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AMINES

This document discusses several named reactions involving amines: 1) Ammonolysis is the reaction of an alkyl or benzyl halide with ethanolic ammonia, replacing the halogen with an amino group. 2) Gabriel phthalimide synthesis uses phthalimide to prepare primary amines from alkyl halides. 3) The carbylamine reaction forms isocyanides when primary amines are heated with chloroform and ethanolic potassium hydroxide.

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223 views4 pages

AMINES

This document discusses several named reactions involving amines: 1) Ammonolysis is the reaction of an alkyl or benzyl halide with ethanolic ammonia, replacing the halogen with an amino group. 2) Gabriel phthalimide synthesis uses phthalimide to prepare primary amines from alkyl halides. 3) The carbylamine reaction forms isocyanides when primary amines are heated with chloroform and ethanolic potassium hydroxide.

Uploaded by

muhammad
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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NAMED REACTION

AMINES
an alkyl or benzyl halide on reaction with an ethanolic solution of
ammonia undergoes nucleophilic substitution reaction in which the
halogen atom is replaced by an amino (NH2 ) group. This process of
cleavage of the CX bond by ammonia molecule is known as ammonolysis

5. Gabriel phthalimide synthesis is used for the preparation of primary


amines. Phthalimide on treatment with ethanolic potassium hydroxide
forms potassium salt of phthalimide which on heating with alkyl halide
followed by alkaline hydrolysis produces the corresponding primary
amine.

Carbylamine reaction Aliphatic and aromatic primary amines on heating


with chloroform and ethanolic potassium hydroxide form isocyanides or
carbylamines which are foul smelling substances. Secondary and tertiary
amines do not show this reaction. This reaction is known as carbylamine
reaction or isocyanide test and is used as a test for primary amines.

NAMED REACTION
AMINES

Benzenesulphonyl chloride (C6H5SO2Cl), which is also known as


Hinsbergs reagent, reacts with primary and secondary amines to form
sulphonamides.
(a)The reaction of benzenesulphonyl chloride with primary amine yields Nethylbenzenesulphonylamide.

The hydrogen
attached to
nitrogen in
sulphonamide is
strongly acidic due to the presence of strong electron withdrawing
sulphonyl group. Hence, it is soluble in alkali.
(b) In the reaction with secondary amine, N,Ndiethylbenzenesulphonamide is formed.

Since N, N-diethylbenzene sulphonamide does not contain any hydrogen


atom attached to nitrogen atom, it is not acidic and hence insoluble in
alkali.
(b)Tertiary amines do not react with benzenesulphonyl chloride. This
property of amines reacting with benzenesulphonyl chloride in a
different manner is used for the distinction of primary, secondary and
tertiary amines and also for the separation of a mixture of amines.
However, these days benzenesulphonyl chloride is replaced by ptoluenesulphonyl chloride.
Benzenediazonium chloride is prepared by the reaction of aniline with
nitrous acid at 273-278K. Nitrous acid is produced in the reaction
mixture by the reaction of sodium nitrite with hydrochloric acid. The

NAMED REACTION
AMINES
conversion of primary aromatic amines into diazonium salts is known
as diazotisation.

chlorine or bromine can also be introduced in the benzene ring by


treating the diazonium salt solution with corresponding halogen acid in
the presence of copper powder. This is referred as Gatterman reaction.

NAMED REACTION
AMINES

They are able to form H-bonds with waters, hence missible

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