Propithecus coquereli (Coquerel's sifaka): 105806240 Help Entry 105806240         CDS       T08746                                  Symbol PIK3CA Name (RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism pcoq  Propithecus coquereli (Coquerel's sifaka) Pathway pcoq00562   Inositol phosphate metabolism pcoq01100   Metabolic pathways pcoq01521   EGFR tyrosine kinase inhibitor resistance pcoq01522   Endocrine resistance pcoq01524   Platinum drug resistance pcoq04012   ErbB signaling pathway pcoq04014   Ras signaling pathway pcoq04015   Rap1 signaling pathway pcoq04024   cAMP signaling pathway pcoq04062   Chemokine signaling pathway pcoq04066   HIF-1 signaling pathway pcoq04068   FoxO signaling pathway pcoq04070   Phosphatidylinositol signaling system pcoq04071   Sphingolipid signaling pathway pcoq04072   Phospholipase D signaling pathway pcoq04081   Hormone signaling pcoq04140   Autophagy - animal pcoq04150   mTOR signaling pathway pcoq04151   PI3K-Akt signaling pathway pcoq04152   AMPK signaling pathway pcoq04210   Apoptosis pcoq04211   Longevity regulating pathway pcoq04213   Longevity regulating pathway - multiple species pcoq04218   Cellular senescence pcoq04360   Axon guidance pcoq04370   VEGF signaling pathway pcoq04380   Osteoclast differentiation pcoq04510   Focal adhesion pcoq04550   Signaling pathways regulating pluripotency of stem cells pcoq04611   Platelet activation pcoq04613   Neutrophil extracellular trap formation pcoq04620   Toll-like receptor signaling pathway pcoq04625   C-type lectin receptor signaling pathway pcoq04630   JAK-STAT signaling pathway pcoq04650   Natural killer cell mediated cytotoxicity pcoq04660   T cell receptor signaling pathway pcoq04662   B cell receptor signaling pathway pcoq04664   Fc epsilon RI signaling pathway pcoq04666   Fc gamma R-mediated phagocytosis pcoq04668   TNF signaling pathway pcoq04670   Leukocyte transendothelial migration pcoq04722   Neurotrophin signaling pathway pcoq04725   Cholinergic synapse pcoq04750   Inflammatory mediator regulation of TRP channels pcoq04810   Regulation of actin cytoskeleton pcoq04910   Insulin signaling pathway pcoq04914   Progesterone-mediated oocyte maturation pcoq04915   Estrogen signaling pathway pcoq04917   Prolactin signaling pathway pcoq04919   Thyroid hormone signaling pathway pcoq04923   Regulation of lipolysis in adipocytes pcoq04926   Relaxin signaling pathway pcoq04929   GnRH secretion pcoq04930   Type II diabetes mellitus pcoq04931   Insulin resistance pcoq04932   Non-alcoholic fatty liver disease pcoq04933   AGE-RAGE signaling pathway in diabetic complications pcoq04935   Growth hormone synthesis, secretion and action pcoq04960   Aldosterone-regulated sodium reabsorption pcoq04973   Carbohydrate digestion and absorption pcoq05010   Alzheimer disease pcoq05017   Spinocerebellar ataxia pcoq05020   Prion disease pcoq05100   Bacterial invasion of epithelial cells pcoq05132   Salmonella infection pcoq05135   Yersinia infection pcoq05142   Chagas disease pcoq05146   Amoebiasis pcoq05160   Hepatitis C pcoq05161   Hepatitis B pcoq05162   Measles pcoq05163   Human cytomegalovirus infection pcoq05164   Influenza A pcoq05165   Human papillomavirus infection pcoq05166   Human T-cell leukemia virus 1 infection pcoq05167   Kaposi sarcoma-associated herpesvirus infection pcoq05168   Herpes simplex virus 1 infection pcoq05169   Epstein-Barr virus infection pcoq05170   Human immunodeficiency virus 1 infection pcoq05171   Coronavirus disease - COVID-19 pcoq05200   Pathways in cancer pcoq05203   Viral carcinogenesis pcoq05205   Proteoglycans in cancer pcoq05206   MicroRNAs in cancer pcoq05207   Chemical carcinogenesis - receptor activation pcoq05208   Chemical carcinogenesis - reactive oxygen species pcoq05210   Colorectal cancer pcoq05211   Renal cell carcinoma pcoq05212   Pancreatic cancer pcoq05213   Endometrial cancer pcoq05214   Glioma pcoq05215   Prostate cancer pcoq05218   Melanoma pcoq05220   Chronic myeloid leukemia pcoq05221   Acute myeloid leukemia pcoq05222   Small cell lung cancer pcoq05223   Non-small cell lung cancer pcoq05224   Breast cancer pcoq05225   Hepatocellular carcinoma pcoq05226   Gastric cancer pcoq05230   Central carbon metabolism in cancer pcoq05231   Choline metabolism in cancer pcoq05235   PD-L1 expression and PD-1 checkpoint pathway in cancer pcoq05415   Diabetic cardiomyopathy pcoq05417   Lipid and atherosclerosis pcoq05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:pcoq00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     105806240 (PIK3CA)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     105806240 (PIK3CA)    04015 Rap1 signaling pathway     105806240 (PIK3CA)    04630 JAK-STAT signaling pathway     105806240 (PIK3CA)    04668 TNF signaling pathway     105806240 (PIK3CA)    04066 HIF-1 signaling pathway     105806240 (PIK3CA)    04068 FoxO signaling pathway     105806240 (PIK3CA)    04070 Phosphatidylinositol signaling system     105806240 (PIK3CA)    04072 Phospholipase D signaling pathway     105806240 (PIK3CA)    04071 Sphingolipid signaling pathway     105806240 (PIK3CA)    04024 cAMP signaling pathway     105806240 (PIK3CA)    04151 PI3K-Akt signaling pathway     105806240 (PIK3CA)    04152 AMPK signaling pathway     105806240 (PIK3CA)    04150 mTOR signaling pathway     105806240 (PIK3CA)   09133 Signaling molecules and interaction    04081 Hormone signaling     105806240 (PIK3CA)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     105806240 (PIK3CA)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     105806240 (PIK3CA)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     105806240 (PIK3CA)    04613 Neutrophil extracellular trap formation     105806240 (PIK3CA)    04620 Toll-like receptor signaling pathway     105806240 (PIK3CA)    04650 Natural killer cell mediated cytotoxicity     105806240 (PIK3CA)    04660 T cell receptor signaling pathway     105806240 (PIK3CA)    04662 B cell receptor signaling pathway     105806240 (PIK3CA)    04664 Fc epsilon RI signaling pathway     105806240 (PIK3CA)    04666 Fc gamma R-mediated phagocytosis     105806240 (PIK3CA)    04670 Leukocyte transendothelial migration     105806240 (PIK3CA)    04062 Chemokine signaling pathway     105806240 (PIK3CA)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     105806240 (PIK3CA)    04929 GnRH secretion     105806240 (PIK3CA)    04915 Estrogen signaling pathway     105806240 (PIK3CA)    04917 Prolactin signaling pathway     105806240 (PIK3CA)    04926 Relaxin signaling pathway     105806240 (PIK3CA)    04935 Growth hormone synthesis, secretion and action     105806240 (PIK3CA)    04919 Thyroid hormone signaling pathway     105806240 (PIK3CA)   09154 Digestive system    04973 Carbohydrate digestion and absorption     105806240 (PIK3CA)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     105806240 (PIK3CA)   09156 Nervous system    04725 Cholinergic synapse     105806240 (PIK3CA)    04722 Neurotrophin signaling pathway     105806240 (PIK3CA)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     105806240 (PIK3CA)   09158 Development and regeneration    04360 Axon guidance     105806240 (PIK3CA)    04380 Osteoclast differentiation     105806240 (PIK3CA)   09149 Aging    04211 Longevity regulating pathway     105806240 (PIK3CA)    04213 Longevity regulating pathway - multiple species     105806240 (PIK3CA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     105806240 (PIK3CA)    05206 MicroRNAs in cancer     105806240 (PIK3CA)    05205 Proteoglycans in cancer     105806240 (PIK3CA)    05207 Chemical carcinogenesis - receptor activation     105806240 (PIK3CA)    05208 Chemical carcinogenesis - reactive oxygen species     105806240 (PIK3CA)    05203 Viral carcinogenesis     105806240 (PIK3CA)    05230 Central carbon metabolism in cancer     105806240 (PIK3CA)    05231 Choline metabolism in cancer     105806240 (PIK3CA)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     105806240 (PIK3CA)   09162 Cancer: specific types    05210 Colorectal cancer     105806240 (PIK3CA)    05212 Pancreatic cancer     105806240 (PIK3CA)    05225 Hepatocellular carcinoma     105806240 (PIK3CA)    05226 Gastric cancer     105806240 (PIK3CA)    05214 Glioma     105806240 (PIK3CA)    05221 Acute myeloid leukemia     105806240 (PIK3CA)    05220 Chronic myeloid leukemia     105806240 (PIK3CA)    05218 Melanoma     105806240 (PIK3CA)    05211 Renal cell carcinoma     105806240 (PIK3CA)    05215 Prostate cancer     105806240 (PIK3CA)    05213 Endometrial cancer     105806240 (PIK3CA)    05224 Breast cancer     105806240 (PIK3CA)    05222 Small cell lung cancer     105806240 (PIK3CA)    05223 Non-small cell lung cancer     105806240 (PIK3CA)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     105806240 (PIK3CA)    05170 Human immunodeficiency virus 1 infection     105806240 (PIK3CA)    05161 Hepatitis B     105806240 (PIK3CA)    05160 Hepatitis C     105806240 (PIK3CA)    05171 Coronavirus disease - COVID-19     105806240 (PIK3CA)    05164 Influenza A     105806240 (PIK3CA)    05162 Measles     105806240 (PIK3CA)    05163 Human cytomegalovirus infection     105806240 (PIK3CA)    05167 Kaposi sarcoma-associated herpesvirus infection     105806240 (PIK3CA)    05169 Epstein-Barr virus infection     105806240 (PIK3CA)    05165 Human papillomavirus infection     105806240 (PIK3CA)   09171 Infectious disease: bacterial    05135 Yersinia infection     105806240 (PIK3CA)    05100 Bacterial invasion of epithelial cells     105806240 (PIK3CA)   09174 Infectious disease: parasitic    05146 Amoebiasis     105806240 (PIK3CA)    05142 Chagas disease     105806240 (PIK3CA)   09164 Neurodegenerative disease    05010 Alzheimer disease     105806240 (PIK3CA)    05017 Spinocerebellar ataxia     105806240 (PIK3CA)    05020 Prion disease     105806240 (PIK3CA)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     105806240 (PIK3CA)    05418 Fluid shear stress and atherosclerosis     105806240 (PIK3CA)    05415 Diabetic cardiomyopathy     105806240 (PIK3CA)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     105806240 (PIK3CA)    04932 Non-alcoholic fatty liver disease     105806240 (PIK3CA)    04931 Insulin resistance     105806240 (PIK3CA)    04933 AGE-RAGE signaling pathway in diabetic complications     105806240 (PIK3CA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     105806240 (PIK3CA)    01524 Platinum drug resistance     105806240 (PIK3CA)    01522 Endocrine resistance     105806240 (PIK3CA)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:pcoq04131]     105806240 (PIK3CA) Enzymes [BR:pcoq01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      105806240 (PIK3CA) Membrane trafficking [BR:pcoq04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     105806240 (PIK3CA) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI3Ka PI3_PI4_kinase PI3K_p85B PI3K_C2 PI3K_rbd DUF2321 ABC1 Ribosomal_S15 Retrotran_gag_4 Motif Other DBs NCBI-GeneID:  105806240 NCBI-ProteinID:  XP_012494777 Ensembl:  ENSPCOG00000019539 LinkDB All DBs Position Unknown AA seq 970 aa AA seqDB search MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH IYNKLDKASPLNILQYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATP YMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRV PCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEVKYFRRNHYFYLXKLLLII LLNEIFHKMDETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLA RDNELRENDKEQLRAICTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRD EVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQV LKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMY LKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPA HQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIR IMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLH QWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFL DHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLF INLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWI FHTIKQHALN NT seq 2913 nt NT seq  +upstreamnt  +downstreamnt atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct actttaataactataaagcatgaactgtttaaagaagcaagaaaataccctctccatcaa cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa gaatttttcgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaagacttccga agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat agtagggcaatgtatgtttatcccccaaatgtagaatcttcaccagaactgccaaagcac atatataataaattagataaagcttctccccttaatatcttacagtatataaggagctgt ataatgcttgggaggatgcccaatttgatgctgatggctaaagaaagcctttactctcaa ctgccaatggactgttttacaatgccatcttattccagacgtatttccacagctacacca tatatgaatggagaaacatctacaaaatctctttgggttataaatagtgcactcagaata aaaattctttgtgcaacctatgtgaatgtaaatattcgagacattgataagatctatgtt cgaacaggcatctaccatggaggagaacccttatgtgacaatgtaaacactcagagagta ccttgttccaatcccagatggaatgaatggctgaattatgacatatacattcctgatctt cctcgtgctgctcgactctgcctttccatttgctctgttaaaggccgcaagggtgctaaa gaggtaaagtatttcagaaggaaccactacttttacctctaaaaacttttactaattata ctgctgaatgaaatttttcacaaaatggatgaaactccatgtttagagttggagtttgac tggttcagcagtgtggtaaagtttccagatatgtcagtgattgaagaacacgccaattgg tctgtgtcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagct agagacaatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagat cctctatctgaaattactgaacaagagaaagattttctgtggagccacagacactattgt gtaactatccctgaaattctacctaaattgctattgtctgttaaatggaattctagagat gaagtagcccagatgtactgcttggtgaaagactggcctccaatcaaacctgaacaggct atggagcttctagactgtaattatccagatcctatggttcgaggttttgctgttcgatgc ttggaaaagtatttaacagatgacaaactttctcagtacttaattcagctagtacaggtc ctaaaatatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattg actaatcaaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaa acagttagtcagaggtttggtctgctcttggagtcctattgtcgtgcatgtgggatgtat ttgaagcacctgaataggcaagttgaggcaatggaaaagctcattaacttaactgacatt ctcaaacaggagaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaa atgaggcgaccagatttcatggatgctctacagggctttctatctcctctaaaccctgct catcaactaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggcca ctgtggttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgag atcatctttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgc attatggaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttacggctgt ctgtcaatcggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatg cagattcagtgcaaaggcggcctcaaaggcgcattgcagttcaacagccacacactacat cagtggctaaaagacaagaataaaggagaaatatatgatgcagccattgacctgttcaca cgttcatgtgctggatattgtgtagctaccttcattttggggattggagatcgtcacaat agtaacatcatggtgaaagatgatggacaactgtttcatatagattttggacactttttg gatcacaagaagaaaaaatttggctataaacgagaacgggtgccctttgttttgacacaa gatttcttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgag aggtttcaggagatgtgttacaaggcttacctagctattcggcagcatgccaatctcttc ataaatcttttctcgatgatgcttggctctggaatgccagaactacaatcttttgatgac attgcatacatccgaaagactctagccttagataaaactgagcaagaggctttggaatat tttatgaaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatc ttccacacaattaagcagcatgcattgaactga

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