Scribd
Upload
36 views16 pages

Pharmacokinetics: Two-Compartemet Model

This document discusses a two-compartment pharmacokinetic model. The model consists of a central compartment and a peripheral compartment connected by distribution rate constants k12 and k21. Drug is administered into the central compartment and is eliminated from there at a rate of k13. The concentrations of drug in each compartment over time can be described using exponential decay equations involving the rate constants. Parameters like elimination half-life, volume of distribution, clearance, and area under the curve can be calculated based on the concentration-time profile and dosing information.

Uploaded by

marinasirait
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
36 views16 pages

Pharmacokinetics: Two-Compartemet Model

This document discusses a two-compartment pharmacokinetic model. The model consists of a central compartment and a peripheral compartment connected by distribution rate constants k12 and k21. Drug is administered into the central compartment and is eliminated from there at a rate of k13. The concentrations of drug in each compartment over time can be described using exponential decay equations involving the rate constants. Parameters like elimination half-life, volume of distribution, clearance, and area under the curve can be calculated based on the concentration-time profile and dosing information.

Uploaded by

marinasirait
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PPT, PDF, TXT or read online on Scribd
You are on page 1/ 16

Pharmacokinetics

Two-compartemet Model

Ahmad Muhtadi
FACULTY OF PHARMACY
UNIVERSITAS PADJADJARAN
Two-compartemen
( intravascular)

Characteristics :

No absorption
All injected drug is in the systemic circulation
Slow distribution of drugs between blood stream and tissue
Equalibrium (stady state) is obatain some later time after
administration
Steep fall of first part of blood level curve due to distribution
Decline of second part of blood level curve depends on back
distribution of drug from tissue to the blood, exretion and
metabolism.
Two-compartemen
( intravascular)

Model :

PC

k12 k21 D = dose adminestered


CC = central compartment
k13 PC = peripheral compartment
D CC k12,k21= distributian rate constants
Vc k13 = eilimination rate constant
from central compartment
C Vc = volume of central compartment
C = drug concentration in central
compartment
Determination of the postdistribution rate constant
(β) and the coefficient (α)

Cp = B.e-βt + A.e-αt [μg/mL]

Cp = D . [ (k21 - β ). e-βt - (k21 – α). e-αt ]


[Ve. (α – β)]
Log Consentration

Cpo
C1’ C1 diff
A
C2 diff
B C2’
C1
C2
C1
C2
β
α

t1’ t2’ t1 t2
Time
Rate Constanta :

β = ( ln C1 – ln C2 ) hour -1
( t2 - t 1 )

α = ( ln C1 diff – ln C2 diff ) hour -1


( t2 - t1 )
k12 = [A. B (β – α ) 2 ] hour -1
[ Cpo (A.β + B.α) ]

k 21 = (A . β + B . α ) hour -1
( Cpo )
K 13 = ( Cpo )
( A + B)
hour -1
α β
Cpo = A + B ( μg/ mL)

A= ( α – k 21 ) ( μg/ mL)
(α–β)

B= ( k 21 – β) ( μg/ mL)
(α–β)

α + β = k12 + k21 + k13

α . β = k21 . k13
Half life :

t½ α = 0,693 hour
α

t½ β = 0,693 hour
β
Volume Distribution :

Ve = D ( mL )
Cpo

Vd ss = Ve + Vt ( mL )

Vd ss = ( k 12 + k 21 ) . Ve ( mL )
k 21
Volume Distribution :
B = D. ( k21 – β ) ( mL )
Ve . ( α – β )

Vd ekstrapolasi = D = Ve. ( α – β ) ( mL )
B ( k21 – β )

Vd area = Vd ss + k13 – β . Ve ( mL )
k21– β
AREA UNDER CURVE (AUC)
Cp = B.e-βt + A.e-αt
Cp.dt = B.e-βt + A.e-αt
[ AUC ] = B + A
β α
[AUC] = ( B . β+ A . α )
(β.α)
[AUC] = ( B + A )
k13
[AUC] = D
( k13 . Ve )
Clirens :

Cl = D
[ AUC ]
BIOAVAIILABILITY (F) :

F absolut : { [AUC] po }
{ [AUC] iv }

F relatif : { [AUC] po }
{ [AUC] po* }

* = drug standard
Problem :

100 mg drug given by iv injection to patien

Calculaton abaut all pharmacokinetics parameters

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy