Rattus norvegicus (rat): 134484121 Help Entry 134484121         CDS       T01003                                  Name (RefSeq) LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism rno  Rattus norvegicus (rat) Pathway rno00562   Inositol phosphate metabolism rno01100   Metabolic pathways rno01521   EGFR tyrosine kinase inhibitor resistance rno01522   Endocrine resistance rno01524   Platinum drug resistance rno04012   ErbB signaling pathway rno04014   Ras signaling pathway rno04015   Rap1 signaling pathway rno04024   cAMP signaling pathway rno04062   Chemokine signaling pathway rno04066   HIF-1 signaling pathway rno04068   FoxO signaling pathway rno04070   Phosphatidylinositol signaling system rno04071   Sphingolipid signaling pathway rno04072   Phospholipase D signaling pathway rno04081   Hormone signaling rno04140   Autophagy - animal rno04150   mTOR signaling pathway rno04151   PI3K-Akt signaling pathway rno04152   AMPK signaling pathway rno04210   Apoptosis rno04211   Longevity regulating pathway rno04213   Longevity regulating pathway - multiple species rno04218   Cellular senescence rno04360   Axon guidance rno04370   VEGF signaling pathway rno04380   Osteoclast differentiation rno04510   Focal adhesion rno04550   Signaling pathways regulating pluripotency of stem cells rno04611   Platelet activation rno04613   Neutrophil extracellular trap formation rno04620   Toll-like receptor signaling pathway rno04625   C-type lectin receptor signaling pathway rno04630   JAK-STAT signaling pathway rno04650   Natural killer cell mediated cytotoxicity rno04660   T cell receptor signaling pathway rno04662   B cell receptor signaling pathway rno04664   Fc epsilon RI signaling pathway rno04666   Fc gamma R-mediated phagocytosis rno04668   TNF signaling pathway rno04670   Leukocyte transendothelial migration rno04722   Neurotrophin signaling pathway rno04725   Cholinergic synapse rno04750   Inflammatory mediator regulation of TRP channels rno04810   Regulation of actin cytoskeleton rno04910   Insulin signaling pathway rno04914   Progesterone-mediated oocyte maturation rno04915   Estrogen signaling pathway rno04917   Prolactin signaling pathway rno04919   Thyroid hormone signaling pathway rno04923   Regulation of lipolysis in adipocytes rno04926   Relaxin signaling pathway rno04929   GnRH secretion rno04930   Type II diabetes mellitus rno04931   Insulin resistance rno04932   Non-alcoholic fatty liver disease rno04933   AGE-RAGE signaling pathway in diabetic complications rno04935   Growth hormone synthesis, secretion and action rno04960   Aldosterone-regulated sodium reabsorption rno04973   Carbohydrate digestion and absorption rno05010   Alzheimer disease rno05017   Spinocerebellar ataxia rno05020   Prion disease rno05100   Bacterial invasion of epithelial cells rno05132   Salmonella infection rno05135   Yersinia infection rno05142   Chagas disease rno05146   Amoebiasis rno05160   Hepatitis C rno05161   Hepatitis B rno05162   Measles rno05163   Human cytomegalovirus infection rno05164   Influenza A rno05165   Human papillomavirus infection rno05166   Human T-cell leukemia virus 1 infection rno05167   Kaposi sarcoma-associated herpesvirus infection rno05168   Herpes simplex virus 1 infection rno05169   Epstein-Barr virus infection rno05170   Human immunodeficiency virus 1 infection rno05171   Coronavirus disease - COVID-19 rno05200   Pathways in cancer rno05203   Viral carcinogenesis rno05205   Proteoglycans in cancer rno05206   MicroRNAs in cancer rno05207   Chemical carcinogenesis - receptor activation rno05208   Chemical carcinogenesis - reactive oxygen species rno05210   Colorectal cancer rno05211   Renal cell carcinoma rno05212   Pancreatic cancer rno05213   Endometrial cancer rno05214   Glioma rno05215   Prostate cancer rno05218   Melanoma rno05220   Chronic myeloid leukemia rno05221   Acute myeloid leukemia rno05222   Small cell lung cancer rno05223   Non-small cell lung cancer rno05224   Breast cancer rno05225   Hepatocellular carcinoma rno05226   Gastric cancer rno05230   Central carbon metabolism in cancer rno05231   Choline metabolism in cancer rno05235   PD-L1 expression and PD-1 checkpoint pathway in cancer rno05415   Diabetic cardiomyopathy rno05417   Lipid and atherosclerosis rno05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:rno00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     134484121  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     134484121    04015 Rap1 signaling pathway     134484121    04630 JAK-STAT signaling pathway     134484121    04668 TNF signaling pathway     134484121    04066 HIF-1 signaling pathway     134484121    04068 FoxO signaling pathway     134484121    04070 Phosphatidylinositol signaling system     134484121    04072 Phospholipase D signaling pathway     134484121    04071 Sphingolipid signaling pathway     134484121    04024 cAMP signaling pathway     134484121    04151 PI3K-Akt signaling pathway     134484121    04152 AMPK signaling pathway     134484121    04150 mTOR signaling pathway     134484121   09133 Signaling molecules and interaction    04081 Hormone signaling     134484121  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     134484121   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     134484121  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     134484121    04613 Neutrophil extracellular trap formation     134484121    04620 Toll-like receptor signaling pathway     134484121    04650 Natural killer cell mediated cytotoxicity     134484121    04660 T cell receptor signaling pathway     134484121    04662 B cell receptor signaling pathway     134484121    04664 Fc epsilon RI signaling pathway     134484121    04666 Fc gamma R-mediated phagocytosis     134484121    04670 Leukocyte transendothelial migration     134484121    04062 Chemokine signaling pathway     134484121   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     134484121    04929 GnRH secretion     134484121    04915 Estrogen signaling pathway     134484121    04917 Prolactin signaling pathway     134484121    04926 Relaxin signaling pathway     134484121    04935 Growth hormone synthesis, secretion and action     134484121    04919 Thyroid hormone signaling pathway     134484121   09154 Digestive system    04973 Carbohydrate digestion and absorption     134484121   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     134484121   09156 Nervous system    04725 Cholinergic synapse     134484121    04722 Neurotrophin signaling pathway     134484121   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     134484121   09158 Development and regeneration    04360 Axon guidance     134484121    04380 Osteoclast differentiation     134484121   09149 Aging    04211 Longevity regulating pathway     134484121    04213 Longevity regulating pathway - multiple species     134484121  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     134484121    05206 MicroRNAs in cancer     134484121    05205 Proteoglycans in cancer     134484121    05207 Chemical carcinogenesis - receptor activation     134484121    05208 Chemical carcinogenesis - reactive oxygen species     134484121    05203 Viral carcinogenesis     134484121    05230 Central carbon metabolism in cancer     134484121    05231 Choline metabolism in cancer     134484121    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     134484121   09162 Cancer: specific types    05210 Colorectal cancer     134484121    05212 Pancreatic cancer     134484121    05225 Hepatocellular carcinoma     134484121    05226 Gastric cancer     134484121    05214 Glioma     134484121    05221 Acute myeloid leukemia     134484121    05220 Chronic myeloid leukemia     134484121    05218 Melanoma     134484121    05211 Renal cell carcinoma     134484121    05215 Prostate cancer     134484121    05213 Endometrial cancer     134484121    05224 Breast cancer     134484121    05222 Small cell lung cancer     134484121    05223 Non-small cell lung cancer     134484121   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     134484121    05170 Human immunodeficiency virus 1 infection     134484121    05161 Hepatitis B     134484121    05160 Hepatitis C     134484121    05171 Coronavirus disease - COVID-19     134484121    05164 Influenza A     134484121    05162 Measles     134484121    05163 Human cytomegalovirus infection     134484121    05167 Kaposi sarcoma-associated herpesvirus infection     134484121    05169 Epstein-Barr virus infection     134484121    05165 Human papillomavirus infection     134484121   09171 Infectious disease: bacterial    05135 Yersinia infection     134484121    05100 Bacterial invasion of epithelial cells     134484121   09174 Infectious disease: parasitic    05146 Amoebiasis     134484121    05142 Chagas disease     134484121   09164 Neurodegenerative disease    05010 Alzheimer disease     134484121    05017 Spinocerebellar ataxia     134484121    05020 Prion disease     134484121   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     134484121    05418 Fluid shear stress and atherosclerosis     134484121    05415 Diabetic cardiomyopathy     134484121   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     134484121    04932 Non-alcoholic fatty liver disease     134484121    04931 Insulin resistance     134484121    04933 AGE-RAGE signaling pathway in diabetic complications     134484121   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     134484121    01524 Platinum drug resistance     134484121    01522 Endocrine resistance     134484121  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:rno04131]     134484121 Enzymes [BR:rno01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      134484121 Membrane trafficking [BR:rno04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     134484121 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_p85B PI3K_rbd DUF2321 ABC1 Retrotran_gag_4 Motif Other DBs NCBI-GeneID:  134484121 NCBI-ProteinID:  XP_063136586 LinkDB All DBs Position X:complement(25064123..25121918) Genome browser AA seq 1107 aa AA seqDB search MISSNSQGPPNWQESLEEWRISSENTRSSQRVRTIPPRPSSGELWGIHLMPPRILVECLL PNGMIVTLECLREATLVTIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDET RRLCDLRLFQPFLKVIEPVGNREEKILNREIGFVIGMPVCEFDMVKDLEVQDFRXNILNV CKEAVGLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQK YTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYP LSQYKERRPLCEYIRSCIMLGRMPNLMLMAKESLHSQLPIDSFTMPSYSRRISTATPYMN GETATKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGESLCDNVNTQRVPCS NPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSG KMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWS VSREAGFSYSHTGLSNRLARDNELRENDKEQLXALCTRDPLSEITEQEKDFLWSHRHYCV TIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRSFAVRCL EKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKT VSQRFSLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQM RQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEI IFKNGDDLRQDMLTLXRIMENIWQNQGLDLRMLPYACLSIGDCVGLIEVVRNSHTIMQIQ CKGGLKGALQFNRHTLHQWLKDKNKGKIYDAAIDLFTWSCAGYCVATFILGIGDRHNSNI MVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQEYTKTREFERFQ EMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFTK QMNDAHHGGWTTKMDWIFHTIKQHALN NT seq 3324 nt NT seq  +upstreamnt  +downstreamnt atgatcagtagcaacagccagggtcctcccaactggcaggagtccctggaagaatggaga atcagcagtgagaatacaagaagttctcagagggtcagaacaattcctccacgaccatct tcgggtgaactgtggggcatccacttgatgcccccacgaatcctagtggaatgtttactc ccaaatggaatgatagtgactttagaatgcctccgtgaggccacactagtcaccatcaag catgaactgttcaaagaggccaggaaataccctctccatcagcttctgcaagatgaatca tcttacattttcgtaagtgttacccaagaagcagaaagggaagaatttttcgatgaaaca agacggctttgtgaccttcggctttttcaaccctttttaaaagtaattgagccagtaggc aaccgtgaagaaaagatcctcaaccgagaaattggttttgttattggcatgccagtgtgt gaatttgatatggttaaagatctagaagtccaagacttccganagaacattctgaatgtt tgcaaagaagccgtgggcctgcgggatctcaactcgcctcatagcagagcaatgtatgtc taccctccaaatgtcgagtcttccccagaactgccaaagcacatctacaacaagttagat aaaggacaaatcatagtggtgatttgggtgatagtctctccaaacaacgacaagcagaag tacactctgaagatcaaccatgactgcgtgccagagcaagtcattgctgaggccatcagg aagaagacccggagcatgttgctgtcctcggagcagctgaaactctgtgtcttagaatac cagggcaagtacattctcaaagtgtgtggctgtgatgagtacttcctagagaagtaccct ctgagtcagtacaaggagagaagacccttgtgcgaatacataagaagctgtataatgctg gggaggatgcccaacttgatgctgatggccaaggagagcctgcactctcagctgccgatc gatagcttcacaatgccatcctactccaggcgcatttccacagcgacaccctatatgaac ggggagactgctacgaaatctctctgggttataaatagcgcgctcagaataaaaattctg tgtgcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggt atctaccatggaggagaatccttatgtgacaatgtgaatactcaaagagtcccttgttcc aatcctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgct gcccgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcac tgtccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccggg aaaatggctttgaatctctggcctgtaccacatgggttggaagatctgctgaaccctatt ggtgttactgggtcaaatccaaataaagaaactccatgcttagagttggagtttgattgg ttcagcagtgtggtgaagtttccagatatgtctgtgatcgaagagcatgccaattggtct gtgtcccgagaagccggattcagttactctcatacaggactgagtaacagactagccaga gacaatgagttaagagaaaatgacaaggaacagctctgagcactttgtacccgggaccca ctgtctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgta actattcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaa gtggcccagatgtactgcttagtaaaagattggcctccaatcaaaccagagcaagccatg gagctcctggactgtaactacccagaccccatggttcggagctttgctgtccggtgcttg gaaaaatacttaacagatgacaaactttctcagtacctcatccagcttgtacaggtctta aaatatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcactgaca aatcaaaggattggccattttttcttttggcatttaaaatctgagatgcacaataagact gtcagtcagaggttcagcctgctgttggagtcctactgccgtgcctgtgggatgtatctg aagcacctgaacagacaggtagaggccatggagaagctcatcaatctaactgacatcctc aagcaagagaagaaggatgagacacagaaggtacagatgaagttcttggttgaacagatg agacagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcat caactaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactg tggttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatc atctttaaaaatggcgatgacttacggcaagacatgttaacccttnncagaatcatggag aacatctggcaaaaccaaggccttgaccttcgcatgctaccttatgcctgtctatccatt ggggactgtgtgggtctcatcgaggtggtgagaaactctcacaccatcatgcagattcag tgcaaaggaggcctgaagggggcactgcagttcaacaggcacacgctgcatcagtggctc aaggacaagaacaagggcaagatatatgacgcagccattgacctgttcacttggtcctgc gctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaacatc atggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcacaag aagaaaaaatttggctataaacgggaacgcgtgccgtttgttttgacgcaggatttctta atagtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggtttcag gagatgtgttacaaggcgtacctagcaattcggcagcatgccaatctcttcatcaacctt ttctccatgatgcttggctccggaatgccagaactgcagtcttttgatgatattgcatat attcgaaagactctagccttagacaaaactgagcaagaggctctggagtatttcacaaag caaatgaatgacgcacatcatggtggctggacaacaaaaatggactggatcttccacacc atcaagcagcatgcattgaactga

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