0% found this document useful (0 votes)
974 views1 page

Drug Therapy Requiring Intensive Monitoring For Toxicity

This document discusses drug therapy that requires intensive monitoring for toxicity. It lists several categories of drugs, such as cardiac drugs, antibiotics, antiepileptics, and immunosuppressants, that have a narrow therapeutic window and may cause toxicity if levels are not closely monitored. The document provides the table of drugs in each category and their typical treatment uses. It states that intensive monitoring of drug levels is necessary for drugs with a low therapeutic index to avoid toxicity occurring near the upper limit of the therapeutic range.

Uploaded by

adllurikaushik
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
0% found this document useful (0 votes)
974 views1 page

Drug Therapy Requiring Intensive Monitoring For Toxicity

This document discusses drug therapy that requires intensive monitoring for toxicity. It lists several categories of drugs, such as cardiac drugs, antibiotics, antiepileptics, and immunosuppressants, that have a narrow therapeutic window and may cause toxicity if levels are not closely monitored. The document provides the table of drugs in each category and their typical treatment uses. It states that intensive monitoring of drug levels is necessary for drugs with a low therapeutic index to avoid toxicity occurring near the upper limit of the therapeutic range.

Uploaded by

adllurikaushik
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
You are on page 1/ 1

Management Options: Drug Therapy Requiring Intensive Monitoring for Toxicity

The Table of Risk lists drug therapy requiring intensive monitoring for toxicity as a high risk management
option.
For drugs with a well-defined clinical response and a high therapeutic index (i.e., low toxicity), intensive
therapeutic drug monitoring is not necessary. For acute or short-term drug therapy there is no advantage to
monitoring drug levels. For treatment of chronic disorders, such as antihypertensive therapy, if the desired
response can be readily assessed by a noninvasive technique, such as blood pressure monitoring, serial drug
level monitoring is not medically necessary.
Administration of cytotoxic chemotherapy is always considered high risk under management options when
monitoring of blood cell counts is used as a surrogate for toxicity.
Drugs that have a narrow therapeutic window and a low therapeutic index may exhibit toxicity at
concentrations close to the upper limit of the therapeutic range and may require intensive clinical
monitoring. The table below lists examples of drugs that may need to have drug levels monitored for
toxicity. This is not an all exclusive list. On medical review, to consider therapy with one of these drugs as
a high risk management option, we would expect to see documentation in the medical record of drug levels
obtained at appropriate intervals.
Table of Risk
Drug Category Drugs in that Category Treatment Use
Cardiac drugs Digoxin, digitoxin, quinidine,
procainamide, amiodarone
Congestive heart failure, angina,
arrhythmias
Antibiotics Aminoglycosides (gentamicin,
tobramycin, amikacin) Vancomycin,
Chloramphenicol
Infections with bacteria that are
resistant to less toxic antibiotics
Antiepileptics Phenobarbital, phenytoin, valproic
acid, carbamazepine, ethosuximide,
sometimes gabapentin, lamotrigine
Epilepsy, prevention of seizures,
sometimes to stabilize moods
Bronchodilators Theophylline, caffeine Asthma, Chronic obstructive
pulmonary disorder (COPD),
neonatal apnea
Immunosuppressants Cyclosporine, tacrolimus, sirolimus,
mycophenolate mofetil, azathioprine
Prevent rejection of transplanted
organs, autoimmune disorders
Anti-cancer drugs All cytotoxic agents Multiple malignancies
Psychiatric drugs Lithium, valproic acid, some
antidepressants (imipramine,
amitriptyline, nortriptyline, doxepin,
desipramine)
Bipolar disorder (manic depression),
depression
Protease inhibitors Indinavir, ritonavir, lopinavir,
saquinavir, atazanavir, nelfinavir
HIV/AIDS
Instructions to locate Article:
Palmetto GBA Browse by Topic, located under E/M Help Center
o Ohio: http://www.PalmettoGBA.com/boh
o West Virginia: http://www.PalmettoGBA.com/bwv
o South Carolina: http://www.PalmettoGBA.com/bsc
Palmetto GBA
Medicare Part B OH/WV/SC
July 2009

You might also like

pFad - Phonifier reborn

Pfad - The Proxy pFad of © 2024 Garber Painting. All rights reserved.

Note: This service is not intended for secure transactions such as banking, social media, email, or purchasing. Use at your own risk. We assume no liability whatsoever for broken pages.


Alternative Proxies:

Alternative Proxy

pFad Proxy

pFad v3 Proxy

pFad v4 Proxy