Changes in blood–brain barrier (BBB) properties and endocannabinoid system function contribute to stress responses and have been implicated in the development of mood disorders. Here, we report a mechanism linking both systems, in which neurovascular endocannabinoids prevented loss of BBB integrity induced by stress-related inflammation, resulting in stress resilience.
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References
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This is a summary of: Dudek, K. A. et al. Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations. Nat. Neurosci. https://doi.org/10.1038/s41593-025-01891-9 (2025).
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Endocannabinoid protection of the brain vasculature leads to stress resilience. Nat Neurosci (2025). https://doi.org/10.1038/s41593-025-01892-8
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DOI: https://doi.org/10.1038/s41593-025-01892-8
