Vicugna pacos (alpaca): 102543068 Help Entry 102543068         CDS       T08098                                  Symbol PIK3CA Name (RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform   KO K00922   phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153] Organism vpc  Vicugna pacos (alpaca) Pathway vpc00562   Inositol phosphate metabolism vpc01100   Metabolic pathways vpc01521   EGFR tyrosine kinase inhibitor resistance vpc01522   Endocrine resistance vpc01524   Platinum drug resistance vpc04012   ErbB signaling pathway vpc04014   Ras signaling pathway vpc04015   Rap1 signaling pathway vpc04024   cAMP signaling pathway vpc04062   Chemokine signaling pathway vpc04066   HIF-1 signaling pathway vpc04068   FoxO signaling pathway vpc04070   Phosphatidylinositol signaling system vpc04071   Sphingolipid signaling pathway vpc04072   Phospholipase D signaling pathway vpc04081   Hormone signaling vpc04140   Autophagy - animal vpc04150   mTOR signaling pathway vpc04151   PI3K-Akt signaling pathway vpc04152   AMPK signaling pathway vpc04210   Apoptosis vpc04211   Longevity regulating pathway vpc04213   Longevity regulating pathway - multiple species vpc04218   Cellular senescence vpc04360   Axon guidance vpc04370   VEGF signaling pathway vpc04380   Osteoclast differentiation vpc04510   Focal adhesion vpc04550   Signaling pathways regulating pluripotency of stem cells vpc04611   Platelet activation vpc04613   Neutrophil extracellular trap formation vpc04620   Toll-like receptor signaling pathway vpc04625   C-type lectin receptor signaling pathway vpc04630   JAK-STAT signaling pathway vpc04650   Natural killer cell mediated cytotoxicity vpc04660   T cell receptor signaling pathway vpc04662   B cell receptor signaling pathway vpc04664   Fc epsilon RI signaling pathway vpc04666   Fc gamma R-mediated phagocytosis vpc04668   TNF signaling pathway vpc04670   Leukocyte transendothelial migration vpc04722   Neurotrophin signaling pathway vpc04725   Cholinergic synapse vpc04750   Inflammatory mediator regulation of TRP channels vpc04810   Regulation of actin cytoskeleton vpc04910   Insulin signaling pathway vpc04914   Progesterone-mediated oocyte maturation vpc04915   Estrogen signaling pathway vpc04917   Prolactin signaling pathway vpc04919   Thyroid hormone signaling pathway vpc04923   Regulation of lipolysis in adipocytes vpc04926   Relaxin signaling pathway vpc04929   GnRH secretion vpc04930   Type II diabetes mellitus vpc04931   Insulin resistance vpc04932   Non-alcoholic fatty liver disease vpc04933   AGE-RAGE signaling pathway in diabetic complications vpc04935   Growth hormone synthesis, secretion and action vpc04960   Aldosterone-regulated sodium reabsorption vpc04973   Carbohydrate digestion and absorption vpc05010   Alzheimer disease vpc05017   Spinocerebellar ataxia vpc05020   Prion disease vpc05100   Bacterial invasion of epithelial cells vpc05132   Salmonella infection vpc05135   Yersinia infection vpc05142   Chagas disease vpc05146   Amoebiasis vpc05160   Hepatitis C vpc05161   Hepatitis B vpc05162   Measles vpc05163   Human cytomegalovirus infection vpc05164   Influenza A vpc05165   Human papillomavirus infection vpc05166   Human T-cell leukemia virus 1 infection vpc05167   Kaposi sarcoma-associated herpesvirus infection vpc05168   Herpes simplex virus 1 infection vpc05169   Epstein-Barr virus infection vpc05170   Human immunodeficiency virus 1 infection vpc05171   Coronavirus disease - COVID-19 vpc05200   Pathways in cancer vpc05203   Viral carcinogenesis vpc05205   Proteoglycans in cancer vpc05206   MicroRNAs in cancer vpc05207   Chemical carcinogenesis - receptor activation vpc05208   Chemical carcinogenesis - reactive oxygen species vpc05210   Colorectal cancer vpc05211   Renal cell carcinoma vpc05212   Pancreatic cancer vpc05213   Endometrial cancer vpc05214   Glioma vpc05215   Prostate cancer vpc05218   Melanoma vpc05220   Chronic myeloid leukemia vpc05221   Acute myeloid leukemia vpc05222   Small cell lung cancer vpc05223   Non-small cell lung cancer vpc05224   Breast cancer vpc05225   Hepatocellular carcinoma vpc05226   Gastric cancer vpc05230   Central carbon metabolism in cancer vpc05231   Choline metabolism in cancer vpc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer vpc05415   Diabetic cardiomyopathy vpc05417   Lipid and atherosclerosis vpc05418   Fluid shear stress and atherosclerosis Brite KEGG Orthology (KO) [BR:vpc00001]  09100 Metabolism   09101 Carbohydrate metabolism    00562 Inositol phosphate metabolism     102543068 (PIK3CA)  09130 Environmental Information Processing   09132 Signal transduction    04014 Ras signaling pathway     102543068 (PIK3CA)    04015 Rap1 signaling pathway     102543068 (PIK3CA)    04630 JAK-STAT signaling pathway     102543068 (PIK3CA)    04668 TNF signaling pathway     102543068 (PIK3CA)    04066 HIF-1 signaling pathway     102543068 (PIK3CA)    04068 FoxO signaling pathway     102543068 (PIK3CA)    04070 Phosphatidylinositol signaling system     102543068 (PIK3CA)    04072 Phospholipase D signaling pathway     102543068 (PIK3CA)    04071 Sphingolipid signaling pathway     102543068 (PIK3CA)    04024 cAMP signaling pathway     102543068 (PIK3CA)    04151 PI3K-Akt signaling pathway     102543068 (PIK3CA)    04152 AMPK signaling pathway     102543068 (PIK3CA)    04150 mTOR signaling pathway     102543068 (PIK3CA)   09133 Signaling molecules and interaction    04081 Hormone signaling     102543068 (PIK3CA)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     102543068 (PIK3CA)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102543068 (PIK3CA)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102543068 (PIK3CA)    04613 Neutrophil extracellular trap formation     102543068 (PIK3CA)    04620 Toll-like receptor signaling pathway     102543068 (PIK3CA)    04650 Natural killer cell mediated cytotoxicity     102543068 (PIK3CA)    04660 T cell receptor signaling pathway     102543068 (PIK3CA)    04662 B cell receptor signaling pathway     102543068 (PIK3CA)    04664 Fc epsilon RI signaling pathway     102543068 (PIK3CA)    04666 Fc gamma R-mediated phagocytosis     102543068 (PIK3CA)    04670 Leukocyte transendothelial migration     102543068 (PIK3CA)    04062 Chemokine signaling pathway     102543068 (PIK3CA)   09152 Endocrine system    04923 Regulation of lipolysis in adipocytes     102543068 (PIK3CA)    04929 GnRH secretion     102543068 (PIK3CA)    04915 Estrogen signaling pathway     102543068 (PIK3CA)    04917 Prolactin signaling pathway     102543068 (PIK3CA)    04926 Relaxin signaling pathway     102543068 (PIK3CA)    04935 Growth hormone synthesis, secretion and action     102543068 (PIK3CA)    04919 Thyroid hormone signaling pathway     102543068 (PIK3CA)   09154 Digestive system    04973 Carbohydrate digestion and absorption     102543068 (PIK3CA)   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     102543068 (PIK3CA)   09156 Nervous system    04725 Cholinergic synapse     102543068 (PIK3CA)    04722 Neurotrophin signaling pathway     102543068 (PIK3CA)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     102543068 (PIK3CA)   09158 Development and regeneration    04360 Axon guidance     102543068 (PIK3CA)    04380 Osteoclast differentiation     102543068 (PIK3CA)   09149 Aging    04211 Longevity regulating pathway     102543068 (PIK3CA)    04213 Longevity regulating pathway - multiple species     102543068 (PIK3CA)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102543068 (PIK3CA)    05206 MicroRNAs in cancer     102543068 (PIK3CA)    05205 Proteoglycans in cancer     102543068 (PIK3CA)    05207 Chemical carcinogenesis - receptor activation     102543068 (PIK3CA)    05208 Chemical carcinogenesis - reactive oxygen species     102543068 (PIK3CA)    05203 Viral carcinogenesis     102543068 (PIK3CA)    05230 Central carbon metabolism in cancer     102543068 (PIK3CA)    05231 Choline metabolism in cancer     102543068 (PIK3CA)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102543068 (PIK3CA)   09162 Cancer: specific types    05210 Colorectal cancer     102543068 (PIK3CA)    05212 Pancreatic cancer     102543068 (PIK3CA)    05225 Hepatocellular carcinoma     102543068 (PIK3CA)    05226 Gastric cancer     102543068 (PIK3CA)    05214 Glioma     102543068 (PIK3CA)    05221 Acute myeloid leukemia     102543068 (PIK3CA)    05220 Chronic myeloid leukemia     102543068 (PIK3CA)    05218 Melanoma     102543068 (PIK3CA)    05211 Renal cell carcinoma     102543068 (PIK3CA)    05215 Prostate cancer     102543068 (PIK3CA)    05213 Endometrial cancer     102543068 (PIK3CA)    05224 Breast cancer     102543068 (PIK3CA)    05222 Small cell lung cancer     102543068 (PIK3CA)    05223 Non-small cell lung cancer     102543068 (PIK3CA)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102543068 (PIK3CA)    05170 Human immunodeficiency virus 1 infection     102543068 (PIK3CA)    05161 Hepatitis B     102543068 (PIK3CA)    05160 Hepatitis C     102543068 (PIK3CA)    05171 Coronavirus disease - COVID-19     102543068 (PIK3CA)    05164 Influenza A     102543068 (PIK3CA)    05162 Measles     102543068 (PIK3CA)    05163 Human cytomegalovirus infection     102543068 (PIK3CA)    05167 Kaposi sarcoma-associated herpesvirus infection     102543068 (PIK3CA)    05169 Epstein-Barr virus infection     102543068 (PIK3CA)    05165 Human papillomavirus infection     102543068 (PIK3CA)   09171 Infectious disease: bacterial    05135 Yersinia infection     102543068 (PIK3CA)    05100 Bacterial invasion of epithelial cells     102543068 (PIK3CA)   09174 Infectious disease: parasitic    05146 Amoebiasis     102543068 (PIK3CA)    05142 Chagas disease     102543068 (PIK3CA)   09164 Neurodegenerative disease    05010 Alzheimer disease     102543068 (PIK3CA)    05017 Spinocerebellar ataxia     102543068 (PIK3CA)    05020 Prion disease     102543068 (PIK3CA)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     102543068 (PIK3CA)    05418 Fluid shear stress and atherosclerosis     102543068 (PIK3CA)    05415 Diabetic cardiomyopathy     102543068 (PIK3CA)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     102543068 (PIK3CA)    04932 Non-alcoholic fatty liver disease     102543068 (PIK3CA)    04931 Insulin resistance     102543068 (PIK3CA)    04933 AGE-RAGE signaling pathway in diabetic complications     102543068 (PIK3CA)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102543068 (PIK3CA)    01524 Platinum drug resistance     102543068 (PIK3CA)    01522 Endocrine resistance     102543068 (PIK3CA)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    04131 Membrane trafficking [BR:vpc04131]     102543068 (PIK3CA) Enzymes [BR:vpc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.1  Phosphotransferases with an alcohol group as acceptor     2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase      102543068 (PIK3CA) Membrane trafficking [BR:vpc04131]  Endocytosis   Rab GTPases and associated proteins    Rab associated proteins     102543068 (PIK3CA) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15 Motif Other DBs NCBI-GeneID:  102543068 NCBI-ProteinID:  XP_006210673 UniProt:  A0A6I9IFN7 LinkDB All DBs Position 1 AA seq 1068 aa AA seqDB search MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct acattaataactataaagcatgaactatttaaagaagcaagaaaataccctctccatcaa cttcttcaagatgaatcttcttacatttttgtaagtgttacccaagaagcagaaagggaa gaattttttgatgaaacaagacgactttgtgaccttcgactttttcaaccctttttaaaa gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct atcggcatgccagtatgtgaatttgatatggttaaagatccagaagtacaggacttccga agaaatattctgaatgtttgtaaagaagctgtggatcttagggatcttaattcacctcat agtagagcaatgtatgtctatcctccaaacgtagaatcttcaccagaactgccaaagcac atatataataaattggataaagggcaaataatagtggtgatttgggtcatagtttctcca aataatgacaaacaaaagtatactctgaaaatcaaccacgactgtgtgccagaacaagta attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa ctctgtgttttagaataccagggcaagtatatattaaaagtgtgtggatgtgacgaatac ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg aggatgcccaatctgatgctgatggctaaagaaagcctctactctcaactgccaatggac tgttttacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga gagacatctacaaaatccctttgggttataaatagtgctctcagaataaaaattctttgt gcaacctatgtgaatgtaaatattcgagacattgacaagatctatgttcgaacaggtatc taccatggaggggaacccttatgtgataatgtgaacactcaaagagtaccttgttccaat cccagatggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt ccattggcctggggaaatataaacttgtttgattacacagatactcttgtatctggaaaa atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt gttactgggtcaaatccaaataaagaaactccttgcttagagttggagtttgactggttc agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgccaattggtctgta tcccgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacacgagatcctcta tctgaaatcactgagcaggagaaggattttctgtggagccacaggcactattgtgtaact attcctgaaattctacccaaattgcttctgtctgtcaaatggaattctagagatgaagta gctcagatgtattgcttggtaaaagactggcctccaatcaaacctgaacaggctatggag cttctggactgcaattacccagatcctatggttcgaagttttgctgttagatgtttggaa aaatatttaacagatgacaaactttctcagtacctaattcagctagtacaggtcctaaaa tatgaacagtatttggataacctgcttgtgagatttttactcaaaaaagcattgactaat caaaggatcgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt agtcagaggtttggcctgcttttggagtcctattgccgtgcatgtgggatgtatttgaag cacttgaataggcaagttgaggcgatggaaaagctcattaacttaactgacattctcaaa caagagaaaaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg cgaccagatttcatggatgctctacagggctttctgtcccctctaaaccctgctcatcaa ctgggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactctgg ttgaattgggagaacccagacatcatgtcagaattactctttcagaacaatgagatcatc tttaaaaatggggatgatttacggcaagatatgctaacacttcagattattcgcattatg gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca attggtgactgtgtgggacttattgaggtggtgagaaattctcacactattatgcaaatt cagtgcaaaggcggcctaaaaggtgcactgcagttcaacagccacacactacatcagtgg ctcaaagacaagaacaagggagaaatatatgatgcagccattgatctttttacacgttcg tgtgctggatattgtgttgctactttcattttgggaattggagatcgtcacaatagtaac atcatggttaaagatgatggacaattgtttcatatagattttggacactttctggatcac aagaagaaaaaatttggttataaacgagagcgtgtaccatttgttttgacacaagatttc ttaatagtgattagtaaaggagcccaggaatgcacaaagacaagagaatttgaaaggttt caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgatattgca tatattcgaaagaccctagctttagataaaactgagcaagaggctttggaatatttcatg aaacaaatgaatgatgcacaccatggtggctggacaacaaaaatggattggatcttccac acaattaaacagcatgctttgaactga

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