrate digestion and absorption nle05010   Alzheimer disease nle05017   Spinocerebellar ataxia nle05020   Prion disease nle05100   Bacterial invasion of epithelial cells nle05132   Salmonella infection nle05135   Yersinia infection nle05142   Chagas disease nle05146   Amoebiasis nle05160   Hepatitis C nle05161   Hepatitis B nle05162   Measles nle05163   Human cytomegalovirus infection nle05164   Influenza A nle05165   Human papillomavirus infection nle05166   Human T-cell leukemia virus 1 infection nle05167   Kaposi sarcoma-associated herpesvirus infection nle05168   Herpes simplex virus 1 infection nle05169   Epstein-Barr virus infection nle05170   Human immunodeficiency virus 1 infection nle05171   Coronavirus disease - COVID-19 nle05200   Pathways in cancer nle05203   Viral carcinogenesis nle05205   Proteoglycans in cancer nle05206   MicroRNAs in cancer nle05207   Chemical carcinogenesis - receptor activation nle05208   Chemical carcinogenesis - reactive oxygen species nle05210   Colorectal cancer nle05211   Renal cell carcinoma nle05212   Pancreatic cancer nle05213   Endometrial cancer nle05214   Glioma nle05215   Prostate cancer nle05218   Melanoma nle05220   Chronic myeloid leukemia nle05221   Acute myeloid leukemia nle05222   Small cell lung cancer nle05223   Non-small cell lung cancer nle05224   Breast cancer nle05225   Hepatocellular carcinoma nle05226   Gastric cancer nle05230   Central carbon metabolism in cancer nle05231   Choline metabolism in cancer nle05235   PD-L1 expression and PD-1 checkpoint pathway in cancer nle05415   Diabetic cardiomyopathy nle05417   Lipid and atherosclerosis nle05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:nle00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     100580872 (PIK3CD)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     100580872 (PIK3CD)    04015 Rap1 signaling pathway     100580872 (PIK3CD)    04630 JAK-STAT signaling pathway     100580872 (PIK3CD)    04668 TNF signaling pathway     100580872 (PIK3CD)    04066 HIF-1 signaling pathway     100580872 (PIK3CD)    04068 FoxO signaling pathway     100580872 (PIK3CD)    04070 Phosphatidylinositol signaling system     100580872 (PIK3CD)    04072 Phospholipase D signaling pathway     100580872 (PIK3CD)    04071 Sphingolipid signaling pathway     100580872 (PIK3CD)    04024 cAMP signaling pathway     100580872 (PIK3CD)    04151 PI3K-Akt signaling pathway     100580872 (PIK3CD)    04152 AMPK signaling pathway     100580872 (PIK3CD)    04150 mTOR signaling pathway     100580872 (PIK3CD)   09133 Signaling molecules and interaction    04081 Hormone signaling     100580872 (PIK3CD)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     100580872 (PIK3CD)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     100580872 (PIK3CD)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     100580872 (PIK3CD)    04613 Neutrophil extracellular trap formation     100580872 (PIK3CD)    04620 Toll-like receptor signaling pathway     100580872 (PIK3CD)    04650 Natural killer cell mediated cytotoxicity     100580872 (PIK3CD)    04660 T cell receptor signaling pathway     100580872 (PIK3CD)    04662 B cell receptor signaling pathway     100580872 (PIK3CD)    04664 Fc epsilon RI signaling pathway     100580872 (PIK3CD)    04666 Fc gamma R-mediated phagocytosis     100580872 (PIK3CD)    04670 Leukocyte transendothelial migration     100580872 (PIK3CD)    04062 Chemokine signaling pathway     100580872 (PIK3CD)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     100580872 (PIK3CD)    04929 GnRH secretion     100580872 (PIK3CD)    04915 Estrogen signaling pathway     100580872 (PIK3CD)    04917 Prolactin signaling pathway     100580872 (PIK3CD)    04926 Relaxin signaling pathway     100580872 (PIK3CD)    04935 Growth hormone synthesis, secretion and action     100580872 (PIK3CD)    04919 Thyroid hormone signaling pathway     100580872 (PIK3CD)   09154 Digestive system    04973 Carbohydrate digestion and absorption     100580872 (PIK3CD)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     100580872 (PIK3CD)   09156 Nervous system    04725 Cholinergic synapse     100580872 (PIK3CD)    04722 Neurotrophin signaling pathway     100580872 (PIK3CD)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     100580872 (PIK3CD)   09158 Development and regeneration    04360 Axon guidance     100580872 (PIK3CD)    04380 Osteoclast differentiation     100580872 (PIK3CD)   09149 Aging    04211 Longevity regulating pathway     100580872 (PIK3CD)    04213 Longevity regulating pathway - multiple species     100580872 (PIK3CD)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     100580872 (PIK3CD)    05206 MicroRNAs in cancer     100580872 (PIK3CD)    05205 Proteoglycans in cancer     100580872 (PIK3CD)    05207 Chemical carcinogenesis - receptor activation     100580872 (PIK3CD)    05208 Chemical carcinogenesis - reactive oxygen species     100580872 (PIK3CD)    05203 Viral carcinogenesis     100580872 (PIK3CD)    05230 Central carbon metabolism in cancer     100580872 (PIK3CD)    05231 Choline metabolism in cancer     100580872 (PIK3CD)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     100580872 (PIK3CD)   09162 Cancer: specific types    05210 Colorectal cancer     100580872 (PIK3CD)    05212 Pancreatic cancer     100580872 (PIK3CD)    05225 Hepatocellular carcinoma     100580872 (PIK3CD)    05226 Gastric cancer     100580872 (PIK3CD)    05214 Glioma     100580872 (PIK3CD)    05221 Acute myeloid leukemia     100580872 (PIK3CD)    05220 Chronic myeloid leukemia     100580872 (PIK3CD)    05218 Melanoma     100580872 (PIK3CD)    05211 Renal cell carcinoma     100580872 (PIK3CD)    05215 Prostate cancer     100580872 (PIK3CD)    05213 Endometrial cancer     100580872 (PIK3CD)    05224 Breast cancer     100580872 (PIK3CD)    05222 Small cell lung cancer     100580872 (PIK3CD)    05223 Non-small cell lung cancer     100580872 (PIK3CD)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     100580872 (PIK3CD)    05170 Human immunodeficiency virus 1 infection     100580872 (PIK3CD)    05161 Hepatitis B     100580872 (PIK3CD)    05160 Hepatitis C     100580872 (PIK3CD)    05171 Coronavirus disease - COVID-19     100580872 (PIK3CD)    05164 Influenza A     100580872 (PIK3CD)    05162 Measles     100580872 (PIK3CD)    05163 Human cytomegalovirus infection     100580872 (PIK3CD)    05167 Kaposi sarcoma-associated herpesvirus infection     100580872 (PIK3CD)    05169 Epstein-Barr virus infection     100580872 (PIK3CD)    05165 Human papillomavirus infection     100580872 (PIK3CD)   09171 Infectious disease: bacterial    05135 Yersinia infection     100580872 (PIK3CD)    05100 Bacterial invasion of epithelial cells     100580872 (PIK3CD)   09174 Infectious disease: parasitic    05146 Amoebiasis     100580872 (PIK3CD)    05142 Chagas disease     100580872 (PIK3CD)   09164 Neurodegenerative disease    05010 Alzheimer disease     100580872 (PIK3CD)    05017 Spinocerebellar ataxia     100580872 (PIK3CD)    05020 Prion disease     100580872 (PIK3CD)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     100580872 (PIK3CD)    05418 Fluid shear stress and atherosclerosis     100580872 (PIK3CD)    05415 Diabetic cardiomyopathy     100580872 (PIK3CD)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     100580872 (PIK3CD)    04932 Non-alcoholic fatty liver disease     100580872 (PIK3CD)    04931 Insulin resistance     100580872 (PIK3CD)    04933 AGE-RAGE signaling pathway in diabetic complications     100580872 (PIK3CD)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     100580872 (PIK3CD)    01524 Platinum drug resistance     100580872 (PIK3CD)    01522 Endocrine resistance     100580872 (PIK3CD)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:nle04131]     100580872 (PIK3CD) Enzymes [BR:nle01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      100580872 (PIK3CD) Membrane trafficking [BR:nle04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     100580872 (PIK3CD) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Motif Other DBs NCBI-GeneID:  100580872 NCBI-ProteinID:  XP_030661447 Ensembl:  ENSNLEG00000009299 LinkDB All DBs Position 24:10481508..10555068 Genome browser AA seq 1044 aa AA seqDB search MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSARTWGP GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR AKPPPIPGKKPSSVSLWSLEQPFCIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE HFPEALARLLLVTKWNRHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN EALRESWKTKVNWLAHNVSKDNRQ NT seq 3135 nt NT seq  +upstreamnt  +downstreamnt atgccccctggggtggactgccccatggaattctggaccaaggaggagaatcagagcgtc gtggttgacttcctgctgcccacaggggtctacctgaacttccctgtgtcccgcaatgcc aacctcagcaccatcaagcagctgctgtggcaccgcgcccagtatgagccgctcttccac atgctcagtggccccgaggcctatgtgttcacctgcatcaaccagacagcggagcagcag gagctggaggacgagcaaaggcgtctgtgtgacgtgcagcccttcctgcccgtcctgcgc ctggtggcccgcgagggcgaccgcgtgaagaagctcatcaactcacagatcagcctcctc atcggcaaaggcctccacgagtttgactccttgtgcgacccagaagtgaacgactttcgc gccaagatgtgccaattctgcgaggaggcggccgctcgccggcagcagctgggctgggag gcctggctgcagtacagtttccccctgcagctggagccctcggctcgaacctgggggcct ggcaccctgcggctcccgaaccgggcccttctggtcaacgttaagtttgaaggcagcgag gagagcttcaccttccaggtgtctaccaaggacgtgccgctggcgctgatggcctgtgcc ctgcggaagaaggccacggtgttccggcagccgctggtggagcagccggaggactacacg ctgcaggtgaacggcaggcatgagtacctgtacggcagctacccactctgccagttccag tacatctgcagctgcctgcacagtgggctgacccctcacctgaccatggtccattcctcc tccatcctcgccatgcgggatgagcagagcaaccctgccccccaggtccagaaaccgcgt gccaaaccacctcccattcctgggaagaagccttcctctgtgtccctgtggtccctggag cagccgttctgcatcgagctcatccagggcagcaaagtgaacgccgacgagcggatgaag ctggtggtgcaggccgggcttttccacggcaacgagatgctgtgcaagacggtgtccagc tcggaggtgagtgtgtgctcggagcccgtgtggaagcagcggctggagttcgacatcaac atctgcgacctgccccgcatggcccgtctctgctttgcgctgtacgccgtgatcgagaaa gccaagaaggctcgctccaccaagaagaagtccaagaaggcggactgccccattgcctgg gccaacctcatgctgtttgactacaaggaccagcttaagaccggggaacgctgcctctac atgtggccctccgtcccagatgagaagggcgagctgctgaaccccacgggtactgtgcgc agtaaccccaacacggatagcgccgccgccctgctcatctgcctgcccgaggtggccccg caccccgtgtactatcccgccctggagaagatcttggagctggggcggcacagcgagtgt gtgcatgtcactgaggaggagcagctgcagctgcgggaaattctggagcggcgggggtct ggggagctgtatgagcacgagaaggacctggtgtggaagctgcggcatgaagtccaggag cacttcccggaggcgctggcccggctgctgctggtcactaagtggaacaggcatgaggat gtggcccagatgctctacctgctgtgctcctggccggagctgcccgtcctgagcgccctg gagctgctagacttcagcttccctgattgccacgtaggctccttcgccatcaagtcgctg cggaaactgacggacgatgagctgttccagtacctgctgcagctggtgcaggtgctcaag tacgagtcctacctggactgcgagctgaccaaattcctgctggaccgggccctggccaac cgcaagatcggccacttccttttctggcacctccgctccgagatgcacgtgccgtccgtg gccctgcgcttcggcctcatcctggaggcctactgcaggggcagcacccaccacatgaag gtgctgatgaagcagggggaagcactgagcaaactgaaggccctgaatgacttcgtcaag ctgagctctcagaagacccctaagccccagaccaaggagctgatgcacttgtgcatgcgg caggaggcctacctagaggccctctcccacttgcagtccccactcgaccccagcaccctg ctggctgaagtctgcgtggagcagtgcaccttcatggactccaagatgaagcccctgtgg atcatgtacagcaacgaggaggcaggcagcggcggcagcgtgggcatcatcttcaagaat ggggatgacctccggcaggacatgttgaccctgcagatgatccagctcatggacgtcctg tggaagcaggaggggctggacctgaggatgaccccctacggctgcctccccaccggggac cgcacaggtctcatcgaggtggtactccgctccgacaccatcgccaacatccaacttaac aagagcaacatggcagccacagccgccttcaacaaggacgccctgctcaactggctgaag tccaagaacccgggggaggccctggatcgagccattgaggagttcaccctctcctgtgct ggctactgtgtggccacatacgtgctgggcatcggcgatcggcacagcgacaacatcatg atccgagagagtgggcagctgttccacattgattttggccactttctggggaatttcaag accaagtttggaatcaaccgcgagcgtgtcccattcatcctcacctatgactttgtccat gtgattcagcaggggaagactaataatagtgagaaatttgaacgcttccggggctactgt gaaagggcctacaccatcctgcggcgccacgggcttctcttcctccacctctttgccctg atgcgggcggcaggccttcctgagctcagctgctccaaagacatccagtatctcaaggac tccctggcactggggaaaacagaggaggaggcgctgaagcacttccgagtgaagtttaac gaagccctccgtgagagctggaaaaccaaagtgaactggctggcccacaacgtgtccaaa gacaacaggcagtag

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