During the pathogenesis of Parkinson’s disease (PD), α-synuclein pathology may originate in peripheral organs and spread to the CNS. Using human tissue samples and multiple approaches in mouse models of renal failure, we demonstrated that the kidney serves as an origin of pathological α-synuclein in PD.
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References
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This is a summary of: Yuan, X. et al. Propagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson’s disease. Nat. Neurosci. https://doi.org/10.1038/s41593-024-01866-2 (2025).
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α-Synuclein deposition in the kidney may contribute to Parkinson’s disease. Nat Neurosci 28, 434–435 (2025). https://doi.org/10.1038/s41593-024-01867-1
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DOI: https://doi.org/10.1038/s41593-024-01867-1
