1. You are required to produce 20 powders each weighing 200 mg and containing 3 mg of drug X. Drug X is available as 30 mg tablets.

Which of the following would you require?

A
B C D E

One tablet made up to 2.0 g with lactose Two tablets made up to 4.0 g with lactose Two tablets made up to 2.0 g with lactose Four tablets made up to 4.0 g with lactose Two tablets made up to 8.0 g with lactose

2. You are required to prepare 10 powders each weighing 200mg and containing 5mg of a drug. The only form of the drug that is available is 30mg tablets. You will require: A Two tablets made up to 1.2g with lactose
B C D E 3. Two tablets made up to 2.0g with lactose Two tablets made up to 2.4g with lactose Two tablets made up to 3.0g with lactose One tablet made up to 2.4g with lactose You are required to produce 30 powders each weighing 100mg and containing 5mg of drug. The drug is available as 15mg tablets. Which of the following would you require? 5 tablets made up to 30 gram with lactose 10 tablets made up to 3 gram with lactose 20 tablets made up to 4.5 gram with lactose 10 tablets made up to 6 gram with lactose 15 tablets made up to 3 gram with lactose

A B C D E

4. You receive a prescription for captopril 3.125 mg qds for 30 days. The lowest strength preparation of captopril available to you is 12.5 mg tablets, each weighing 75 mg, so after discussion with the prescriber you decide to supply 200 mg powders each containing 3.125 mg of captopril using lactose as a diluent. What weight of lactose in grams needs to be added to the tablets to supply the exact amount required on the prescription? A B C D E 3.75 21.75 22.8 23.625 24.75

5. A manufacturer wishes to produce a batch of compressed tablets each containing 600 mg of active substance and with a mean tablet weight of 700 mg. What weight of active substance will be required for a total batch size of 420 kg? A B C D E 490 kg 400 kg 380 kg 360 kg 265 kg

6. You are required to prepare 10 powders each weighing 300mg and containing 10mg of a drug. The only form of the drug that is available is a 30mg tablet. You will require: A Two tablets made up to 1.2g with lactose
B C D E Two tablets made up to 2.0g with lactose Three tablets made up to 3.0g with lactose Three tablets made up to 2.7g with lactose Four tablets made up to 3.6g with lactose

7. You are required to prepare 10 powders each weighing 200mg and containing 5mg of a drug. The only form of the drug that is available is 30mg tablets. You will require: A Two tablets made up to 1.2g with lactose
B C D E Two tablets made up to 2.0g with lactose Two tablets made up to 2.4g with lactose Two tablets made up to 3.0g with lactose One tablet made up to 2.4g with lactose

8. You receive a prescription for indometacin 5 mg qds for 30 days. The lowest strength preparation of indometacin available to you is 25 mg tablets each weighing 75 mg, so after discussion with the prescriber you decide to supply 200 mg powders each containing 5 mg of indometacin using lactose as a diluent. What weight of lactose in grams needs to be added to the tablets to supply the exact amount required on the prescription? A= B C D E 22.2 12 1.8 24 25.8

9. You receive a prescription for spironolactone 5 mg daily for 30 days. The lowest strength preparation of spironolactone available to you is 25 mg

tablets, each weighing 90 mg, so after discussion with the prescriber you decide to supply 200 mg powders each containing 5 mg of spironolactone using lactose as a diluent. What number of tablets and weight of lactose in grams need to be mixed to supply the exact amount required on the prescription? A B C D E 1 2 3 4 5 6 7 8 9 B C B B D E C A D 3 tablets with 5.73 g lactose 3 tablets with 2.73 g lactose 4 tablets with 2.66 g lactose 6 tablets with 5.46 g lactose 6 tablets with 5.4 g lactose

1. A child is prescribed Floxapen elixir (125mg/5ml), 175mg every 6 hours for 9 days. Each bottle consists of 100mls. How many whole bottles of syrup need to be dispensed?

A1
B C D E 1.5 2 2.5 3

2. How much anhydrous sodium chloride is there in grams in 250ml of sodium chloride 1.8% intravenous infusion? A B C D E 3.6 4.5 18.0 36.0 45.0

3. A syringe driver is designed to contain 5ml of injection and a length of 60mm. Injection Y contains 4mg/ml. If a patient requires 2.5mg of drug Y per hour, at what rate setting in mm/hour should the syringe driver be fixed?

A
B C D E

7.5 3.75 12.0 6.0 7.2

4. A patient weighing 75.5 kg has been prescribed normal immunoglobulin 0.4g/kg IV daily by continuous infusion for 5 days for the treatment of idiopathic thrombocytopenic purpura. How many bottles need to be supplied for the whole course? Normal immunoglobulin is available as 1g, 3g and 6g vials

A
B C D E

(25 x 6g) + (1 x 3g) (25 x 6g) + (1 x 1g) (23 x 6g) + (3 x 3g) (23 x 6g) + (1 x 1g) (25 x 6g) + (1 x 3g) + (1 x 1g)

5. What weight of white soft paraffin is required to make 750g of the following product? Zinc oxide Salicylic acid Starch White soft paraffin 12% 1% 15% 100%

to 210 g 300 g 450 g 540 g 600 g

A
B C D E

6. A tablet labelled to contain 175 mg of active ingredient has acceptable limits of 90 to 110% of that amount. Which one of the following indicates the limits of content?

A
B C D

150 to 200 mg 155 to 195 mg 157.5 to 192.5mg 160 to 190 mg

170 to 180 mg

7. A 10 ml syringe in a syringe driver is used to administer diamorphine hydrochloride s/c at 5 mg per hour. The driver causes 0.5 ml of injection to be delivered per hour. How much diamorphine hydrochloride is needed in 10 ml of injection?

A
B C D E

150 mg 10 mg 1000mg 50 mg 100 mg

8. How much potassium permanganate would be needed in order to prepare 200 ml of a 1 in 500 solution?

A
B C D E

200 mg 400 mg 500 mg 1,000 mg 4,000 mg

9. You are required to produce 20 powders each weighing 200 mg and containing 3 mg of drug X. Drug X is available as 30 mg tablets. Which of the following would you require?

A
B C D E

One tablet made up to 2.0 g with lactose Two tablets made up to 4.0 g with lactose Two tablets made up to 2.0 g with lactose Four tablets made up to 4.0 g with lactose Two tablets made up to 8.0 g with lactose

10. You are required to provide 400 ml of an aqueous solution of chlorhexidine gluconate which, when diluted 1 in 10, produces a 1 in 1000 solution. You have available a stock solution of chlorhexidine gluconate 20% w/v. How much of the 20% solution would you make up to 400 ml with water to provide the aqueous dispensed solution, for further dilution by the patient? 4 ml B 8 ml C 20 ml D 40 ml E 80 ml 11. A patient is admitted to hospital following an overdose of drug X. Drug Xs half-life is 4.5 hours. The plasma level of X is found to be 48 microgram per ml, and this is toxic. How long, in hours, will it take for the plasma concentration to fall to the safe level of 3 microgram per ml? (You can assume

that the absorption and distribution is complete, and the elimination is described by a first order process.)

A
B C D E

9 36 13.5 18 22.5

12. An antibiotic is available as vials containing 800 mg powder. This should be reconstituted with 1.4 ml water for injections immediately before use, producing 2.0 ml of injection solution. A 5 year old girl is prescribed a 300 mg dose. What volume of injection solution contains this amount?

A
B C D E

0.3 ml 0.6 ml 1.2 ml 0.75 ml 1.5 ml

13. A pharmacist is asked to prepare a 150 ml sterile infusion of drug Y containing 16 micrograms per ml; he needs to make 153 ml of infusion to allow for overage. He has a concentrated solution for making the infusion that contains 80 micrograms of drug Y per ml and water for injections. The volume of concentrate required is?

A
B C D E

30.0 ml 30.2 ml 30.4 ml 30.6 ml 30.8 ml

14. A lady has been maintained on a dose of 300mg phenytoin at night for the last year. She is now unable to swallow tablets. What volume in mls of phenytoin suspension 30mg in 5ml has equivalent activity? A 25 B 33.3 C 30 D 45 E 50 15. A 14 year old boy is on holiday for 2 weeks in an endemic malaria area where proguanil is the recommended anti-malarial. How many 100 mg

proguanil hydrochloride tablets would be the minimum necessary for prophylactic cover?

A
B C D E

28 49 70 98 112

16. Which one of the following contains approximately the same amount of elemental iron as one ferrous sulphate 200 mg tablet three times a day?

A
B C D E

Feospan, two capsules daily Ferrous gluconate tablets 300 mg four times a day Fersamel, one tablet three times a day Slow-Fe tablets, two daily Sytron Elixir 7.5 ml three times a day

17. A patient is newly prescribed amiodarone at a dose of 200 mg tds for one week, then 200 mg bd for one week, and then 200 mg daily. How many 200 mg tablets would you provide for a total of 4 weeks supply?

A
B C D E

28 56 42 49 63

18. How many drops of One-Alpha oral drops are equivalent to one brown One-Alpha capsule?

A
B C D E

1 5 10 15 20

A
B C D E

If 1,2 and 3 are correct If 1 and 2 only are correct If 2 and 3 only are correct If 1 only is correct If 3 only is correct

19. A two-year old boy weighing 13 kg is to be treated with intramuscular pethidine hydrochloride to relieve pain. Which of the following doses fall within BNF recommended limits? 1 2 3 0.8 ml of a 10 mg per ml injection 0.3 ml of a 50 mg per ml injection 0.6 ml of a 50 mg per ml injection

20. A pharmacist has been asked to prepare three suspensions involving crushing tablets and making them up to volume with suspending vehicle. Which of the following is (are) correct formula(e)? 1 2 3 50 ml of chlorthiazide suspension 20 mg per ml: crush 2 x 500 mg tablets and make up to 50 ml with suspending base 300 ml of fenozime 5 mg in 5 ml: crush 30 x 10 mg tablets and make up to 300 ml with suspending base 50 ml of amiodarone suspension 100 mg in 5 ml: crush 10 x 200 mg tablets and make up to 50 ml with suspending base

A
B C D E Answers to Calculations test April 03

2 3 4 5 6 7 8 9 10 11 12 13 14 15

1E B A B D C E B B C D D D D D

16 17 18 19 20

C D C B B

1. The required dose of dopamine hydrochloride by intravenous infusion is 5mcg/kg/min. Dopamine intravenous solution contains 1.6mg per ml in 5% glucose in a 250ml bag. For a 64kg adult what volume per minute should the infusion be set at?

A
B C D E

5.0ml 0.5ml
2.5ml 2.0ml 0.2ml

2. A patient is admitted to hospital following an overdose of drug A. The drugs t1/2 (half life) is 8.5 hours. A toxic plasma concentration of 52 micrograms/ml is measured. How long in hours will it take for the plasma concentration to fall to 3.25 micrograms/ml?
You may assume that the absorption and destruction is complete and the elimination is described by a 1st order process.

A 24
B C D E 34 48 40 36

3. You are required to prepare 10 powders each weighing 300mg and containing 10mg of a drug. The only form of the drug that is available is a 30mg tablet. You will require: A Two tablets made up to 1.2g with lactose
B C D E Two tablets made up to 2.0g with lactose Three tablets made up to 3.0g with lactose Three tablets made up to 2.7g with lactose Four tablets made up to 3.6g with lactose

4. A potassium permanganate solution is to be diluted 10 times to a 0.01% solution. We have a stock solution of 16% potassium permanganate. How many ml of this stock solution need to be added to water to make 400ml of original solution to be diluted?

A
B C D E 5.

25ml + 375ml water 2.5ml + 397.5ml water 0.4ml + 399.6ml water 4ml + 396ml water 5ml + 395ml water

What quantity of potassium chloride is required to prepare 2.5 litres of a solution containing 1mml per ml? Molecular weight = 74.5

A 372.5mg
B C D E 186.25g 745mg 18.625g 74.5g

6. You have been asked to prepare a solution from a commercially available concentrate, which contains 50% of a salt. Calculate how much of the concentrate you need to prepare 300ml of a 10% solution.

A 75ml
B C D E 60ml 30ml 200ml 20ml

7. A patient self-administers Human Mixtard 30 insulin using a 3ml disposable pen. He is prescribed a dose of 24 units in the morning and 18 units in the evening. How many syringes do you need to supply for 60 days treatment? A B C D E 1 5 7 9 11

8. A doctor has prescribed 25g of an ointment containing 0.3% substance X, diluted with white soft paraffin. The only ointment available contains 1% of X. How much of this, in grams, do you need to weigh? A B 6.25 7.5

C D E

10 12.5 33

9. A patient is prescribed Venlafaxine 75mg daily for 7 days, increasing by 75mg daily every week until a maximum daily dose of 375mg. A total of 6 weeks treatment must be dispensed. How many 75mg tablets do you dispense? A B C D E 147 105 115 140 175

10. Adrenaline injection 1 in 1000 in 0.5ml ampoules contains the following amount of adrenaline in milligrams per ampoule? A B C D E 0.5 1.0 5.0 1.5 0.05

11. What is the equivalent dose of Oromorph 10mg every 4 hours to Diamorphine HCI by SC infusion over 24 hours? A
B C D E 15mg 22mg 20mg 30mg 5mg

12. A 5-year-old child is prescribed Ventolin Syrup. The dose is 1mg Salbutamol tds. How many ml of Ventolin Syrup have to be dispensed to give the patient a four-week supply?

A
B C D E 13. Statement 1

280ml 210ml 140ml 105ml 420ml

500ml of 6.3% Calcium Chloride solution for parenteral use provides 428.4 mmol of Chloride-ions and 214.2mmol of Calcium-ions.

Statement 2 2mg of Chloride-ions weigh more than 1 mg of Calcium-ions Decide whether:

A
B C D E

Statement 1 is true AND statement 2 is false Statement 1 is false AND statement 2 is false Statement 1 is false AND statement 2 is true Statement 1 is true AND statement 2 is true and Statement 2 explains Statement 1 Statement 1 is true AND statement 2 is true and Statement 2 does not explain statement 1

14. An elderly lady has been prescribed Gaviscon liquid, 10 ml qds. You
have been asked to calculate how many mmol of sodium ions she will receive each day from this. Which of the following is correct? A B C D E 18.4 20 24 30 40

15. A 55 year old lady has a body surface area of 1.60m. She has been diagnosed with primary ovarian cancer, and has been prescribed Taxol 175mg/m. When making up the Taxol intravenous infusion, what volume of Taxol Concentrate (in mls) should you use? A 4.67 B 5.25 C 32.5 D 46.7 E 52.5 16. A girl has been maintained on a dose of 200mg phenytoin at night for the last year. She is unable to swallow tablets. What volume in mls of phenytoin suspension 30mg in 5ml has equivalent activity? A B C D E 25 33.3 30 45 35

17. A male patient weighing 85Kg presents in A&E with a DVT. He is prescribed a 6 day course of s/c tinzaparin. How many 40,000units per 2ml vials would you supply? A B 3 4

C D E

5 7 9

18. You have to make 350g of Coal Tar Paste B.P. What weight of Strong Coal Tar Solution in g do you need to weigh out? A B C D E 35 26.25 25 52.5 13.13

19. How much Hydrogen Peroxide 100 volume solution would you need to make 300ml of 6% solution? A B C D E 30ml 60ml 90ml 18ml 36ml

20. A patient has been taking Calcium Gluconate 600mg tablets at a dose of 2 tablets three times a day. She is unable to swallow tablets and so you recommend a change to Calcium Sandoz syrup. What is the total daily dose of syrup in ml? A B C D E 10 15 20 25 30

Questions 1 to 4 concern the following oral doses: A B C D E 25mg four times a day 30mg three times a day 100mg three times a day 100mg four times a day 125mg four times a day

1. Ibuprofen to treat pain in a child weighing 15Kg at a dose of 20mg/Kg per day. Answer A B C D E

2. Paracetamol to treat pain in a jaundiced 8 week child weighing 5Kg. Answer A B C D E 3. Flucloxacillin to treat a staphylococcal infection in a 6 year old child. Answer A B C D E 4. Phenobarbitone to control epilepsy in a 12Kg child. Answer A B C D E 5. A girl has been maintained on a dose of 200mg phenytoin at night for the last year. She is unable to swallow tablets. What volume in mls of phenytoin suspension 30mg in 5ml has equivalent activity? A B C D E 25 33.3 30 45 35

6. A male patient weighing 85Kg presents in A and E with a DVT. He is prescribed a 6 day course of s/c tinzaparin. How many 40,000units per 2ml vials would you supply? A B C D E 3 4 5 7 9

7. You have to make 350g of Coal Tar Paste B.P.. What weight of Strong Coal Tar Solution in g do you need to weigh out? A B C D E 35 26.25 25 52.5 13.13

8. A 9 year old boy has severe psoriasis on his body and scalp. His mother applies Dovonex Scalp Solution twice a day and uses 30ml a week. What is the maximum amount of Dovonex Ointment in g that he can apply to his body each week? A B C D E 10 20 30 40 50

9. You are asked to make 75g of Whitfields (Compound Benzoic Acid) ointment. How much Emulsifying Ointment do you need to weigh? A B C D E 34.3g 91g 68.25g 70g 9g

10. How much Hydrogen Peroxide 100 volume solution would you need to make 300ml of 6% solution? A B C D E 30ml 60ml 90ml 18ml 36ml

11. patient is taking 2 Kapake tablets three times a day for pain and has a dry cough. How many 5ml doses of Codeine Linctus can he take, ensuring that he doesnt take more than the maximum daily dose of Codeine? A B C D E 2 3 4 5 6

12. A patient has been taking Calcium Gluconate 600mg tablets at a dose of 2 tablets three times a day. She is unable to swallow tablets and so you

recommend a change to Calcium Sandoz syrup. What is the total daily dose of syrup in ml? A B C D E 10 15 20 25 30

13. How much Chlorhexidine 5% concentrate do you require to make 250ml of a 0.1% solution?

A B C D E

5ml 10ml 50ml 2.5ml 0.25ml

14. A patient self-administers Human Mixtard 30 insulin using a 3ml disposable pen. He is prescribed a dose of 24 units in the morning and 18 units in the evening. How many syringes do you need to supply for 60 days treatment? A B C D E 1 5 7 9 11

15. A doctor has prescribed 25g of an ointment containing 0.3% substance X, diluted with white soft paraffin. The only ointment available contains 1% of X. How much of this, in grams, do you need to weigh? A B C D E 16. 6.25 7.5 10 12.5 33 A man weighing 60Kg is prescribed Dopamine 2.5microgram/Kg/min by the IV route. In this hospital Dopamine is usually administered at 4mg/ml. At what rate in ml/hour would you set the pump?

A B C D E

3 1.13 2.25 4.5 6

17. A child is prescribed salbutamol oral solution (2mg in 5ml) at a dose of 3mg tds for one week. What volume in ml would you dispense? A B C D E 105 157.5 210 225 362.5

18. A patient is prescribed a new treatment for 30 days supply of amiodarone, including the standard loading dose. How many 200mg tablets would you supply? A B C D E 30 42 51 49 90

19. How many grams of sodium chloride are there in 250ml of an infusion of sodium chloride 1.8% w/v? A B C D E 1.8 2.7 4.5 27 45

20. Which one of the following is the amount of solid ingredient in 150ml of 1.5% w/v solution? A B C D 1.5g 2.75g 2.25g 0.75g

E
1.

2.5g
What weight of potassium permanganate is required to prepare 250 mL of a solution such that 10 mL diluted to 1 litre will give a 1 in 10,000 solution? A B C D E 2.5 g 10 g 25 g 100 g 250 g

2.

A child weighing 22 lb is prescribed spironolactone oral suspension at a dose of 3 mg/kg daily in divided doses. Which one of the following provides the correct dose? A B C D E spironlacatone 5 mg/5 mL10 mL bd spironolactone 5 mg/5 mL 20 mL bd spironolactone 10 mg/5 mL 7.5 mL bd spironolactone 10 mg/5 mL 15 mL bd spironolactone 25 mg/5 mL 6.5 mL bd

3.

What volume of a stock solution of alcohol 96% v/v is required to prepare 3 litres of alcohol 80% v / v? A B C D E 2480 mL 2500 mL 2600 mL 2750 mL 2880 mL

4.

A child weighing 6.6 kg is prescribed a dose of 12 mg/kg/day ciprofloxacin, to be given by intravenous infusion in 2 divided doses. Which one of the following is the correct volume of ciprofloxacin infusion 2 mg/mL that should be given for each dose, rounded to the nearest mL? A B C D E 2 mL 4 mL 6 mL 12 mL 20 mL

Hydroxyzine hydrochloride syrup 10 mg/5 mL Initially 15 mg on for 1 week then 25 mg on for 1 week then 25 mg bd

5.

Which one of the following is the exact volume of hydroxyzine hydrochloride syrup 10 mg/5 mL that is required for a 28-day supply? A B C D E 210 mL 315 mL 420 mL 490 mL 630 mL

6.

Mr S who weighs 80 kg has been admitted to ITU following a coronary artery bypass graft. He is prescribed an intravenous infusion of dopamine 2.5 micrograms/kg/minute. The ITU routinely give dopamine as a 4 mg/mL solution. At what rate should the infusion be set for Mr S? A B C D E 3 mL/hour 4 mL/hour 6 mL/hour 8 mL/hour 9 mL/hour

7.

Indometacin (indomethacin) is used to close a patent ductus arteriosus in premature babies. Which one of the following is the correct initial dose of indometacin (indomethacin) for a 1-dayold baby weighing 750 g? A B C D E 0.015 mg 0.027 mg 0.057 mg 0.15 mg 1.5 mg

8.

Whilst working in the pharmacy aseptic unit you are asked to prepare 5 litres of a solution containing potassium ions 1 mmol/mL. What weight of potassium chloride is required? [atomic weight of potassium = 39; atomic weight of chlorine = 35.5] A B C D E 0.3725 g 0.745 g 37.25 g 74.5 g 372.5 g

9.

A patient with Parkinsons disease has been initiated on apomorphine injections. She is discharged from hospital with a supply of apomorphine 20 mg/2 mL ampoules and U100 insulin

1 mL syringes with needles. She requires a subcutaneous dose of 1.5 mg. When using her syringe how many units should she draw up each time? A B C D E 20 15 10 1.5 1

10.

A patient is admitted into hospital following a drug overdose. On admission a plasma concentration of 64 micrograms/mL is measured. Given that the half-life of the drug is 16 hours, what would you expect the approximate plasma concentration to be after 24 hours? (You may assume that the distribution is complete and the elimination is described by a 1st order process.) A B C D E 2 micrograms/mL 4 micrograms/mL 16 micrograms/mL 24 micrograms/mL 48 micrograms/mL

11.

A doctor decides to prescribe folic acid for a 3-month-old infant weighing 6 kg at a dose of 500 micrograms/kg/day. The folic acid syrup you have in stock contains 62.5 mg of folic acid per 125 mL. What volume of this syrup should be given daily?

A B C D E 12.

6.0 mL 3.0 mL 1.5 mL 0.6 mL 0.3 mL

You receive a prescription for 2.5% w/w sulphur in aqueous cream. What weight of sulphur do you need to make 75 g? A B C D E 3.33 g 2.5 g 2.25 g 1.88 g 1.5 g

13.

Mr P has a body surface area of 1.8 m2 and has been prescribed fludarabine by mouth at a dose of 40 mg/m2 daily for 5 days. You are asked to dispense a 5-day course of tablets for Mr P. The doctor has instructed you to round the daily dose to the nearest number of tablets. How many 10 mg tablets are required for the 5 day course? A 7

B C D E 14.

14 21 28 35

A manufacturer wishes to produce a batch of compressed tablets each containing 600 mg of active substance and with a mean tablet weight of 700 mg. What weight of active substance will be required for a total batch size of 420 kg? A B C D E 490 kg 400 kg 380 kg 360 kg 265 kg

15.

Mrs C is HIV positive and weighs 63 kg. She has been admitted to hospital for an elective caesarean section and is prescribed intravenous zidovudine to prevent maternal-foetal HIV transmission. She is prescribed zidovudine 2 mg/kg to be given over 1 hour in glucose 5% at a concentration of 2 mg/mL. Given that each ampoule of zidovudine contains 200 mg/20 mL, what volume of glucose 5% is required to prepare the infusion? A B C D E 12.6 mL 25.2 mL 50.4 mL 63 mL 239.4 mL

SECTION II (3 questions) Directions for questions 16 to 18. For each numbered question select the one lettered option above it which is most closely related to it. Within the group of questions each lettered option may be used once, more than once, or not at all. Questions 16 to 18 concern the following doses: A B C D E 50 mg three times a day 100 mg three times a day 100 mg four times a day 125 mg three times a day 125 mg four times a day

Select, from A to E, which one of the above: 16. is the minimum recommended dose of sulfasalazine (sulphasalazine) for maintenance of ulcerative colitis in a child aged 6 years, weighing 20 kg

17. 18.

is the maximum recommended dose of penicillamine for Wilsons Disease in a child aged 7 years, weighing 25 kg is the usual recommended dose of Fucidin suspension for a 6 month old baby weighing 7.5kg Directions Summarised A 1, 2, 3 B 1, 2 only C 2, 3 only D 1 only E 3 only

19.

A 2-year-old child weighing 13 kg is prescribed intramuscular pethidine hydrochloride to relieve acute pain. Which of the following fall within the recommended dosage range? 1 2 3 0.8 mL of a 10 mg/mL pethidine hydrochloride injection 0.3 mL of a 50 mg/mL pethidine hydrochloride injection 0.6 mL of a 50 mg/mL pethidine hydrochloride injection

20.

A woman with eclampsia has been prescribed an intravenous infusion of magnesium sulphate. Below is an extract from her prescription: magnesium sulphate 20% in 250 mL sodium chloride 0.9% 4 g magnesium sulphate to be given over 10 minutes, followed by 1 g every hour A nurse asks you to check her calculations. Which of the following is/are correct? 1 2 3 to give 4 g of magnesium sulphate over 10 minutes, the infusion rate should be set at 120 mL/hr to give 1 g of magnesium sulphate every hour the infusion rate should be set at 30 mL/hr the first 250 mL infusion bag should last for a maximum of 4 hours 30 minutes

An

elderly patient (500mg/5ml)

is

prescribed

Erythromycin

suspension

1 gram twice a day for 8 days. Each bottle consists of 100mls. How many whole bottles of syrup need to be dispensed?

A1
B C D E 1.6 2 2.4 4

2. A dermatologist prescribes 90g of 2.5% w/w salicylic acid in white soft paraffin. What is the weight of salicylic acid required for this preparation?

A 2.4mg
B C D E 2.6mg 2g 2.25g 4.25g

is the weight of Sodium Chloride in 350ml of Sodium Chloride infusion 0.9% w/v? A
B C D E 315mg 3.15g 3.75g 2.925g 0.63g

4. A medical practitioner prescribes 150g of 3.5% w/w sulphur in aqueous cream. The weight of aqueous cream required is:

A
B C D E

72.4g 144.75g 36.2g 5.25g 143g

5. A syringe driver is designed to contain 5ml of injection and a length of 60mm. Injection Y contains 4mg/ml. If a patient requires 2.5mg of drug Y per hour, at what rate setting in mm/hour should the syringe driver be fixed?

A
B C D E

3.75 7.5 12.0 6.0 7.2

6. The required dose of dopamine hydrochloride by intravenous infusion is 5mcg/kg/min. Dopamine intravenous solution contains 1.6mg per ml in 5% glucose in a 250ml bag. For a 64kg adult what volume per minute should the infusion be set at?

A
B C D E

5.0ml 0.5ml
2.5ml 2.0ml 0.2ml

7. A patient is admitted to hospital following an overdose of drug A. The drugs t1/2 (half life) is 8.5 hours. A toxic plasma concentration of 52 micrograms/ml is measured. How long in hours will it take for the plasma concentration to fall to 3.25 micrograms/ml?
You may assume that the absorption and destruction is complete and the elimination is described by a 1st order process.

A 24
B C D E 34 48 40 36

8. You are required to prepare 10 powders each weighing 300mg and containing 10mg of a drug. The only form of the drug that is available is a 30mg tablet. You will require: A Two tablets made up to 1.2g with lactose
B C D E Two tablets made up to 2.0g with lactose Three tablets made up to 3.0g with lactose Three tablets made up to 2.7g with lactose Four tablets made up to 3.6g with lactose

9. A potassium permanganate solution is to be diluted 10 times to a 0.01% solution. We have a stock solution of 16% potassium permanganate. How many ml of this stock solution need to be added to water to make 400ml of original solution to be diluted?

A
B C D E

25ml + 375ml water 2.5ml + 397.5ml water 0.4ml + 399.6ml water 4ml + 396ml water 5ml + 395ml water

10. What quantity of potassium chloride is required to prepare 2.5 litres of a solution containing 1mml per ml? Molecular weight = 74.5

A 372.5mg
B C D E 186.25g 745mg 18.625g 74.5g

11. You have been asked to prepare a solution from a commercially available concentrate, which contains 50% of a salt. Calculate how much of the concentrate you need to prepare 300ml of a 10% solution.

A 75ml
B C D E 60ml 30ml 200ml 20ml

12. A patient self-administers Human Mixtard 30 insulin using a 3ml disposable pen. He is prescribed a dose of 24 units in the morning and 18 units in the evening. How many syringes do you need to supply for 60 days treatment? A B C D 1 5 7 9

11

13. A doctor has prescribed 25g of an ointment containing 0.3% substance X, diluted with white soft paraffin. The only ointment available contains 1% of X. How much of this, in grams, do you need to weigh? A B C D E 6.25 7.5 10 12.5 33

14. A patient is prescribed Venlafaxine 75mg daily for 7 days, increasing by 75mg daily every week until a maximum daily dose of 375mg. A total of 6 weeks treatment must be dispensed. How many 75mg tablets do you dispense? A B C D E 147 105 115 140 175

15. Adrenaline injection 1 in 1000 in 0.5ml ampoules contains the following amount of adrenaline in milligrams per ampoule? A B C D E 0.5 1.0 5.0 1.5 0.05

16. What is the equivalent dose of Oromorph 10mg every 4 hours to Diamorphine HCI by SC infusion over 24 hours? A
B C D E 15mg 22mg 20mg 30mg 5mg

17. A 5-year-old child is prescribed Ventolin Syrup. The dose is 1mg Salbutamol tds. How many ml of Ventolin Syrup have to be dispensed to give the patient a four-week supply?

A
B C D E 8. Statement 1

280ml 210ml 140ml 105ml 420ml

500ml of 6.3% Calcium Chloride solution for parenteral use provides 428.4 mmol of Chloride-ions and 214.2mmol of Calcium-ions. Statement 2 2mg of Chloride-ions weigh more than 1 mg of Calcium-ions Decide whether:

A
B C D E

Statement 1 is true AND statement 2 is false Statement 1 is false AND statement 2 is false Statement 1 is false AND statement 2 is true Statement 1 is true AND statement 2 is true and Statement 2 explains Statement 1 Statement 1 is true AND statement 2 is true and Statement 2 does not explain statement 1

19. Which one of the following is the usual dose of oral theophylline for an 8-yearold child?

1
2 3

7.5ML Nuelin Liquid TDS 60mg Slo-Phyllin Capsules BD 62.5mg Nuelin Tablets TDS

20. The prescribed dose of dobutamine HCl by IV infusion is 5mcg/kg/min. One 20ml vial of Dobutrex is added to 1L of sodium chloride 0.9%. For a 50Kg adult the infusion rate, in ml per hour, should be set at?

A
B C D E

60 90
30 15 45

21. A renal transplant patient weighing 90Kg receives a loading IV dose of azathioprine of 5mg per Kg body weight. How many vials are required?

B C 6 D 9 E 12 22. A girl has been maintained on a dose of 200mg phenytoin at night for the last year. She is unable to swallow tablets. What volume in mls of phenytoin suspension 30mg in 5ml has equivalent activity? A B C D E 25 33.3 30 45 35

18 5

23. A male patient weighing 85Kg presents in A&E with a DVT. He is prescribed a 6 day course of s/c tinzaparin. How many 40,000units per 2ml vials would you supply? A B C D E 3 4 5 7 9

24. You have to make 350g of Coal Tar Paste B.P. What weight of Strong Coal Tar Solution in g do you need to weigh out? A B C D E 35 26.25 25 52.5 13.13

25. How much Hydrogen Peroxide 100 volume solution would you need to make 300ml of 6% solution? A B 30ml 60ml

C D E

90ml 18ml 36ml

26. patient is taking 2 Tylex capsules three times a day for pain and has a dry cough. How many 5ml doses of Codeine Linctus can he take, ensuring that he doesnt take more than the maximum daily dose of Codeine? A B C D E 2 3 4 5 6

27. A patient has been taking Calcium Gluconate 600mg tablets at a dose of 2 tablets three times a day. She is unable to swallow tablets and so you recommend a change to Calcium Sandoz syrup. What is the total daily dose of syrup in ml? A B C D E 10 15 20 25 30

A B C D E

25mg four times a day 30mg three times a day 100mg three times a day 100mg four times a day 125mg four times a day

28. Ibuprofen to treat pain in a child weighing 15Kg at a dose of 20mg/Kg per day.

Answer A B C D E
29. Paracetamol to treat pain in a jaundiced 8-week child weighing 5Kg.

Answer

30. Flucloxacillin to treat a staphylococcal infection in a 6-year-old child. Answer A B C D E

Basic Calculations What is 0.1mg written in kg? a. 0.0000001 b. 0.0001 c. 10 d. 100,000 e. 100 How much adrenaline is contained in a 10ml ampoule of adrenaline 1 in 10,000 injection? a. 1mg b. 1g c. 0.1mg d. 0.1g e. 10mg What is 0.001 litres written as mls? a. 0.000001 b. 0.0001 c. 1 d. 1,000 e. 1,000,000 How much adrenaline is contained in a 1ml ampoule of adrenaline 1 in 1,000 injection? a. 10mg b. 0.1g c. 0.1mg d. 1g e. 1mg A wholesaler offers you some atenolol 100mg tablets at a cost of only 40% of drug tariff (DT) price. The DT price is 49p/28 tablets. Your usual wholesaler provides these tablets at 80% of DT price. Your monthly usage of atenolol 100mg tablets is currently 50 calendar packs. How much will you save, over a 3-month period by purchasing your atenolol 100mg tablets from the new wholesaler, rather than your usual one? a. 784 b. 588 c. 392 d. 29.90 e. 9.80 % w/v type of calculations What volume of sodium bicarbonate is required to prepare 300mls of a stock solution containing sodium bicarbonate 5% w/v? a. 15mg b. 15g

c. 1.5g d. 150g e. 150mg What volume of 80% alcohol is required to prepare 3L of 20% alcohol? a. 50ml b. 500ml c. 600ml d. 750ml e. 850ml What is the concentration of dextrose in a solution prepared by mixing together 200mls of 10% w/v dextrose solution, 50mls of 20% w/v dextrose solution and 150mls of 5% w/v dextrose solution? a. b. c. d. e. 16.0%w/v 9.375%w/v 18.75%w/v 5.825%w/v 10.0%w/v

How many aspirin 300mg tablets does a patient dissolve in 120ml water if the aspirin concentration of the solution is 0.75%w/v? a. 1 b. 2.5 c. 2 d. 3.5 e. 3 How many millilitres of water must be added to 250ml of a 1.8% w/v stock solution to prepare a 0.09% w/v solution? a. 250ml b. 5000ml c. 4500ml d. 2500ml e. 4750ml Potassium permanganate calculations What quantity of ingredient is required to produce 500mls of a solution such that when 5mls of it is diluted to 50mls with water, it gives a 0.5% w/v solution? a. 25g b. 2.5g c. 250g d. 25mg e .2.5mg Potassium permanganate solution 1 in 8,000 is often prepared from a stock solution of 10 times this strength. How much potassium permanganate will be

needed to make sufficient stock solution if the patient uses 200mls of the diluted solution for 20 days? a. 50mg b. 100mg c. 125mg d. 250mg e. 500mg When used as a foot soak, potassium permanganate is usually prepared as a stock solution, which is then diluted down. You are asked to prepare 500mls of such a stock solution which, when 10mls is diluted to 5 litres, produces a final solution of 1 in 15,000. How much potassium permanganate is required? a. 13.3mg b. 16.7mg c. 13.3g d. 16.7g e. 30g You are required to prepare 400ml of a potassium permanganate stock solution, of which when 1 part is diluted with 7 parts a 1 in 4000 solution is made. How much potassium permanganate is needed to make the stock solution? a. 0.1g b. 0.2g c. 0.4g d. 0.8g e. 1.0g What weight of copper sulphate (in g or mg) is required to produce 150ml of a solution such that when 30ml of this solution is diluted to 150ml it produces a 1 in 5000 solution? a. 20mg b. 0.3g c. 30mg d. 300mg e. 0.15g

Extemp preparation calculations How much Eumovate cream is required to produce 350g of a 1:4 dilution of Eumovate cream in aqueous cream? a. b. c. d. e. 262.5g 280g 70g 87.5g 140g

How much dithranol is required to make the following prescription? 1.5% w/w dithranol in yellow soft paraffin Supply 450g To be applied as directed a. b. c. d. e. 6g 6.75mg 6.75g 67.5g 67.5mg

You receive a prescription for 120g fluticasone propionate cream 0.01%. How much Cutivate Cream do you need to weigh out? a. 2.4g b. 6g c. 12g d. 24g e. 42g Concentrated waters How much water is needed to make 300ml of double strength rosewater? (remember 1 part concentrated rosewater + 39 parts water = single strength water) a. 292.5ml b. 285ml c. 15ml d. 7.5ml e. 5ml What volume of chloroform water concentrate should you use to make 200ml of double strength chloroform water? a. 1.0ml b. 2.5ml c. 5.0ml d. 10.0ml e. 25.0ml

Half Life calculations A patient is admitted to hospital following an overdose of an antibiotic. The half-life of the drug is 6.5 hours. A toxic plasma concentration of 72mcg/ml is measured. How many hours will it take for the plasma concentration to fall to 2.25mcg/ml? You may assume that the absorption and distribution are complete and the elimination is described by a first order process. a. b. c. d. e. 26 32.5 32 104 19.5

A drug is being infused into a patient at 1mg/hr. Assuming 40% of the drug is excreted unchanged in the urine and plasma concentration is at steady state, how much of the unchanged drug is present in a cumulative 6 hour urine sample? a. b. c. d. e. 12mg 400mcg 2.4mg 4mg 1.2mg Syringe driver calculations / Rate A coated tablet has a dry weight of coating of 10mg/tablet. The coating solution is prepared to contain 10% w/v of coating material. How long is needed to coat a batch of 1 million tablets at a spray rate of 250mls/min, given that coating efficiency is 100%? a. b. c. d. e. 25 minutes 40 minutes 1 hour 40 minutes 4 hours 10 minutes 6 hours 40 minutes

A 60 year old male patient, weighing 80kg, is prescribed dopamine 4mcg/kg/min. A 0.16% w/v dopamine infusion is to be administered. What volume per minute should the infusion be set at? a. 0.5ml b. 5ml c. 12ml d. 2ml e. 0.2ml

Moles Whilst working in the pharmacy aseptic unit, you are asked to add 20 mmol of potassium ions to a batch of intravenous fluids. How many millilitres of potassium chloride injection 20% w/v do you need to add? (atomic weight of potassium = 39; atomic weight of chlorine = 35.5) a. b. c. d. e. 0.39mls 3.55mls 3.9mls 7.45mls 7.95mls

75mg of potassium chloride contains 1mmol of K+ and 1mmol of Cl ions. Given that Slow K tablets contain 600mg of potassium chloride, how many tablets should be dispensed for someone prescribed 40mmol K+ per day for 30 days? a. b. c. d. e. 400 300 250 150 30

A drug is given as a single dose each day of 300mcg/m2 body surface area. How much will a 6 month old child receive after a 5 day course if they have a body surface area of 0.4m2? a. 60mg b. 660mg c. 600mcg d. 6.6g e. 660mg Dosages Which one of the following contains approximately the same amount of elemental iron as one ferrous sulphate 200mg tablet three times a day? a. ferrous gluconate tablet 300mg four times a day b. Feospan two capsules daily c. Fersamal syrup 20ml twice daily d. Fersamal one tablet three times daily e. Sytron elixir 7.5ml three times a day What volume of cimetidine suspension should be dispensed for a one year old child of ideal weight, taking 30mg/kg daily for four weeks? a. 7.5mls b. 84mls c. 210mls d. 300mls e. 4200mls

Mrs Shah is taking Prednisolone 2.5mg tablets for an acute exacerbation of her asthma. She has been prescribed: 20mg od for 5 days then, 10mg od for 5 days then, reducing by 2.5mg each day till zero, then stop. How many tablets should you supply? 55 66 77 88

a. b. c. d. 99

Mr F brings in a prescription for his son, Jack, who is 6 years old. The prescription of for: pholcodine linctus 2mg/5ml, 5mls tds for 5 days. The pharmacy only has pholcodine linctus 5mg/5mls in stock. What volume of pholcodine linctus 5mg/5mls is required to prepare the correct quantity of the prescribed linctus? a. b. c. d. e. 30mls 15mls 10mls 6mls 3mls Morphine Questions 8 and 9 concern the following volumes of morphine sulphate injection 10mg/ml to be given by intramuscular or subcutaneous injection: A B C D E 0.12ml 0.18ml 0.24ml 1.8mls 2.4mls

Select from A to E which one of the above is the appropriate dose of morphine sulphate injection 10mg/ml for: 8. child aged 8 months, weighing 9kg, to treat acute pain Answer 9. B

child aged 3 years, weighing 16kg, as premedication C

Answer

1. How much anhydrous glucose is there in grams in 250ml of Glucose 5% intravenous infusion? A B C D E 7.5 12.5 10.5 25 2.5 2. Which one of the following is the amount of solid ingredient in grams in 750ml of a 1.5%w/v solution? A B C D E 15 112.5 11.25 7.5 75 3. What quantity of potassium chloride in grams is required to prepare 2 litres of a solution containing 2 mmol per ml? Molecular weight = 74.5 A B C D E 1490 59.6 14.9 149 298 4. A patient is prescribed Amoxicillin syrup 125mg in 5ml, with a dose of 75mg t.d.s. for 5 days. Which of the following volumes in mls would be the total volume dispensed? A B C D E 105 45 75 30 60 5. A man weighing 60Kg is prescribed dopamine 5mcg/Kg/min IV. The dopamine solution available for injection contains 4mg per ml. At what rate in ml/hour should the solution be set to run?

A B C D E

2.25 6 9 3 4.5 6. An antibiotic is available as vials containing 500mg powder, and 500mg of powder displaces 0.2ml. The vial is reconstituted with 1.8ml water for injection. A child is prescribed a dose of 200 mg. What volume in mls of antibiotic solution contains this amount?

A B C D E

0.8 1.6 0.4 0.6 1.2 7. What strength of potassium permanganate solution in %w/v should you prepare such that when 100ml is diluted to 10litres it gives a 1 in 8000 solution?

A B C D E

0.5 1.0 1.25 1.5 2.5 8. A patient is prescribed Venlafaxine 75mg daily for 7 days, increasing by 75mg daily every week until a maximum daily dose of 375mg. A total of 6 weeks treatment must be dispensed. How many 75mg tablets do you dispense?

A B C D E

147 105 115 140 175

9. Adrenaline injection 1 in 1000 in 0.5ml ampoules contains the following amount of adrenaline in milligrams per ampoule? A B C D E 0.5 1.0 5.0 1.5 0.05 10. A 10ml syringe driver is used to administer diamorphine HCl subcutaneously at 10 mg per hour. The driver causes 0.5ml of injection to be delivered per hour. How much diamorphine HCl powder in mg is needed to make 10ml of the injection solution? A B C D E 20 100 200 400 500 11.You are required to produce 30 powders each weighing 100mg and containing 5mg of drug. The drug is available as 15mg tablets. Which of the following would you require? A B C D E A B C D E 5 tablets made up to 30 gram with lactose 10 tablets made up to 3 gram with lactose 20 tablets made up to 4.5 gram with lactose 10 tablets made up to 6 gram with lactose 15 tablets made up to 3 gram with lactose 0.9 2.25 5.25 4.5 6.25
300ml of 1.75% w/v

12. 15 ml of 6% w/v 13. 250 ml of 2.5% w/v

14. 125 ml of 3.6% w/v

A patient weighing 50 Kg is admitted from A and E following an overdose of drug x. Drug xs half-life is 6 hours. On admission, the plasma concentration of x is found to be toxic at 36 micrograms per ml. How long in hours will it take to fall to the therapeutic level of less than 2.25 micrograms per ml, assuming elimination is a first order process?

A B C D E

12 24 18 30 15
15. You are required to dispense 400 mls of an aqueous solution of chlorhexidine which, when diluted 1 in 10, produces a 1 in 1000 solution. You have a concentrated 20% stock solution of chlorhexidine. How much concentrated solution in mls do you add to water to make the original solution for further dilution by the patient?

A B C D E

2 10 20 40 50

Open book What is the approximate maximum daily dose of the following medicines for a 3 year old child weighing 15Kg?

A B C D E

250mg t.d.s. 200mg q.d.s. 225mg bd 200mg 5 times a day 200mg t.d.s. 16. Oral ciprofloxacin for post-exposure prophylaxis to anthrax. 17. Amoxicillin for a severe infection.

18. Aciclovir for herpes simplex infection. 19. Paracetamol for pyrexia. 20. How many tablets of albendazole 400mg are needed for an initial course of treatment for strongyloides? C B C D E 3 12 112 56 6 21. How many mmol of Na+ are there in 500ml of Ringers solution for injection? A B C D E 65.5 73.5 14.7 78 2 22. A patient with manic depression is stabilised on Lithium Carbonate 1.0 grams daily. He is unable to swallow tablets after a jaw fracture. What volume of Priadel liquid in mls is equivalent? A B C D E 32.5 20 25 15 30 23.The same patient was also taking ferrous sulphate tablets, 200mg t.d.s.. What dose of Fersamal liquid would give a similar daily quantity of iron? A B 20 ml b.d. 15 ml o.d.

C D E 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 B C E B E A C D A C B C A E D B C C A D B E B C E

15 ml t.d.s. 15 ml b.d. 10 ml b.d.

1. A mother buys a 300ml bottle of cough linctus for her three children who are recovering from colds and gives the youngest 5ml tds, the middle one 7.5ml tds and the oldest 10ml tds. She does this for 4 days. How many doses for the youngest child are left in the bottle?

A6
B C D E 9 3 5 10

2. A proprietary brand of oral vitamin drops contain 5000 units per ml of vitamin A. The dropper provides 40 drops per ml. How many drops will provide a child with a dose of 750 units of vitamin A?

A3
B C D E 6 30 12 10

3. The concentration of fluoride in a sample of drinking water is 0.25ppm w/v. How many litres of water would contain 1mg of fluoride?

A2
B C D E 4 6 8 10

4. What weight in grams of malachite green oxalate is required to produce 500 ml of solution such that when 25ml of this solution is diluted to 4000 L, a 1 in 2,000,000 solution is prepared?

A4
B C D E 8 20 40 80

. How many milligrams of sodium fluoride are needed to make 250ml of a mouthwash containing 0.012mol/L of sodium fluoride? The molecular weight of sodium fluoride is 42.

A 50.4
B C D E 1260 504 63 126

6. Apomorphine injection is to be given via a syringe driver with a rate setting in mm/hour. The available injection contains 10mg in 1ml, and it is usual to dilute the injection with an equal volume of sodium chloride 0.9% before adding to the 10ml syringe. The 10ml syringe has a length of 60mm. The patient requires 7.5mg per hour. At what rate in mm/hour should the driver be set?

A 9.0
B C D E 4.5 6.0 18.0 12.0

7. Atenolol oral solution contains 25 mg of atenolol in 5.0ml. The European Pharmocopiea states that the atenolol content should be 94 to 104% of the stated amount. If a patient takes 5ml daily for 28 days, what is the difference between the prescribed amount of atenolol and the actual amount taken (in mg), if the atenolol content of the oral solution is at the lower limit?

A 56
B C D E 28 42 21 84

8. How many mls of concentrated chloroform water do you need to make 300ml of chloroform water?

A 15
B C D E 3.75 8 7.5 6

9. How many milligrams of aluminium acetate are required to prepare 500ml of a 0.03% w/v solution?

A 300
B C D E 30 15 125 150

10. A patient is prescribed dexamethasone daily for 8 weeks, starting at 8mg daily and decreasing by 1mg daily per week to a minimum maintenance dose of 5mg daily. Tablets are unscored and are available in 2 strengths, 2mg and

500micrograms. If you give both strengths of tablets to ensure that the patient has to swallow the least number of tablets possible, how many 500 microgram tablets will you supply?

A 56
B C D E 63 126 72 84

11. You have to dispense a prescription requiring: Glycerol White soft paraffin Ointment base to 10ml 25gram 100gram

The density of glycerol is 1.25g per ml. What weight of ointment base in grams is required to make up 60 grams of the final preparation?

A 31.5
B C D E 35 37.5 40 65

12. You need to give ciprofloxacin 200mg in 100ml intravenously over 30 minutes using a standard adult administration set (20 drops = 1ml). What drop rate (in drops per minute) is required?

A7
B C D E 34 67 133 267

13. You need to give a 500mg dose of streptomycin. You have a 1g vial of streptomycin powder which needs to be reconstituted. The injection powder has a displacement value 0.75ml per 1g. If you reconstitute the vial with 2.25ml, what volume in mls would you need to administer the dose of 500mg?

A 1.13
B C D E 1.5 1.3 3.0 1.0

14. A pharmacist has been asked to prepare three suspensions involving crushing tablets and making them up to volume with suspending vehicle. Which of the following is (are) correct formula(e)? 1 2 3 50 ml of chlorthiazide suspension 20 mg per ml: crush 2 x 500 mg tablets and make up to 50 ml with suspending base 300 ml of fenozime 5 mg in 5 ml: crush 30 x 10 mg tablets and make up to 300 ml with suspending base 50 ml of amiodarone suspension 100 mg in 5 ml: crush 10 x 200 mg tablets and make up to 50 ml with suspending base 1+2+3 1+2 1+3 2+3 3

A
B C D E

15. A patient requires 15mg of morphine sulphate by mouth every 4 hours for 15 doses. She has been prescribed a pack of Oramorph concentrated oral solution. What is the total volume in mls of morphine sulphate solution taken?

A 11.25
B C D E 1.65 22.5 9.5 9.75

16. A child weighing 7kg has an infection and microbiology has recommended that intravenous co-trimoxazole is given at the standard dose for 5 days. What volume in mls of intravenous infusion is required to be diluted for one dose?

A 0.66
B 2.63 C 1.53 D 1.31 E 0.94 17. What is the weight of liquid paraffin in 300 grams of Compound Benzoic Acid Ointment?

A 60
B C D E 54.6 18.2 40 53.9

18. Which one of the following contains approximately the same amount of elemental iron as one ferrous sulphate 200 mg tablet three times a day?

A
B C D E

Feospan, two capsules daily Ferrous gluconate tablets 300 mg four times a day Fersamel, one tablet three times a day Slow-Fe tablets, two daily Sytron Elixir 7.5 ml three times a day

19. How many drops of One-Alpha oral drops are equivalent to one brown One-Alpha capsule?

A
B C D E

1 5 10 15 20

20. An elderly lady has been prescribed Gaviscon liquid, 10 ml qds. You have been asked to calculate how many mmol of sodium ions she will receive each day from this. Which of the following is correct?

A 18.4
B C D E 20 24 30 40 Answers for Calcmar05 calculations 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 A B B D E A C D E E C C B B A D

17 18 19 20

B C C C

1.

What volume is 12.5mg of ranitidine injection contained in? It is supplied to you as 25mg/ml, 2ml vials A B C D E 0.75ml 0.6ml 1ml 0.25ml None of these

2.

What volume of codeine phosphate 25mg/5ml liquid would you need for a 30mg dose? A B C D E 5.1ml 5.5ml 6ml 6.6ml None of these

3.

How much digoxin elixir is required for a dose of 62.5 microgram? The supplied solution has a strength of 0.1mg/2ml. A B C D E 0.125ml 0.5ml 1ml 1.25ml None of these

4.

How many 0.0625mg digoxin tablets would you need for a 187.5 microgram dose?

A B C D E

30 3 15 12 Other

5.

What volume of low molecular weight heparin (supplied as 2ml vials of 20000 units/ml) would you need for an 11000 unit dose of tinzaparin ? A B C D E 0.45ml 0.5ml 0.55ml 1.1ml Other

6.

Which of the following drugs should not be given to a patient who is allergic to penicillin? (which row is correct) Magna Augmen Doxycycl Ciproflox Vancomy Tazoci Amikac tin ine acin cin n in OK Not OK OK OK OK Not OK OK Not OK Not OK Not OK Not OK Not OK Not OK OTHER OK OK OK Not OK OK OK OK Not OK OK OK OK Not OK OK Not OK OK

A B C D E

7.

An 84kg patient has been prescribed 175 units per kg of tinzaparin for a DVT. You have a 2ml multi-dose vial of tinzaparin 20000 units/ml. What volume would you administer? A B C D E 0.38ml 0.37ml 0.74ml 0.75ml Other

8.

You need to give a 500mg dose of streptomycin. You have a 1g vial of powder which needs to be reconstituted. The injection powder has a displacement value 0.75ml per 1g.

If you reconstitute the vial with 2.25ml, what volume would you need to administer the dose of 500mg? A B C D E 1.13ml 1.5ml 1.3ml 3ml Other

9.

You have a bottle of ciprofloxacin suspension labelled 250mg per 5ml. What volume would you need to measure to give a 750mg dose? A B C D E 3ml 15ml 7.5ml 30ml Other

10. You need to give ciprofloxacin 200mg in 100ml intravenously over 30

minutes using a standard adult administration set (20 drops = 1ml). What drop rate (in drops per minute) is required? A B C D E 7 drops per minute 34 drops per minute 67 drops per minute 133 drops per minute Other

11. A patient has just been prescribed the cytotoxic drug cyclophosphamide
75mg daily orally. You only have a supply of 50mg tablets on the ward and the Pharmacy Department is now closed. What would you do?

A B C D E

Contact the on-call pharmacist for advice Give 50mg and discuss it with the doctor Use a tablet cutter and give one-and-a-half tablets Disperse 2 tablets in water and give of the volume Give 100mg and review

12. A heparin infusion 30000 units in 30ml is boarded with directions to

infuse it at a rate of 27000 units over 24 hours in response to the patients APTT result. What rate should be syringe driver be set at? A B C D E 0.89ml/hour 1ml/hour 1.125ml/hour 1.3ml/hour Other

Calculations test October 2003 You have 60 minutes to complete 20 calculations. Use the BNF for the open book questions, if appropriate. Closed book 1. How many grams of sodium chloride are there in a 250ml infusion of sodium chloride 1.8%? A B C D E 1.8 4.5 18 2.7 9

2. What quantity of potassium chloride is required to prepare 2 litres of a solution containing 1 mmol/ml? Molecular weight = 74.5 A B C D 74.5 37.25 149 372.5

14.9

3. A 55 year old patient weighing 80 kg has been admitted to CCU and is prescribed dopamine 2.5 micrograms/kg/min intravenously. What is the rate (in ml/hour) at which the solution of dopamine must be infused using a 4mg/ml injection solution? A B C D E 12 4 3 0.8 0.3

4. A concentrated solution of sodium chloride contains 25% w/v of the active ingredient in water. What volume of the concentrate (in ml) would you need to prepare 300ml of sodium chloride 10% w/v diluted solution? A B C D E 75 60 30 120 50

5. Mrs Khatun is HIV positive and has been admitted for elective caesarean section. She weighs 63 kg and is 27 years old. During labour, zidovudine has been prescribed intravenously at 2mg/kg body weight over 60 minutes. What volume (in mls) of sodium chloride 0.9% is necessary to produce the exact volume of a 2 mg/ml zidovudine infusion for her? Zidovudine is available as 200 mg in 20 ml ampoules. A B C D E 12.6 25.2 50.4 63 239.4

6. Salbutamol tablets BP are available as tablets containing salbutamol sulphate equivalent to 2 mg and 4 mg of salbutamol. To prepare

salbutamol 2 mg tablets, what weight of salbutamol sulphate in mg is needed in each tablet? Molecular weights are Salbutamol 239.3 Salbutamol sulphate 576.7 A B C D E 0.83 1.66 2.00 2.41 4.82

7. You receive a prescription for captopril 3.125 mg qds for 30 days. The lowest strength preparation of captopril available to you is 12.5 mg tablets, each weighing 75 mg, so after discussion with the prescriber you decide to supply 200 mg powders each containing 3.125 mg of captopril using lactose as a diluent. What weight of lactose in grams needs to be added to the tablets to supply the exact amount required on the prescription? A B C D E 3.75 21.75 22.8 23.625 24.75 8. A child weighing 15 kg has been admitted for surgery. During the operation he is given an intravenous dose of 4 micrograms/kg fentanyl injection. The fentanyl injection contains 100 micrograms/2ml. What volume of fentanyl injection (in mls) should he be given? A B C D E 0.6 1.2 3.0 6.0 12.0

9. Calculate the quantity of suppository base (in g) required to make 120 suppositories each containing 10 mg of morphine hydrochloride. The capacity of the mould is 1 g and the displacement value for morphine is 1.6. Formula:
Quantity of base = (Number of suppositories x Capacity of mould [g]) Total quantity of medicament [g] Displacement Value

A B C D E

90.0 112.5 119.25 120.75 122.5 These next 2 questions are followed by 3 answers. For each question, one or more of the responses is correct. Decide which of the responses is (are) correct, then choose If 1, 2, and 3 are correct If 1 and 2 only are correct If 2 and 3 only are correct If 1 only is correct If 3 only is correct

A B C D E

10. Which of the following will provide a 0.3mg dose of adrenaline/epinephrine? 1. 3 ml of a 100 microgram/ml solution 2. 0.3 ml of a 1 in 1000 solution 3. 0.03 ml of a 1 in 10,000 solution Tick box A B C D E 11. A prescription for a child requires you to dispense 30 ml of thyroxine suspension 50 micrograms in 5 ml. The dose is 37.5 micrograms once a day. The formula is: Thyroxine tablets 100 micrograms q.s. (sufficient number) Compound Tragacanth powder 1 gram Syrup B.P. 10 ml Concentrated Chloroform Water B.P.C. 1.25 ml

Purified water to 50 ml Which of the following statements is true? 1. To dispense the quantity prescribed, 3 x 100 microgram thyroxine tablets should be used 2. The child should be given 3.75 ml each day 3. To dispense the quantity prescribed, the formula should contain 1 ml of Concentrated Chloroform Water. Tick box A B C D E Open book Each group of questions below consists of 5 lettered options followed by a list of numbered questions. For each numbered question select and tick the one lettered option that is most closely related to it. Each lettered option may be used once, more than once, or not at all. Questions 12 to 16 concern the following doses A B C D E 50 mg four times a day 60 mg three times a day 100 mg three times a day 100 mg four times a day 125 mg four times a day

12. Which is the maximum recommended oral dose of ibuprofen for juvenile arthritis in a child aged 1 year, weighing 10 kg? Tick box A B C D E

13. Which is the recommended minimum parenteral dose of clindamycin for a severe infection in a 2 year old child weighing 13.3 kg? Tick box A B C D E 14.What is the maximum recommended intramuscular dose of cefuroxime for a 1 week-old baby weighing 3 kg? Tick box A B C D E 15.What is the recommended dose of nalidixic acid for the prolonged treatment of a urinary tract infection in a 16 kg child? Tick box A B C D E 16.What is the slow intravenous injection dose of hydrocortisone (as sodium succinate) for a 4-year old child? A B C D E 17.An elderly lady has been prescribed Gaviscon liquid, 10 ml qds. You have been asked to calculate how many mmol of sodium ions

she will receive each day from this. Which of the following is correct? A B C D E 18.4 20 24 30 40
18. A 55 year old lady has a body surface area of 1.60m. She has been

diagnosed with primary ovarian cancer, and has been prescribed Taxol 175mg/m. When making up the Taxol intravenous infusion, what volume of Taxol Concentrate (in mls) should you use? A B C D E 4.67 5.25 32.5 46.7 52.5

19. What weight of light magnesium carbonate (in grams) is needed to make 250 ml of Aromatic Magnesium Carbonate Mixture B.P.? A B C D E 3.5 4.5 5.5 6.5 7.5

20. This question consists of a statement in the left hand column followed by a second statement in the right hand column. Decide whether the first statement is true or false. Decide whether the second statement is true or false. Then choose Directions Summarised
First Second Statement Statement

A B C D

True True True False

True True False True

2nd statement is a correct explanation of the first 2nd statement is NOT a correct explanation of the first

False

False

You have received a telephone call from a junior doctor in the hospitals Accident and Emergency department. He is treating a patient with ventricular arrhythmias following myocardial infarction, and has already given him 100mg lidocaine (lignocaine) as a bolus dose. He now wants to start an infusion of lidocaine using a standard 0.2% infusion, and asks you to advise on the infusion rate. First statement Second statement The infusion rate should be set The initial rate of lidocaine for the at 120ml/hour for the first 30 treatment of ventricular arrhythmias is minutes 4mg/minute for the first 30 minutes Question Answer 1 B 2 C 3 C 4 D 5 C 6 E 7 B 8 B 9 C 10 B 11 B 12 D 13 C 14 C 15 E 16 A 17 C 18 D 19 E 20 A