Mapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. Correlations between mitochondrial and brain-imaging metrics could enable future non-invasive explorations of mitochondrial bioenergetics in the brain in health and disease.

Activated brown adipose tissue takes up large amounts of branched-chain amino acids (BCAAs), but their fate remains unclear. We provide evidence of a metabolic link between BCAA catabolism and haem biosynthesis, which supports mitochondrial function and regulates gene expression by influencing the epigenetic landscape of brown adipocytes.

Glutamatergic medial vestibular nuclei parvocellular part (MVePC^Glu) neurons have a dominant role in motion-induced hypothermia — a physiological correlate of motion sickness — via their downstream targets in the lateral parabrachial nucleus, and inhibition of this neural circuit alleviated motion-induced hypothermia in mice. Chronic inhibition of MVePC^Glu neurons also prevented diet-induced obesity by increasing energy expenditure.

A single-cell transcriptomic profile of oligodendrocyte precursor cells in the brain across the mouse lifespan reveals aging-associated changes that contribute to the decline of oligodendrogenesis in the aged central nervous system.

Although ovarian reserve remains sufficient, ovarian function declines in mid-age, leading to reduced fertility around age 35, with the causes remaining unclear. Recent studies highlight vascular aging as a key factor in this decline, with age-related reductions in ovarian vascular remodeling disrupting oocyte development. Salidroside, a natural compound that reverses ovarian vascular aging and promotes ovarian angiogenesis, presents a promising strategy to rejuvenate ovarian health and enhance fertility, offering potential for preserving reproductive function in aged women.

Data from 300,000 births reveal how essential biological measurements are altered by carrying and delivering a baby.

Mapping the density, molecular features and energy-transformation capacity of cell organelles called mitochondria in the brain reveals region- and cell-type-specific variability that tracks with evolutionary patterns. Correlations between mitochondrial and brain-imaging metrics could enable future non-invasive explorations of mitochondrial bioenergetics in the brain in health and disease.

Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

Activated brown adipose tissue takes up large amounts of branched-chain amino acids (BCAAs), but their fate remains unclear. We provide evidence of a metabolic link between BCAA catabolism and haem biosynthesis, which supports mitochondrial function and regulates gene expression by influencing the epigenetic landscape of brown adipocytes.