Scribd
Upload
130 views2 pages

Information About Glimepiride

Glimepiride is a sulfonylurea drug used to treat type 2 diabetes by stimulating the pancreas to release more insulin. It is taken orally once per day with a meal. Glimepiride is generally well-absorbed, highly protein-bound, and metabolized in the liver before being excreted in urine. The drug increases insulin production and sensitivity to help control blood sugar levels while having a lower risk of hypoglycemia than other sulfonylureas like glyburide. Common side effects include gastrointestinal issues and potential allergic reactions.

Uploaded by

meimeiliu
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
130 views2 pages

Information About Glimepiride

Glimepiride is a sulfonylurea drug used to treat type 2 diabetes by stimulating the pancreas to release more insulin. It is taken orally once per day with a meal. Glimepiride is generally well-absorbed, highly protein-bound, and metabolized in the liver before being excreted in urine. The drug increases insulin production and sensitivity to help control blood sugar levels while having a lower risk of hypoglycemia than other sulfonylureas like glyburide. Common side effects include gastrointestinal issues and potential allergic reactions.

Uploaded by

meimeiliu
Copyright
© Attribution Non-Commercial (BY-NC)
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 2

More information: http://www.guidechem.com/cas-934/93479-97-1.

html

Information about Glimepiride


Glimepiride is a medium- to long-acting sulfonylurea antidiabetic drug.Glimepiride is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes (non-insulin-dependent diabetes). It may also be used with other diabetes medications. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Glimepiride belongs to the class of drugs known as sulfonylureas. It lowers blood sugar by causing the release of your body's natural insulin. 1. Indication / contraindications

Glimepiride is indicated to treat type 2 diabetes mellitus; its mode of action is to increase insulin production by the pancreas. It is not used for type 1 diabetes because in type 1 diabetes the pancreas is not able to produce insulin. Its use is contraindicated in patients with hypersensitivity to glimepiride or other sulfonylureas, and during pregnancy. 2. How to use it? Glimepiride comes as a tablet to take by mouth. It is usually taken once a day with breakfast or the first main meal of the day. To help you remember to take glimepiride, take it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take glimepiride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Your doctor will probably start you on a low dose of glimepiride and gradually increase your dose if needed. After you have taken glimepiride for some time, glimepiride may not control your blood sugar as well as it did at the beginning of your treatment. Your doctor may adjust the dose of your medication as needed so that the medication will work best for you. Be sure to tell your doctor how you are feeling and if your blood sugar test results have been higher or lower than normal at any time during your treatment. Glimepiride helps control blood sugar but does not cure diabetes. Continue to take glimepiride even if you feel well. Do not stop taking glimepiride without talking to your doctor.

3. Pharmacokinetics

More information: http://www.guidechem.com/cas-934/93479-97-1.html

Gastrointestinal absorption is complete, with no interference from meals. Significant absorption can occur within one hour, and distribution is throughout the body, 99.5% bound to plasma protein. Metabolism is by oxidative biotransformation. Excretion in the urine is 65%, and the remainder is excreted in the feces. 4. Mechanism of action Like all sulfonylureas, glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors. Not all secondary sufonylureas have the same risks of hypoglycemia. Glibenclamide (glyburide) is associated with an incidence of hypoglycemia of up to 2030%, compared to as low as 2% to 4% with glimepiride. Glibenclamide also interferes with the normal homeostatic suppression of insulin secretion in reaction to hypoglycemia, whereas glimepiride does not. Also, glibenclamide diminishes glucagon secretion in reaction to hypoglycemia, whereas glimepiride does not. 5. Adverse effects Side effects from taking glimepiride include gastrointestinal tract (GI) disturbances, occasional allergic reactions, and rarely blood production disorders including thrombocytopenia, leukopenia, and hemolytic anemia. In the initial weeks of treatment, the risk of hypoglycemia may be increased. Alcohol consumption and exposure to sunlight should be restricted because they can worsen side effects. 6. Missed dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. 7. Storage Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy