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Poikilocytosis Review Table

This document describes different types of abnormal red blood cells (poikilocytosis) including their appearance under the microscope and associated diseases. Teardrop cells are pointed at one end and seen in myelofibrosis. Spherocytes are smaller and round, associated with hereditary spherocytosis and burns. Target cells have a bullseye appearance and are seen in sickle cell disease. Sickle cells are crescent or thorn shaped in sickle cell anemia. Stomatocytes are cup shaped with a central pallor and linked to alcoholism and liver disease. Schistocytes are fragmented red blood cells seen after trauma, HUS, and DIC.

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709 views5 pages

Poikilocytosis Review Table

This document describes different types of abnormal red blood cells (poikilocytosis) including their appearance under the microscope and associated diseases. Teardrop cells are pointed at one end and seen in myelofibrosis. Spherocytes are smaller and round, associated with hereditary spherocytosis and burns. Target cells have a bullseye appearance and are seen in sickle cell disease. Sickle cells are crescent or thorn shaped in sickle cell anemia. Stomatocytes are cup shaped with a central pallor and linked to alcoholism and liver disease. Schistocytes are fragmented red blood cells seen after trauma, HUS, and DIC.

Uploaded by

kat
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Poikilocytosis Review Table

Cell Type Image Cellular Description Associated Diseases and Conditions

Teardrop cell Red blood cells (RBCs) are Myelofibrosis with myeloid
shaped like a teardrop with a metaplasia (MMM)
projection extending from one
end.

Spherocyte RBCs smaller than normal Hereditary spherocytosis


No central pallor Certain hemolytic anemias
Round rather than disc-shaped (eg, autoimmune hemolytic
anemia)
Severe burns
Target cell RBCs with characteristic bull's- Hemoglobinopathies (e.g.,
eye morphology due to sickle cell disease)
hemoglobin distribution Certain thalassemias
Iron deficiency anemia
Splenectomy
Severe liver disease

Sickle cell RBCs contain hemoglobin S. Sickle cell anemia


Thorn or crescent-shaped
Stomatocyte RBCs with thin, elongated area Hereditary stomatocytosis
of central pallor (slit-like, or Alcohol-related disease
coffee-bean-shaped on Liver disease
peripheral blood smears) Rh null phenotype
Three-dimensionally, RBCs are Artifact
cup-shaped.

Schistocyte RBC blood cell fragments or Severe burns


(fragmented red pieces Hemolytic uremic syndrome
cells) Vary widely in size and shape (HUS)
Microangiopathic hemolytic
anemia (MAHA)
Disseminated intravascular
coagulation (DIC)
Thrombotic
thrombocytopenic purpura
(TTP)
Ovalocyte RBCs are elongated-oval, cigar, Hereditary elliptocytosis
(elliptocyte) or pencil-shaped. Megaloblastic anemia
Myelophthisic anemia
Certain thalassemias
Severe iron deficiency

Acanthocyte RBCs demonstrating irregularly- Abetalipoproteinemia


(Spur cell) spaced, spiny projections that Severe hepatic disease
vary in size and number Myeloproliferative disorders
No central pallor MAHA
. Neuroacanthocytosis
syndromes
Echinocyte (Burr RBCs have short and evenly- Uremia
cell) spaced, rounded projections Heart disease
surrounding the cell. Pyruvate kinase deficiency
Central pallor present Stomach cancers
Bleeding peptic ulcers

Bite cell Red cells that appear to have Disorders associated with Heinz
bites taken out of them (Image body formation:
A) Unstable hemoglobins
Supravital stain reveals the Chemical poisoning
presence of Heinz bodies-- G-6PD
precipitated denatured masses Hemolytic anemia associated
of hemoglobin (Image B). with severe alcoholic liver
disease

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